Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia
In this study, we describe the kinetics of a new potential inflammatory biomarker, presepsin, together with a panel of well-established biomarkers in a human endotoxemia study. We evaluated biomarker correlations and identified combinations that could hold valuable insights regarding the state of infection. (Source: Inflammation Research)
Source: Inflammation Research - July 21, 2022 Category: Research Source Type: research
Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis
ConclusionsWe proved that knockdown of H19 alleviated ox-LDL-induced HCAECs injury via miR-20a-5p/HDAC4 axis, which might provide a new tactics against CAD. (Source: Inflammation Research)
Source: Inflammation Research - July 19, 2022 Category: Research Source Type: research
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(Source: Inflammation Research)
Source: Inflammation Research - July 19, 2022 Category: Research Source Type: research
IL-25 directly modulates adipocyte function and inflammation through the regulation of adiponectin
ConclusionOur studies suggest that IL-25 directly regulates adipocyte function by maintaining the adiponectin level during homeostasis and by alleviating inflammatory response through the regulation of adiponectin during low-grade inflammation in adipocytes. (Source: Inflammation Research)
Source: Inflammation Research - July 12, 2022 Category: Research Source Type: research
Heme oxygenase-1 protects against endotoxin-induced acute lung injury depends on NAD+-mediated mitonuclear communication through PGC1 α/PPARγ signaling pathway
In this study, we observed HO-1 attenuated endotoxin-induced ALI by regulated NAD+ levels and NAD+ affected the mitonuclear communication, including mitonuclear protein imbalance and UPRmt to alleviate lung damage. We also found the protective effect of HO-1 depended on NAD+ and NAD+-mediated mitonuclear communication. Furtherly, the inhibition of the PGC1 α/PPARγ signaling exacerbates the septic lung injury by reducing NAD+ levels and repressing the mitonuclear protein imbalance and UPRmt. Altogether, our study certified that HO-1 ameliorated endotoxin-induced acute lung injury by regulating NAD+ and NAD+-mediated miton...
Source: Inflammation Research - July 11, 2022 Category: Research Source Type: research
The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence
ConclusionOverall, our findings revealed the immunomodulatory potential of naringenin as an alternative treatment on inhibition of inflammation and OS in several autoimmune-related diseases. Nevertheless, regarding the limitation of clinical trials, strong preclinical models and clinical settings in the future are needed that address the effects of naringenin on ADs. Before large-scale clinical studies, precise human pharmacokinetic investigations are required to determine the dosage ranges and evaluate the initial safety profile of naringenin. (Source: Inflammation Research)
Source: Inflammation Research - July 8, 2022 Category: Research Source Type: research
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination
ConclusionCaffeine mitigated the acute liver injury by stimulating NEDD4L expression, which inhibited GRP78 expression via ubiquitination at its K324 site. Low dose of caffeine could be a promising therapeutic treatment for acute liver injury. (Source: Inflammation Research)
Source: Inflammation Research - July 8, 2022 Category: Research Source Type: research
The role of Th17 cells: explanation of relationship between periodontitis and COPD?
AbstractPeriodontitis and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases with common risk factors, such as long-term smoking, age, and social deprivation. Many observational studies have shown that periodontitis and COPD are correlated. Moreover, they share a common pathophysiological process involving local accumulation of inflammatory cells and cytokines and damage of soft tissues. The T helper 17 (Th17) cells and the related cytokines, interleukin (IL)-17, IL-22, IL-1 β, IL-6, IL-23, and transforming growth factor (TGF)-β, play a crucial regulatory role during the pathophysiological pro...
Source: Inflammation Research - July 4, 2022 Category: Research Source Type: research
MAIT cells and their implication in human oral diseases
ConclusionCollected evidence elucidated the characteristics of MAIT cells and emphasized the potential roles of MAIT cells in oral lichen planus (OLP), chronic graft-versus-host disease (cGVHD), oral squamous cell carcinoma (OSCC), apical periodontitis (AP) and primary Sjogren's syndrome (pSS). (Source: Inflammation Research)
Source: Inflammation Research - July 4, 2022 Category: Research Source Type: research
IL-38, a potential therapeutic agent for lupus, inhibits lupus progression
ConclusionIL-38 regulates SLE pathogenesis. Furthermore, targeting IL-38 is critical in the treatment of SLE. (Source: Inflammation Research)
Source: Inflammation Research - July 1, 2022 Category: Research Source Type: research
Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis?
ConclusionsThe different AH and plasma cytokine profiles observed in OS compared to Q + OS and TBU may help to differentiate OS from TBU in overlapping clinical phenotypes of granulomatous uveitis (Q + OS). (Source: Inflammation Research)
Source: Inflammation Research - June 28, 2022 Category: Research Source Type: research
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
AbstractA global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Meantime, cytokines recognize as crucial components in guiding the appropriate immune pathways in the restraining and eradication of the virus. Moreover, SARS-CoV-2 can induce uncontrolled inflammatory responses characterized by hyper-inflammatory cytokine production, which causes cytoki...
Source: Inflammation Research - June 25, 2022 Category: Research Source Type: research
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
ConclusionIt seems that photoaging and normal aging evoke similar processes driven by the remodeling of the immune system. However, it is likely that there are different molecular mechanisms inducing inflammation and immunosuppression in the accelerated photoaging and the chronological aging processes. (Source: Inflammation Research)
Source: Inflammation Research - June 24, 2022 Category: Research Source Type: research
Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway
ConclusionIn short, this study demonstrated that inhibition of Visfatin might alleviate sepsis-induced intestinal injury through Hippo signaling pathway, supporting a further research on Visfatin as a therapeutic target. (Source: Inflammation Research)
Source: Inflammation Research - June 22, 2022 Category: Research Source Type: research
The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer
ConclusionsWe found the combination of MetS and inflammation could significantly increase the risk of CRC. Including CRP in the diagnosis of MetS may help to identify additional high-risk participants who should be targeted for early diagnosis and prevention of CRC.Trial registrationKailuan study, ChiCTR –TNRC–11001489. Registered 24 August, 2011-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=8050 (Source: Inflammation Research)
Source: Inflammation Research - June 18, 2022 Category: Research Source Type: research
