The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells
ConclusionsTRPA1 expression and function in lung epithelial cells was upregulated under inflammatory conditions. IFN- γ further increased TRPA1 expression while IL-4 and IL-13 suppressed that in a JAK-STAT6 dependent manner which is novel. TRPA1 also modulated the expression of genes relevant to innate immunity and lung disease. We propose that the paradigm of Th1 and Th2 inflammation is a major determinant of TRP A1 expression and function, which should be considered when targeting TRPA1 for pharmacotherapy in inflammatory (lung) disease. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2023 Category: Research Source Type: research
CTRP12 ameliorates post-myocardial infarction heart failure through down-regulation of cardiac apoptosis, oxidative stress and inflammation by influencing the TAK1-p38 MAPK/JNK pathway
ConclusionsCTRP12 protects against post-MI HF by modulating the TAK1-p38 MAPK/JNK pathway. CTRP12 may be a therapeutic target for the treatment of post-MI HF. (Source: Inflammation Research)
Source: Inflammation Research - June 29, 2023 Category: Research Source Type: research
Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions
AbstractBackgroundRhoG is a multifaceted member of the Rho family of small GTPases, sharing the highest sequence identity with the Rac subfamily members. It acts as a molecular switch, when activated, plays a central role in regulating the fundamental processes in immune cells, such as actin-cytoskeleton dynamics, transendothelial migration, survival, and proliferation, including immunological functions (e.g., phagocytosis and trogocytosis) during inflammatory responses.MethodWe have performed a literature review based on published original and review articles encompassing the significant effect of RhoG on immune cell func...
Source: Inflammation Research - June 28, 2023 Category: Research Source Type: research
SHP2: its association and roles in systemic lupus erythematosus
ConclusionIn summary, SHP2 correlated with SLE pathogenesis and promoted the development of lupus. (Source: Inflammation Research)
Source: Inflammation Research - June 23, 2023 Category: Research Source Type: research
Exosomal MiR-381 from M2-polarized macrophages attenuates urethral fibroblasts activation through YAP/GLS1-regulated glutaminolysis
ConclusionCollectively, this study demonstrates that exosomal miR-381 from M2-polarized macrophages reduces myofibroblast formation of UFBs and urethral scarring and stricture by inhibiting YAP/GLS1-dependent glutaminolysis. (Source: Inflammation Research)
Source: Inflammation Research - June 21, 2023 Category: Research Source Type: research
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3 β/Nrf2 signaling cascade
ConclusionsUp-regulation of CaMKK2 provides a therapeutic benefit in the rat model of MI/R injury by boosting the Nrf2 pathway through regulation of AMPK/AKT/GSK-3 β, which suggests CaMKK2 as a new molecular target for the treatment of MI/R injury. (Source: Inflammation Research)
Source: Inflammation Research - June 20, 2023 Category: Research Source Type: research
A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis
ConclusionsThe present study is the first to reveal the critical roles of the alarmin S100A8/A9 in the immunopathology ofCandida albicans keratitis, highlighting a promising approach for therapeutic intervention in the future. (Source: Inflammation Research)
Source: Inflammation Research - June 19, 2023 Category: Research Source Type: research
Staphylococci planktonic and biofilm environments differentially affect osteoclast formation
ConclusionOur data indicate that the biofilm environment and its high lactate levels are not actively promoting osteoclastogenesis. Hence, the inflammatory immune response against planktonic bacterial factors through Toll-like receptors seems to be the central cause for the pathological osteoclast formation. Therefore, immune stimulation or approaches that aim at biofilm disruption need to consider that this might result in enhanced inflammation-mediated bone destruction. (Source: Inflammation Research)
Source: Inflammation Research - June 17, 2023 Category: Research Source Type: research
Paradoxical expression of NRP1 in decidual stromal and immune cells reveals a novel inflammation balancing mechanism during early pregnancy
ConclusionNRP1 is a multifunctional controller that balances the inflammatory states of DSCs and DICs in gravid uterus. Abnormal expression of NRP1 is implicated in miscarriage. (Source: Inflammation Research)
Source: Inflammation Research - June 16, 2023 Category: Research Source Type: research
Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFN β1 transcription during macrophage activation
ConclusionOur results demonstrated that inhibiting TRIM24 promoted the expression of IFN β1 and IL-10 during macrophage activation, therefore protecting mice from endotoxic shock. This study offers novel insights into the regulatory role of TRIM24 in IL-10 expression, making it a potentially attractive therapeutic target for inflammatory diseases. (Source: Inflammation Research)
Source: Inflammation Research - June 16, 2023 Category: Research Source Type: research
STING deficiency protects against wasp venom-induced acute kidney injury
ConclusionsSTING activation mediates the inflammatory response in wasp venom-induced AKI. This may offer a potential therapeutic target for the management of wasp venom-induced AKI. (Source: Inflammation Research)
Source: Inflammation Research - June 16, 2023 Category: Research Source Type: research
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis
ConclusionsTREM-1 represents a potentially novel therapeutic target and we identify miR-150-5p as one of the mechanisms to alleviate lupus disease, which is attributable for inhibiting mDCs activation through TREM-1 signaling pathway. (Source: Inflammation Research)
Source: Inflammation Research - June 16, 2023 Category: Research Source Type: research
Agmatine-IRF2BP2 interaction induces M2 phenotype of microglia by increasing IRF2-KLF4 signaling
ConclusionsTaken together, unbound IRF2, resulting from the competitive binding of Agm to IRF2BP2, may provide neuroprotection against neuroinflammation via an anti-inflammatory mechanism of microglia involving the expression of KLF4. (Source: Inflammation Research)
Source: Inflammation Research - June 14, 2023 Category: Research Source Type: research
From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases
ConclusionIn this review, we summarize the molecular structure and the action mechanisms of LAG3. Additionally, we highlight its roles in diverse autoimmune diseases and discuss how the manipulation of the LAG3 pathway can serve as a promising therapeutic strategy as well as its specific mechanism with the aim of filling the gaps from bench to bedside. (Source: Inflammation Research)
Source: Inflammation Research - June 14, 2023 Category: Research Source Type: research
Lupus nephritis or not? A simple and clinically friendly machine learning pipeline to help diagnosis of lupus nephritis
ConclusionWe developed and validated a new and simple machine learning pathway for diagnosis of LN, especially the XGB model based on ASO, LA1, LA2, proteinuria, and other features screened out by collective feature selection. (Source: Inflammation Research)
Source: Inflammation Research - June 10, 2023 Category: Research Source Type: research
