Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases
ConclusionAccording to these preliminary observations, the addition of PV extract may stimulate the tissue regenerative and repair functions of MSCs. Further optimization of compound extraction and characterization from PV as well as cell treatment conditions should increase their therapeutic value in combination with MSCs. (Source: Inflammation Research)
Source: Inflammation Research - June 18, 2022 Category: Research Source Type: research
Particulate matter in COPD pathogenesis: an overview
AbstractChronic obstructive pulmonary disease (COPD) is a progressive lung disorder with substantial patient burden and leading cause of death globally. Cigarette smoke remains to be the most recognised causative factor behind COPD pathogenesis. Given the alarming increase in prevalence of COPD amongst non-smokers in recent past, a potential role of air pollution particularly particulate matter (PM) in COPD development has gained much attention of the scientists. Indeed, several epidemiological studies indicate strong correlation between airborne PM and COPD incidence/exacerbations. PM-induced oxidative stress seems to be ...
Source: Inflammation Research - June 16, 2022 Category: Research Source Type: research
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis
AbstractThe human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates selective autophagy including xenophagy and mitophagy. IRGM impacts autophagy by (1) affecting mitochondrial fusion and fission, (2) promoting the co-assembly of ULK1 and Beclin 1, (3) enhancing Beclin 1 interacting partners (AMBRA1, ATG14L1, and UVRAG), (4) interacting with other key proteins (ATG16L1, p62, NOD2, cGAS, TLR3, and RIG-I), and (5) regulating lysosomal biogenesis. IRGM also negatively regulates NLRP3 inflammasome formation and therefore, maturation of the important pro-inflammatory cytokine IL-1 β, impacting inflammati...
Source: Inflammation Research - June 14, 2022 Category: Research Source Type: research
Correction to: Bioinformatics analysis for identifying micro-RNAs, long noncoding RNAs, transcription factors, and immune genes regulatory networks in diabetic cardiomyopathy using an integrated bioinformatics analysis
(Source: Inflammation Research)
Source: Inflammation Research - June 10, 2022 Category: Research Source Type: research
Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators?
ConclusionThe critical and integrative analysis performed herein will certainly feed future research focused on the better comprehension of cachexia pathogenesis toward the improvement of its diagnosis and the development of personalized therapies targeting specific cachexia phenotypes. (Source: Inflammation Research)
Source: Inflammation Research - June 9, 2022 Category: Research Source Type: research
