From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases
ConclusionIn this review, we summarize the molecular structure and the action mechanisms of LAG3. Additionally, we highlight its roles in diverse autoimmune diseases and discuss how the manipulation of the LAG3 pathway can serve as a promising therapeutic strategy as well as its specific mechanism with the aim of filling the gaps from bench to bedside. (Source: Inflammation Research)
Source: Inflammation Research - June 14, 2023 Category: Research Source Type: research
Lupus nephritis or not? A simple and clinically friendly machine learning pipeline to help diagnosis of lupus nephritis
ConclusionWe developed and validated a new and simple machine learning pathway for diagnosis of LN, especially the XGB model based on ASO, LA1, LA2, proteinuria, and other features screened out by collective feature selection. (Source: Inflammation Research)
Source: Inflammation Research - June 10, 2023 Category: Research Source Type: research
Dual role of ANGPTL4 in inflammation
Conclusion:Understanding the potential underlying mechanisms of ANGPTL4 in inflammation in different tissues and diseases will aid in drug discovery and treatment development. (Source: Inflammation Research)
Source: Inflammation Research - June 10, 2023 Category: Research Source Type: research
Challenges and opportunities in animal models of psoriatic arthritis
ConclusionsThe animal models of PsA aim to mimic the clinicopathological alterations of PsA patients through gene mutation, transgenesis or targeted proinflammatory factor and to reveal new pathogenic pathways and therapeutic targets by exploring the pathological features and clinical manifestations of the disease. This work will have very far-reaching implications for the in-depth understanding of PsA and the development of new drugs. (Source: Inflammation Research)
Source: Inflammation Research - June 10, 2023 Category: Research Source Type: research
Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages
ConclusionsOur study demonstrated that strong biofilmP. aeruginosa strains, CF isolates, are dominant inducers of M1 macrophages, termed biofilm-associated macrophages (BAMs). We suggest that repolarization of detrimental BAMs might be a new therapeutic strategy to ameliorate the airway damage in CF. (Source: Inflammation Research)
Source: Inflammation Research - May 31, 2023 Category: Research Source Type: research
Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation
ConclusionNeutrophil sub-populations differ among diseases and hence, mechanisms regulating formation, sustenance, proportions and functions of these sub-types vary between physiological and pathological conditions. Hence, mechanistic insights of neutrophil subsets in disease specific manner may facilitate development of neutrophil-targeted therapies. (Source: Inflammation Research)
Source: Inflammation Research - May 22, 2023 Category: Research Source Type: research
New small molecules in dermatology: for the autoimmunity, inflammation and beyond
ConclusionsDespite having lower specificity compared to specific immunobiological therapies, these new drugs are effective in a wide variety of dermatological diseases, especially diseases that had few therapeutic options, such as psoriasis, psoriatic arthritis, atopic dermatitis, alopecia areata, and vitiligo. (Source: Inflammation Research)
Source: Inflammation Research - May 22, 2023 Category: Research Source Type: research
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis
ConclusionRhein promoted macrophage M2 polarization transition by targeting the NFATc1/Trem2 axis to regulate inflammation response and prognosis after ALI/ARDS, which shed more light on possibilities for the clinical treatments of this pathological process. (Source: Inflammation Research)
Source: Inflammation Research - May 22, 2023 Category: Research Source Type: research
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes
(Source: Inflammation Research)
Source: Inflammation Research - May 19, 2023 Category: Research Source Type: research
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF- κB signaling pathway activation in aged mice
ConclusionFluoxetine pretreatment suppressed hippocampal neuroinflammation and mitigated POCD by inhibiting microglial TLR4/MyD88/NF- κB pathway activation in aged mice. (Source: Inflammation Research)
Source: Inflammation Research - May 15, 2023 Category: Research Source Type: research
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation
ConclusionsOur results demonstrate thatH. pylori VacA antibody is the only causal determinant associated with the risk of stroke in the spectrum ofH. pylori-related antibodies, in which CRP may mediate the association. This study suggests that inhibition of the CRP signaling pathway may reduce the risk of stroke in patients with VacA-positiveH. pylori infection. (Source: Inflammation Research)
Source: Inflammation Research - May 15, 2023 Category: Research Source Type: research
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
ConclusionThese findings indicate that CDKN2A mediates the resistance of fibrosis-promoting M2 macrophages to cuproptosis and promotes pulmonary fibrosis in mice. Our work provides fresh insights into CRGs in IPF with potential value for research in the pathogenesis, diagnosis, and a new therapy strategy for IPF. (Source: Inflammation Research)
Source: Inflammation Research - May 11, 2023 Category: Research Source Type: research
4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition
Conclusion4-OI ameliorates BLM-induced PF in an Nrf2-dependent manner, and its role in alleviating PF is partly due to the direct inhibition on EMT, and partly through indirect inhibition of M2-mediated EMT. These findings suggested that 4-OI has great clinical potential to develop as a new anti-fibrotic agent for PF therapy. (Source: Inflammation Research)
Source: Inflammation Research - May 11, 2023 Category: Research Source Type: research
Efficacy of Janus kinase inhibitors in rheumatoid arthritis
ConclusionSome clinical, biological and imaging parameters seem to influence the response to JAKis and should be evaluated in larger studies. In addition to factors that might influence the efficacy of JAKis, the safety profile and risk factors should be considered before initiating JAKis in a patient. (Source: Inflammation Research)
Source: Inflammation Research - April 22, 2023 Category: Research Source Type: research
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma
ConclusionOur findings imply that the lipid-related gene CH25H may be a useful biomarker in the diagnosis of asthma. (Source: Inflammation Research)
Source: Inflammation Research - April 20, 2023 Category: Research Source Type: research
