Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies
AbstractBackgroundIntervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP), posing a significant socioeconomic burden. Recent studies highlight the crucial role of inflammatory microenvironment in IDD progression.MethodA keyword-based search was performed using the PubMed database for published articles.Results and conclusionsDysregulated expression of inflammatory cytokines disrupts intervertebral disc (IVD) homeostasis, causing atrophy, fibrosis, and phenotypic changes in nucleus pulposus cells. Modulating the inflammatory microenvironment and restoring cytokine balance hold promise for IVD repair...
Source: Inflammation Research - September 4, 2023 Category: Research Source Type: research
Associations between anthropometric parameters and immune-phenotypical characteristics of circulating Tregs and serum cytokines
ConclusionsAnthropometric measures are associated with Tregs and serum cytokine concentrations revealing new important interconnections between obesity and the adaptive immune system. (Source: Inflammation Research)
Source: Inflammation Research - September 2, 2023 Category: Research Source Type: research
Pirfenidone ameliorates liver steatosis by targeting the STAT3-SCD1 axis
ConclusionIn summary, our data reveal that PFD may play an important role in mitigating hepatic steatosis in a STAT3-SCD1-dependent manner. (Source: Inflammation Research)
Source: Inflammation Research - September 2, 2023 Category: Research Source Type: research
Multimodal data-driven prognostic model for predicting new-onset ST-elevation myocardial infarction following emergency percutaneous coronary intervention
ConclusionsOur prediction nomogram based on multi-modal data (inflammatory indices, clinical and imaging data) reliably predicted in-hospital MACCEs in new-onset STEMI patients with emergency PCI. This prediction nomogram can enable individualized treatment strategies. (Source: Inflammation Research)
Source: Inflammation Research - August 29, 2023 Category: Research Source Type: research
Geniposide augments apoptosis in fibroblast-like synoviocytes by restoring hypoxia-enhanced JNK-BNIP3-mediated autophagy
ConclusionGE inhibited autophagy by restoring the hypoxia-induced activated JNK-BNIP3 pathway, inducing mitochondrial oxidative damage, augmented apoptosis, and decreased survival rate of FLSs. (Source: Inflammation Research)
Source: Inflammation Research - August 25, 2023 Category: Research Source Type: research
A novel CD8+ T cell-related gene signature for predicting the prognosis and immunotherapy efficacy in bladder cancer
ConclusionsCD8+ T cell-related molecular clusters were successfully identified. Besides, a novel CD8+ T cell-related prognostic model with an excellent predictive performance in predicting survival rates and immunotherapy efficacy of BCa was developed. (Source: Inflammation Research)
Source: Inflammation Research - August 14, 2023 Category: Research Source Type: research
Resolving neutrophils due to TRAM deletion renders protection against experimental sepsis
ConclusionsNeutrophils with TRAM deletion render effective reprogramming into a resolving state beneficial for ameliorating experimental sepsis, with therapeutic potential in propagating cellular and tissue homeostasis as well as treating sepsis. (Source: Inflammation Research)
Source: Inflammation Research - August 10, 2023 Category: Research Source Type: research
Monogenic autoinflammatory disease-associated cardiac damage
AbstractIntroductionAutoinflammatory diseases (AIDs) constitute several disorders that are characterized by the presence of recurrent episodes of unprovoked inflammation due to dysregulated innate immune system in the absence of autoantibodies or infections. Most of them have a strong genetic background, with mutations in single genes involved in inflammation referred to monogenic AIDs. In this article, we will review the cardiac manifestations in various monogenic AIDs.Areas coveredVarious cardiac manifestations can be seen in various monogenic AIDs, including pericarditis, valvular diseases, coronary diseases, cardiomyop...
Source: Inflammation Research - August 10, 2023 Category: Research Source Type: research
BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis
ConclusionBI 1291583-mediated inhibition of CatC is expected to restore the protease –antiprotease balance in the lungs of patients with chronic airway inflammatory diseases such as bronchiectasis. (Source: Inflammation Research)
Source: Inflammation Research - August 4, 2023 Category: Research Source Type: research
ACE2, ACE, DPPIV, PREP and CAT L enzymatic activities in COVID-19: imbalance of ACE2/ACE ratio and potential RAAS dysregulation in severe cases
ConclusionOur findings reveal a correlation between proteases activity and the severity of COVID-19. These enzymes together contribute to the activation of pro-inflammatory pathways, trigger a systemic activation of inflammatory mediators, leading to a RAAS dysregulation and generating a significant damage in several organs, contributing to poor outcomes of severe cases. (Source: Inflammation Research)
Source: Inflammation Research - August 3, 2023 Category: Research Source Type: research
Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes
ConclusionsAlthough ANA-positivity was found to be increased in MDS, the low ANA-antigenic-specificity suggests that autoantibodies didn ’t recognize autoimmune-pathognomonic antigens. The lack of relationship between genetic profile and ANA-positivity, suggests that MDS genetic variants may not be the direct cause of SIAD. (Source: Inflammation Research)
Source: Inflammation Research - July 28, 2023 Category: Research Source Type: research
Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund ’s adjuvant-induced paw inflammation model
ConclusionThe biological role of ALOX15 in the pathogenesis of inflammation is variable and depends on the kind of the animal inflammation model. (Source: Inflammation Research)
Source: Inflammation Research - July 27, 2023 Category: Research Source Type: research
Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection
ConclusionsCollectively, we revealed spatial proteomics and immune signature of LN kidney regions by combined using LCM and DIA. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2023 Category: Research Source Type: research
The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4+ T cells
ConclusionOur findings may help to elucidate novel mechanisms of the H2R and to achieve a better understanding of the role of GZMB in the pathogenesis of AD. (Source: Inflammation Research)
Source: Inflammation Research - July 20, 2023 Category: Research Source Type: research
Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors
ConclusionsWe demonstrate that injured skeletal muscle tissues have a better repair capacity with less fibrosis in the presence of B2 receptor and absence of B1 receptor, including better performances in functional tests. (Source: Inflammation Research)
Source: Inflammation Research - July 18, 2023 Category: Research Source Type: research
