Immune response associated with ischemia and reperfusion injury during organ transplantation
ConclusionComprehension of the immune mechanisms involved in organ transplantation is promising for the treatment of IRI, this review summarizes the similarities and differences in both innate and adaptive immunity and advancements in the immune response associated with IRI during diverse organ transplantation. (Source: Inflammation Research)
Source: Inflammation Research - October 25, 2022 Category: Research Source Type: research
Immunosenescence of T cells: a key player in rheumatoid arthritis
AbstractIntroductionThe incidence of rheumatoid arthritis (RA) and its complications are expected to increase with age. Remarkably, RA patients were identified features of accelerated aging, particularly in immunosenescence. As is known, T cells in RA patients readily differentiate into pro-inflammatory phenotypes that maintain chronic and persistent inflammatory changes in joints and many other organ systems. Recent evidence suggests that T cells are most sensitive to aging, and aged CD4+ T cells contribute to inflammaging, which plays a crucial role in accelerating the disease process. In recent years, the molecular mech...
Source: Inflammation Research - October 25, 2022 Category: Research Source Type: research
CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans
ConclusionsIn summary, our data show that inA. xylosoxidans infection, the activation of CD14 induces intense pulmonary inflammatory response resulting in mice death. (Source: Inflammation Research)
Source: Inflammation Research - October 25, 2022 Category: Research Source Type: research
The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to air pollution
DiscussionWhen exposed to PM2.5, macrophages increase the production of reactive oxygen species, which activate nuclear factor-kappa B (NF- κB). NF-κB is naturally a pro-inflammatory factor that drives prostaglandin E2 (PGE2) synthesis and causes fever. PGE2 can be converted into prostaglandin A2, a powerful inducer of HSR. Therefore, when transiently activated, NF-κB can trigger the anti-inflammatory response through negative feedba ck, by inducing HSP70 expression. However, when chronically activated, NF-κB heads a set of pathways involved in mitochondrial dysfunction, endoplasmic reticulum stress, unfolded protein r...
Source: Inflammation Research - October 20, 2022 Category: Research Source Type: research
The inflammasomes: crosstalk between innate immunity and hematology
ConclusionDifferent blood cells variably express inflammasome components. Considering the immunosuppression associated with both the disease and the treatment of some hematologic diseases, and a microenvironment that allows neoplastic cell proliferation, inflammasomes could be a link between innate immunity and disease progression, as well as an interesting therapeutic target. (Source: Inflammation Research)
Source: Inflammation Research - October 20, 2022 Category: Research Source Type: research
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia –reperfusion injury
ConclusionsUSP7 inhibition attenuated I/R-induced renal injury by inhibiting ferroptosis through decreasing ubiquitination of TBK1 and promoting DNMT1-mediated methylation of FMR1. (Source: Inflammation Research)
Source: Inflammation Research - October 20, 2022 Category: Research Source Type: research
The role of lung macrophages in acute respiratory distress syndrome
AbstractAcute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury in a short time, one of the common severe manifestations of the respiratory system that endangers human life and health. As an innate immune cell, macrophages play a key role in the inflammatory response. For a long time, the role of pulmonary macrophages in ARDS has tended to revolve around the polarization of M1/M2. However, with the development of single-cell RNA sequencing, fate mapping, metabolomics, and other new technologies, a deeper understanding of the development process, classification, and function of macrophage...
Source: Inflammation Research - October 20, 2022 Category: Research Source Type: research
Retraction Note: Silencing of long non ‑coding RNA MALAT1 suppresses inflammation in septic mice: role of microRNA‑23a in the down‑regulation of MCEMP1 expression
(Source: Inflammation Research)
Source: Inflammation Research - October 19, 2022 Category: Research Source Type: research
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis
ConclusionsGut microbiota and LCA exerted synergistic anti-inflammatory effects on liver fibrosis. The combined intervention of gut microbiota and LCA will be a new strategy for treating liver fibrosis. (Source: Inflammation Research)
Source: Inflammation Research - September 17, 2022 Category: Research Source Type: research
A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1 α accumulation in the hypoxic microenvironment of synovium
ConclusionGE attenuates abnormal proliferation of RA-FLSs via inhibiting HIF-1 α accumulation through enhancement of PHD2 activity. (Source: Inflammation Research)
Source: Inflammation Research - September 15, 2022 Category: Research Source Type: research
IL10/AMPK pathway was associated with the hippocampal anti-inflammatory response to high-sugar and high-fat diet withdrawal
ConclusionOur analyses suggest that OD withdrawal increases serum inflammation with hippocampal consequent inflammatory alterations. Despite the general assumption that improving diet improves health, this may not be immediate. (Source: Inflammation Research)
Source: Inflammation Research - September 9, 2022 Category: Research Source Type: research
The role of adenosine A1 receptor on immune cells
ConclusionIn this review, we discussed the effects of A1R on immune cells, including monocytes, macrophages, neutrophils, dendritic cells, and microglia, and focused on the role of A1R in regulating immune cells in diseases, which may facilitate our understanding of the mechanisms by which adenosine affects immune cells through A1R. (Source: Inflammation Research)
Source: Inflammation Research - September 5, 2022 Category: Research Source Type: research
Retraction Note: Tripterine ameliorates monosodium urate crystal ‑induced gouty arthritis by altering macrophage polarization via the miR‑449a/NLRP3 axis
(Source: Inflammation Research)
Source: Inflammation Research - September 5, 2022 Category: Research Source Type: research
Retraction Note: Knockdown of long non ‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression
(Source: Inflammation Research)
Source: Inflammation Research - September 5, 2022 Category: Research Source Type: research
Novel insight into ferroptosis-related genes, molecular subtypes, and immune characteristics in intracranial aneurysms
ConclusionFerroptosis and the immune microenvironment are closely associated with IAs, providing a basis for understanding the IA development. (Source: Inflammation Research)
Source: Inflammation Research - September 4, 2022 Category: Research Source Type: research
