CX3CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice
ConclusionsWe uncovered novel,Cx3cr1 deficiency-mediated pathogenic mechanisms contributing to SLE-associated glomerulonephritis and cardiovascular disease. (Source: Inflammation Research)
Source: Inflammation Research - April 15, 2023 Category: Research Source Type: research
Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis
ConclusionThe inactivation ofCalca and thereby PCT provided full protection from joint inflammation and arthritic bone loss in mice exposed to CAIA. Together with our previous findings on the pathophysiological function ofCalca-derived peptides, these data indicate an independent pro-inflammatory role of PCT in RA. (Source: Inflammation Research)
Source: Inflammation Research - April 11, 2023 Category: Research Source Type: research
Quercetin alleviates tubulointerstitial inflammation by inhibiting exosomes-mediated crosstalk between tubular epithelial cells and macrophages
ConclusionQuercetin could serve as a novel strategy for treatment of tubulointerstitial inflammation by inhibiting the exosomes-mediated crosstalk between tubules and macrophages. (Source: Inflammation Research)
Source: Inflammation Research - April 11, 2023 Category: Research Source Type: research
Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance
ConclusionIn this review, we will highlight recent advances in which artesunate can restore the Th17/Treg imbalance in disease states by altering T-cell metabolism to influence differentiation and lineage selection. Data from the current study show that few studies have focused on the effect of ART on cellular metabolism. ART can affect the metabolic characteristics of T cells (glycolysis, lipid metabolism, and amino acid metabolism) and interfere with their differentiation lineage, thereby regulating the balance of Th17/Treg and alleviating the symptoms of the disease. (Source: Inflammation Research)
Source: Inflammation Research - April 6, 2023 Category: Research Source Type: research
Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1 α
ConclusionGlycolysis provides additional energy to sustain Rho/ROCK activation in RA subjects, which promotes VEGF-driven angiogenesis and can be inhibited by SIRT1 activation. (Source: Inflammation Research)
Source: Inflammation Research - April 4, 2023 Category: Research Source Type: research
Integrative analysis of multi-omics data to identify three immune-related genes in the formation and progression of intracranial aneurysms
ConclusionThe present study demonstrated heightened immune response and suppressed ECM organization in aneurysm formation and rupture. The three-gene immune-related signature (CCR4, S100B, and OSM) model may facilitate IA diagnosis and prevention. (Source: Inflammation Research)
Source: Inflammation Research - April 4, 2023 Category: Research Source Type: research
Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine
ConclusionsDialysis is associated with an increased risk of severe COVID-19, and generally has a poor seroconversion response to vaccines. It also confirms the protective effect of vaccines on high-risk populations such as dialysis. (Source: Inflammation Research)
Source: Inflammation Research - April 1, 2023 Category: Research Source Type: research
Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38
ConclusionsOur findings uncover a key role for Imp7 in the process of p38 nuclear import after CS stimulation and highlight the potential of preventing p38 nuclear translocation in treatment of VILI. (Source: Inflammation Research)
Source: Inflammation Research - April 1, 2023 Category: Research Source Type: research
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data
ConclusionThese results suggest that AMP-related genes are closely involved in alterations of OA synovial inflammation. The transcriptional level of hub genes could serve as a potential diagnostic marker for OA. (Source: Inflammation Research)
Source: Inflammation Research - March 30, 2023 Category: Research Source Type: research
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19
ConclusionsPre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports. (Source: Inflammation Research)
Source: Inflammation Research - March 30, 2023 Category: Research Source Type: research
Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
ConclusionsOverall, these results indicated that curcumin has the potential to treat pruritus induced by mast cell MrgprB2 receptor. (Source: Inflammation Research)
Source: Inflammation Research - March 30, 2023 Category: Research Source Type: research
Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
AbstractThe blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils. (Source: Inflammation Research)
Source: Inflammation Research - March 29, 2023 Category: Research Source Type: research
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
ConclusionsBacSp222 is a novel ligand for TLR2/TLR6 heterodimer. By binding TLR complex the bacteriocin undergoes internalization, inducing proinflammatory signaling that employs MyD88 and NF- ĸB pathways. (Source: Inflammation Research)
Source: Inflammation Research - March 25, 2023 Category: Research Source Type: research
Increased sympathetic outflow induced by emotional stress aggravates myocardial ischemia –reperfusion injury via activation of TLR7/MyD88/IRF5 signaling pathway
ConclusionIncreased sympathetic outflow induced by emotional stress activates TLR7/MyD88/IRF5 signaling pathway, ultimately aggravating I/R injury. (Source: Inflammation Research)
Source: Inflammation Research - March 18, 2023 Category: Research Source Type: research
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients
ConclusionTreatment with colchicine inhibited the activation of the NLRP3 inflammasome, an event triggering the ‘cytokine storm’ in COVID-19.Trial registration numbersRBR-8jyhxh (Source: Inflammation Research)
Source: Inflammation Research - March 14, 2023 Category: Research Source Type: research
