Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice
ConclusionPKR inhibition using C16 accelerates the wound healing process in diabetic mice by decreasing NALP3-mediated IL-1 β maturation. (Source: Inflammation Research)
Source: Inflammation Research - November 23, 2022 Category: Research Source Type: research
A common variant close to the “tripwire” linker region of NLRP1 contributes to severe COVID-19
ConclusionInflammasome genetic background contributes to individual response to SARS-CoV-2. (Source: Inflammation Research)
Source: Inflammation Research - November 23, 2022 Category: Research Source Type: research
Multi-target regulation of pro-inflammatory cytokine production by transcription factor Blimp-1
ConclusionBlimp-1 represses the production of multiple pro-inflammatory cytokines by directly binding the genomic region and restricting the nuclear translocation and transcriptional activity of NF- κB. This finding may provide potential therapeutic strategies for the cytokine storm-related diseases. (Source: Inflammation Research)
Source: Inflammation Research - November 20, 2022 Category: Research Source Type: research
FK506 impairs neutrophil migration that results in increased polymicrobial sepsis susceptibility
ConclusionOur data indicate that the increased susceptibility to infection of FK506-treated mice is associated with failed neutrophil migration due to the reduced membrane availability of CXCR2 receptors in response to exacerbated levels of circulating CXCL2. (Source: Inflammation Research)
Source: Inflammation Research - November 19, 2022 Category: Research Source Type: research
Stress analysis of self-tightness metal sealing against ultrahigh pressure medium
AbstractStress is one of the most important factors in metal-to-metal sealing. In this paper, two methods (theoretical and empirical) were adopted to calculate the normal stress of the brass sealing surfaces against different ultrahigh pressure liquid. The theoretical formula was derived in terms of force balance, and the empirical formula was obtained by polynomial curve fitting, which the fitted data were from simulated results; besides, the results calculated using the empirical formula agree well with the results by theoretical formula. Meanwhile, the equivalent stresses of the brass seal, normal stress and contact str...
Source: Inflammation Research - November 17, 2022 Category: Research Source Type: research
Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review
ConclusionThis review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, what contributes as a basis for choosing compounds and directing the further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
RCAN1 deficiency aggravates sepsis-induced cardiac remodeling and dysfunction by accelerating mitochondrial pathological fission
ConclusionsOur finding demonstrated that RCAN1 deficiency aggravated mitochondrial injury and septic cardiomyopathy through activating CaMKII. RCAN1 serves as a novel therapeutic target for treatment of sepsis-related cardiac remodeling and dysfunction. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF- κB signaling pathway
ConclusionsCollectively, lncGBP9 knockdown exerts anti-inflammatory and anti-apoptotic effects in CVB3-induced AVMC, which may be mediated in part via NF- κB signaling pathway. These findings highlight lncGBP9 as an attractive target for therapeutic interventions. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sj ögren syndrome
ConclusionThis study elucidated the molecular mechanism underlying the effect of GITRL in regulating the function of MDSCs, which may provide a new therapeutic target for the treatment of pSS. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate
ConclusionHistamine produced by HDC-induction mainly in infiltrated neutrophils stimulates H4Rs, leading to augmented Ale + LPS-induced ear-swelling via MCP-1 production by MCs. Since MCP-1 is produced by other cells, too, the contribution of MCs and their H4Rs to augmented ear-swelling is partial. In the later phase of the swelling, MCs may be anti-inflammatory via IL-10 production. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
C/EBP β enhances immunosuppression activity of myeloid-derived suppressor cells by a P300-mediated acetylation modification
ConclusionIn general, a P300-mediated C/EBP β acetylation enhanced C/EBPβ transactivation activity onArg-1 promoter, thus promoting immunosuppressive function of MDSCs. In view of the critical role of P300 in regulating MDSCs, P300 might be a potential target of anti-tumor immunotherapy. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review
ConclusionIn this review, we comprehensively discussed the effects of miR-155, including role of miR-155 in different downstream signaling, which then differently regulate immune cells expression and functions. Furthermore, miR-155-mediated dysfunction of immune cells contributed to development of inflammatory autoimmune diseases. Therefore, miR-155 is expected to be a therapeutic target for inflammatory autoimmune diseases. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
Low 15d-PGJ2 status is associated with oxidative stress in chronic obstructive pulmonary disease patients
ConclusionsSerum 15d-PGJ2 and pulmonary PPAR γ are reduced, and oxidative stress is elevated in COPD patients. Serum 15d-PGJ2 is inversely associated with oxidative stress in COPD patients. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation
ConclusionsThese results emphasize the importance of further research to accurately identify the anti-inflammatory mechanism of action of chalcones. (Source: Inflammation Research)
Source: Inflammation Research - November 12, 2022 Category: Research Source Type: research
Albiflorin attenuates high glucose-induced endothelial apoptosis via suppressing PARP1/NF- κB signaling pathway
ConclusionsAlbiflorin suppressed high glucose-induced endothelial cell apoptosis and inflammation, suggesting its potential in treating diabetic vascular complications. The action of albiflorin possibly caused by its regulation on inhibiting PARP1/NF- κB signaling. (Source: Inflammation Research)
Source: Inflammation Research - November 10, 2022 Category: Research Source Type: research
