Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2
ConclusionOur findings provide the rationale for further studies to evaluate whether targeting PAR-2 may be a clinically effective strategy to counteract endothelial dysfunction in COVID-19. (Source: Inflammation Research)
Source: Inflammation Research - December 20, 2023 Category: Research Source Type: research

Homer1 ameliorates ischemic stroke by inhibiting necroptosis-induced neuronal damage and neuroinflammation
ConclusionsHomer1 ameliorates ischemic stroke by inhibiting necroptosis-induced neuronal damage and neuroinflammation. These data suggested that Homer1 is a novel regulator of neuronal death and neuroinflammation. (Source: Inflammation Research)
Source: Inflammation Research - December 13, 2023 Category: Research Source Type: research

The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
ConclusionA certain therapeutic dose of metformin inhibited hyperinflammatory responses and alleviated immunosuppression in LPS-induced macrophages through the bidirectional modulation of intracellular ROS generation. (Source: Inflammation Research)
Source: Inflammation Research - December 13, 2023 Category: Research Source Type: research

Association of systemic inflammation with the obesity paradox in cancer: results from multi-cohort studies
ConclusionsThe obesity paradox is prevalent in most cancers, except for hepatic biliary cancer and breast cancer. Inflammation may be one of the true features of the obesity paradox in cancer. (Source: Inflammation Research)
Source: Inflammation Research - December 12, 2023 Category: Research Source Type: research

Ecto-5 ʹ-nucleotidase (CD73): an emerging role as prognostic factor in allergic sensitization
AbstractOver the years, the importance of the epithelium in the assessment of allergic sensitization and development of allergic diseases has increased. Sensitization to allergens appears to be influenced by genetic and external environmental factors. However, not all subjects exposed to environmental factors that damage epithelial cells suffer from allergic diseases. On this basis, identifying the signaling pathways that characterize the different phenotypes and endotypes of allergy is of high priority for a successful personalized therapy. Ecto-5 ʹ-nucleotidase/CD73 is a membrane-bound enzyme responsible for extracellul...
Source: Inflammation Research - December 12, 2023 Category: Research Source Type: research

The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients
ConclusionOur study found that immunosuppression occurs in patients early in sepsis. Early monitoring of the patient ’s immune status may provide a timely warning of the disease. (Source: Inflammation Research)
Source: Inflammation Research - December 12, 2023 Category: Research Source Type: research

Serine metabolism in macrophage polarization
ConclusionSerine metabolism coordinates multiple metabolic pathways to tailor macrophage polarization and their responses to different pathogenic attacks and thus holds the potential as therapeutic target for types of acute and chronic inflammatory diseases. (Source: Inflammation Research)
Source: Inflammation Research - December 9, 2023 Category: Research Source Type: research

Insights into the complex interactions between Rab22a and extracellular vesicles in cancers
AbstractIntroductionOncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with upstream, downstream molecules, and notably, extracellular vesicles (EVs). While the expansive family of Rabs and their associated signaling pathways have been exhaustively dissected, Rab22a emerges as an entity of outstanding interest, owing to its potent influence in many biological processes and its conspicuous correlation with cancer metastasis and migration. A burgeoning interest in the interactions between Rab22a and EVs in the field of oncology underscores the necessity for more...
Source: Inflammation Research - December 8, 2023 Category: Research Source Type: research

Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
ConclusionWe identified five cellular senescence-associated genes for atherogenesis progression and unveiled that ABI3 might promote macrophage senescence via activation of the NF- κB pathway in atherogenesis progression, which proposes new preventive and therapeutic strategies of senolytic agents for atherosclerosis. (Source: Inflammation Research)
Source: Inflammation Research - December 7, 2023 Category: Research Source Type: research

O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
ConclusionsOur findings identified a novel post-translational modification of GSDMD and elucidated theO-GlcNAcylation of GSDMD inhibits LPS-induced endothelial injury, suggesting thatO-GlcNAc modification-based treatments could serve as potential interventions for sepsis-associated vascular endothelial injury. (Source: Inflammation Research)
Source: Inflammation Research - November 14, 2023 Category: Research Source Type: research

Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
ConclusionThis review provides a thorough exploration of the pathological and physiological characteristics of three crucial glycolytic enzymes in RA. It delves into their putative regulatory mechanisms, shedding light on their significance in RAFLS. Furthermore, the review offers an up-to-date overview of emerging small-molecule candidate drugs designed to target these glycolytic enzymes and the upstream signaling pathways that regulate them. By enhancing our understanding of the pathogenic mechanisms of RA and highlighting the pivotal role of glycolytic enzymes, this study contributes to the development of innovative ant...
Source: Inflammation Research - November 8, 2023 Category: Research Source Type: research

Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
ConclusionsThis study unravels the role of p53R213* mutant in RA pathogenesis, and identifies TBK1 as a potential anti-inflammatory target. (Source: Inflammation Research)
Source: Inflammation Research - November 8, 2023 Category: Research Source Type: research

Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
ConclusionsLidocaine pretreatment can attenuate the  sepsis-induced ALI by an anti-inflammatory mechanism of inhibiting K+ efflux-dependent NLRP3 activation. (Source: Inflammation Research)
Source: Inflammation Research - November 6, 2023 Category: Research Source Type: research

Effects of neutrophil fate on inflammation
ConclusionInflammatory response and tissue damage can be aggravated when neutrophils are not removed rapidly from the site of injury. Recent studies have shown that neutrophils can be cleared through a variety of pathways, including non-inflammatory and inflammatory death, as well as reverse migration. Non-inflammatory death pathways include apoptosis and autophagy. Inflammatory death pathways include necroptosis, pyroptosis and NETosis. This review highlights the basic properties of neutrophils and the impact of their clearance pathways on the inflammatory response. (Source: Inflammation Research)
Source: Inflammation Research - November 5, 2023 Category: Research Source Type: research

Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
ConclusionWe examine the molecular mechanisms of IVDD-associated mitochondrial dysfunction and present novel directions for quality management of mitochondrial dysfunction as a treatment approach to IVDD. (Source: Inflammation Research)
Source: Inflammation Research - November 5, 2023 Category: Research Source Type: research