RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway

ConclusionsThese results indicated that RNF2 is a potent pro-fibrogenic molecule for PFbs activation and proliferation through mTOR and p16-CDK4-Rb signaling pathways, and RNF2 inhibition will be a potential therapeutic avenue for treating PF.

http://link.springer.com/10.1007/s00011-022-01617-8

Source: Inflammation Research - August 6, 2022 Category: Research Source Type: research