Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics
ConclusionCurrent evidence and reports indicate the direct relation between SARS-CoV-2 infection and bone health and thus warrant future research in this field. It would be imperative to assess the post-COVID-19 fracture risk of SARS-CoV-2-infected individuals by simultaneously monitoring them for bone metabolism/biochemical markers. Importantly, several emerging research suggest that dysbiosis of the gut microbiota —GM (established role in inflammatory bone loss conditions) is further involved in the severity of COVID-19 disease. In the present review, we thus also highlight the importance of dietary interventions inclu...
Source: Inflammation Research - August 17, 2022 Category: Research Source Type: research
Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF- κB signaling pathway
ConclusionOur study highlighted a regulatory network consisting of SRF, ANXA2, and NF- κB that was involved in AP progression, possibly providing some novel targets for treating SAP. (Source: Inflammation Research)
Source: Inflammation Research - August 17, 2022 Category: Research Source Type: research
Type 2 alveolar epithelial cell-derived circulating extracellular vesicle-encapsulated surfactant protein C as a mediator of cardiac inflammation in COVID-19
AbstractAmong the countless endeavours made at elucidating the pathogenesis of COVID-19, those aimed at the histopathological alterations of type 2 alveolar epithelial cells (AT2) are of outstanding relevance to the field of lung physiology, as they are the building blocks of the pulmonary alveoli. A merit of high regenerative and proliferative capacity, exocytotic activity resulting in the release of extracellular vesicles (EVs) is particularly high in AT2 cells, especially in those infected with SARS-CoV-2. These AT2 cell-derived EVs, containing the genetic material of the virus, might enter the bloodstream and make thei...
Source: Inflammation Research - August 17, 2022 Category: Research Source Type: research
Review: the role of GSDMD in sepsis
ConclusionCombined with the pathogenesis of sepsis, it is not difficult to find that pyroptosis plays a key role in bacterial inflammation and sepsis. Therefore, GSDMD inhibitors may be used as targeted drugs to treat sepsis by reducing the occurrence of pyroptosis. This review mainly discusses the key role of GSDMD in sepsis. (Source: Inflammation Research)
Source: Inflammation Research - August 15, 2022 Category: Research Source Type: research
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice
ConclusionThis study can provide significant insight into the proteomics-guided pharmacological mechanism study of CFZ and suggest potential therapeutic strategies for infectious disease. (Source: Inflammation Research)
Source: Inflammation Research - August 13, 2022 Category: Research Source Type: research
Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPAR γ and reducing NOX4 expression
ConclusionThese findings highlighted that knockdown of TRIM27 alleviated sepsis-induced inflammation, oxidative stress and apoptosis via suppressing ubiquitination of PPAR γ and reducing NOX4 expression, which supports the potential utility of TRIM27 as a therapeutic target in septic lung injury. (Source: Inflammation Research)
Source: Inflammation Research - August 13, 2022 Category: Research Source Type: research
Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study
ConclusionsCAR is an effective representative of systemic inflammation and a powerful factor for predicting the life function and clinical outcome of patients with cancer cachexia. (Source: Inflammation Research)
Source: Inflammation Research - August 13, 2022 Category: Research Source Type: research
CD20+ T cells: an emerging T cell subset in human pathology
ConclusionThis review summarises the latest understanding of CD20+T cells, their presence in various diseases, their putative function and how they may be an ongoing target of CD20-depleting agents. Unfortunately, our understanding of these cells is still at its infancy and ongoing study in a wider range of pathologies is required. (Source: Inflammation Research)
Source: Inflammation Research - August 11, 2022 Category: Research Source Type: research
Lipoxin alleviates oxidative stress: a state-of-the-art review
ConclusionLipoxin is provided with a protective role in attenuating oxidative stress. (Source: Inflammation Research)
Source: Inflammation Research - August 10, 2022 Category: Research Source Type: research
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail
ConclusionsAs a result, fenofibrate could be a potential treatment approach for COVID-19 control. (Source: Inflammation Research)
Source: Inflammation Research - August 8, 2022 Category: Research Source Type: research
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway
ConclusionsThese results indicated that RNF2 is a potent pro-fibrogenic molecule for PFbs activation and proliferation through mTOR and p16-CDK4-Rb signaling pathways, and RNF2 inhibition will be a potential therapeutic avenue for treating PF. (Source: Inflammation Research)
Source: Inflammation Research - August 6, 2022 Category: Research Source Type: research
Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4R α
ConclusionsmiR-124-3p might attenuate type 2 inflammation in AR by regulating IL-4R α signaling, and miR-124-3p may be a promising new target in AR treatment. (Source: Inflammation Research)
Source: Inflammation Research - August 3, 2022 Category: Research Source Type: research
Human mast cells induce osteoclastogenesis through cell surface RANKL
ConclusionOur study provided direct evidence confirming the initiation of osteoclast proliferation and activation by mast cells through cell surface RANKL suggesting that mast cells may contribute to bone destruction in pathological conditions such as osteoporosis. (Source: Inflammation Research)
Source: Inflammation Research - August 2, 2022 Category: Research Source Type: research
STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model
ConclusionsTwo different types of Ly6c-expressing macrophages are induced in the inflamed tissues through the IFN- α/β-STAT1-mediated CCL2/CCR2 cascade and this is associated with the pathogenesis such as onset, exacerbation, and subsequent chronicity of acute colitis. (Source: Inflammation Research)
Source: Inflammation Research - August 1, 2022 Category: Research Source Type: research
Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway
ConclusionExtracellular histones induce inflammation and senescence in VSMCs, and blocking the AMPK/FOXO4 pathway is a potential target for the treatment of histonemediated organ injury. (Source: Inflammation Research)
Source: Inflammation Research - August 1, 2022 Category: Research Source Type: research
