Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study
ConclusionElevated immune inflammation level on admission was an independent risk factor for all-cause, cardiovascular, and cancer mortality among CKD patients. Further research is needed to validate the predictive value of SII for mortality risk among CKD patients. (Source: Inflammation Research)
Source: Inflammation Research - November 9, 2022 Category: Research Source Type: research
Characterization of immune landscape and development of a novel N7-methylguanine-related gene signature to aid therapy in recurrent aphthous stomatitis
ConclusionsThe present study pictured a comprehensive immune infiltration landscape and suggested that m7G played a vital role in RAS through immune-related pathways. This study provided new insight for the future investigation of the mechanisms and therapeutic strategies for RAS. (Source: Inflammation Research)
Source: Inflammation Research - November 9, 2022 Category: Research Source Type: research
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain
ConclusionWe provide evidence that STING pathway activation leads to neuroinflammation and peripheral sensitization. Pharmacological blockade of STING may be a promising novel strategy for preventing BCP. (Source: Inflammation Research)
Source: Inflammation Research - November 8, 2022 Category: Research Source Type: research
Retraction Note to: Suppressors of cytokine signalling (SOCS) ‑1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells
(Source: Inflammation Research)
Source: Inflammation Research - November 8, 2022 Category: Research Source Type: research
PI3K γ controls IL-17A expression and attenuates alveolar bone loss in an experimental periodontitis model
ConclusionPI3K γ plays an important role in modulating IL-17A expression and alveolar bone loss in vivo and can be considered a promising pathway for the management of periodontal disease and the development of new therapies. (Source: Inflammation Research)
Source: Inflammation Research - November 4, 2022 Category: Research Source Type: research
Attenuation of experimental osteoarthritis with human adipose-derived mesenchymal stem cell therapy: inhibition of the pyroptosis in chondrocytes
ConclusionThese results demonstrated that hAD-MSCs could inhibit pyroptosis signaling pathway of chondrocytes induced by TNF- α, which have raised our understanding of the role of hAD-MSCs as promising therapy for the management of OA. (Source: Inflammation Research)
Source: Inflammation Research - November 4, 2022 Category: Research Source Type: research
Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea
ConclusionThe photobiomodulation effect of IPL for rosacea treatment may inhibit MC degranulation and alleviate inflammatory reactions. (Source: Inflammation Research)
Source: Inflammation Research - November 3, 2022 Category: Research Source Type: research
Gastrointestinal consequences of lipopolysaccharide-induced lung inflammation
ConclusionsIntratracheal LPS administration induces inflammation in the ileum that is associated with enhanced expression of EpCAM, decreased claudin-4 expression and increased goblet cell density, these changes may contribute to systemic inflammation that is known to accompany many inflammatory diseases of the lung. (Source: Inflammation Research)
Source: Inflammation Research - November 2, 2022 Category: Research Source Type: research
Interleukin-19 upregulates fibronectin and collagen I expression via the NF- κB-Smad2/3 pathway in fibroblasts of patients with chronic rhinosinusitis
ConclusionsIL-19 promotes FN and Col I production via the activated NF- κB-Smad2/3 pathway in fibroblasts, leading to fibrosis and collagen deposition in patients with CRS. (Source: Inflammation Research)
Source: Inflammation Research - November 1, 2022 Category: Research Source Type: research
Cytokine storm: behind the scenes of the collateral circulation after acute myocardial infarction
AbstractAt least 17 million people die from acute myocardial infarction (AMI) every year, ranking it first among causes of death of human beings, and its incidence is gradually increasing. Typical characteristics of AMI include acute onset and poor prognosis. At present, there is no satisfactory treatment, but development of coronary collateral circulation (CCC) can be key to improving prognosis. Recent research indicates that the levels of cytokines, including those related to promoting inflammatory responses and angiogenesis, increase after the onset of AMI. In the early phase of AMI, cytokines play a vital role in induc...
Source: Inflammation Research - October 28, 2022 Category: Research Source Type: research
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2 α/ATF4-mediated endoplasmic reticulum stress
ConclusionThe HMGB1-RAGE axis induces apoptotic injury during ARDS, possibly through PERK/eIF2 α/ATF4-mediated ERs. (Source: Inflammation Research)
Source: Inflammation Research - October 28, 2022 Category: Research Source Type: research
Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease
AbstractPatients with chronic kidney disease (CKD) are at higher risk for severe coronavirus disease 2019 (COVID-19). Such patients are more likely to develop “COVID-19-induced acute kidney injury (AKI)”, which exacerbates the pre-existing CKD and increases the mortality rate of the patients. COVID-19-induced AKI is pathologically characterized by acute tubular necrosis and the interstitial infiltration of proinflammatory leukocytes. In our rat model with advanced CKD, immunohistochemistry for angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) demonstrated their strong expression in th...
Source: Inflammation Research - October 28, 2022 Category: Research Source Type: research
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases
ConclusionsThis review provides an assessment of neutrophils and their crucial involvement in various chronic inflammatory disorders ranging from respiratory, neurodegenerative, autoimmune, and cardiovascular diseases. In addition, we also discuss the therapeutic approach for targeting neutrophils in disease settings that will pave the way forward for future research. (Source: Inflammation Research)
Source: Inflammation Research - October 26, 2022 Category: Research Source Type: research
Immune response associated with ischemia and reperfusion injury during organ transplantation
ConclusionComprehension of the immune mechanisms involved in organ transplantation is promising for the treatment of IRI, this review summarizes the similarities and differences in both innate and adaptive immunity and advancements in the immune response associated with IRI during diverse organ transplantation. (Source: Inflammation Research)
Source: Inflammation Research - October 25, 2022 Category: Research Source Type: research
Immunosenescence of T cells: a key player in rheumatoid arthritis
AbstractIntroductionThe incidence of rheumatoid arthritis (RA) and its complications are expected to increase with age. Remarkably, RA patients were identified features of accelerated aging, particularly in immunosenescence. As is known, T cells in RA patients readily differentiate into pro-inflammatory phenotypes that maintain chronic and persistent inflammatory changes in joints and many other organ systems. Recent evidence suggests that T cells are most sensitive to aging, and aged CD4+ T cells contribute to inflammaging, which plays a crucial role in accelerating the disease process. In recent years, the molecular mech...
Source: Inflammation Research - October 25, 2022 Category: Research Source Type: research
