Neuroinflammatory mediators in acquired epilepsy: an update
Abstract
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are commonly characterized by spontaneous seizures and behavioral comorbidities. Although the mechanisms underlying the epileptic seizures mostly remain poorly understood and the causes often can be idiopathic, a considerable portion of cases are known as acquired epilepsy. This form of epilepsy is typically associated with prior neurological insults, which lead to the initiation and progression of epileptogenesis, eventually resulting in unprovoked seizures. A convergence of evidence in the past two decades suggests that inf...
Source: Inflammation Research - February 6, 2023 Category: Research Source Type: research
Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH
ConclusionsA subgroup of Vsig4+ resident single-KCs was shown to improve hepatic inflammation and fibrosis in NASH. (Source: Inflammation Research)
Source: Inflammation Research - February 6, 2023 Category: Research Source Type: research
IL-33 induces histidine decarboxylase, especially in c-kit+ cells and mast cells, and roles of histamine include negative regulation of IL-33-induced eosinophilia
ConclusionIL-33 directly and indirectly (via IL-5) induces HDC in various cells, particularly potently in c-kit+ cells and mature mast cells, and the newly formed histamine contributes to the negative regulation of IL-33-induced eosinophilia via H4Rs. (Source: Inflammation Research)
Source: Inflammation Research - February 1, 2023 Category: Research Source Type: research
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells
ConclusionDistinct exocytic pathways exist in mast cells for the release of different mediators. (Source: Inflammation Research)
Source: Inflammation Research - February 1, 2023 Category: Research Source Type: research
The potential role of N6-methyladenosine modification of LncRNAs in contributing to the pathogenesis of chronic glomerulonephritis
ConclusionsOur findings provide a basis and novel insight for further investigations of m6A modifications in LncRNAs for the pathogenesis of CGN. (Source: Inflammation Research)
Source: Inflammation Research - January 26, 2023 Category: Research Source Type: research
γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization
ConclusionCollectively, both in vivo and in vitro experiments suggested that γ-GC has the potential to become a promising novel therapeutic dipeptide for the treatment of IBD, which provide new ideas for the treatment of inflammatory diseases in the future. (Source: Inflammation Research)
Source: Inflammation Research - January 24, 2023 Category: Research Source Type: research
Uncovering the role of transient receptor potential channels in pterygium: a machine learning approach
ConclusionsOur study suggested that TRP channels played an essential role in the pathogenesis of pterygium. The identified pivotal biomarkers (especially MCOLN3) and pathways provide novel directions for future mechanistic and therapeutic studies for pterygium. (Source: Inflammation Research)
Source: Inflammation Research - January 24, 2023 Category: Research Source Type: research
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A
ConclusionWnt5A has been shown to be involved in all three inflammatory lung diseases. Since the ligand affects both structural and immunological processes, it is an interesting target for the treatment of lung diseases whose pathology involves a restructuring of the lung tissue triggered in part by an inflammatory immune response. (Source: Inflammation Research)
Source: Inflammation Research - January 19, 2023 Category: Research Source Type: research
Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK
ConclusionConclusively, BMSC-derived EV-encapsulated miR-223-3p mitigated AKI-induced inflammation and pyroptosis by targeting HDAC2 and promoting SNRK transcription. (Source: Inflammation Research)
Source: Inflammation Research - January 14, 2023 Category: Research Source Type: research
Eosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergy
ConclusionsWe should maintain a high level of suspicion about other differential diagnosis involving eosinophilia and IgE dysregulation, especially in patients very young (when innate errors of the immunity may present) and in middle to elderly patients classified as having atopic dermatitis, due to the possibility of cutaneous hematological malignancies, paraneoplasia or autoimmune blistering diseases. (Source: Inflammation Research)
Source: Inflammation Research - January 13, 2023 Category: Research Source Type: research
TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance
ConclusionsThese data reveal that the frequency and characteristics of the TCRβ chain CDR3 undergo dynamic programming under conditions of LPS tolerance. Furthermore, the peripheral macrophages may be a key factor which carry peripheral antigen to thymic medulla and affect the negative selection of T-cell population, thereby contributing to the formation of ET. These results suggest that the clone selection in thymus in ET may confer protection against microbial sepsis. (Source: Inflammation Research)
Source: Inflammation Research - January 12, 2023 Category: Research Source Type: research
circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p
ConclusionOur findings showed that circFLNA promotes intestinal injury in abdominal sepsis through the Fas-mediated apoptosis pathway by sponging miR-766-3p. The circFLNA/miR-766-3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis. (Source: Inflammation Research)
Source: Inflammation Research - January 10, 2023 Category: Research Source Type: research
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and putative therapeutic targets in COVID-19 patients
ConclusionsU-CysLT increase during hospitalization in critical COVID-19 patients, especially in hypertensives on VV-ECMO. U-CysLT association with severe outcomes suggests their usefulness for prognostication and as therapeutic targets. (Source: Inflammation Research)
Source: Inflammation Research - January 8, 2023 Category: Research Source Type: research
Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway
ConclusionThe findings suggest that gp130 regulates the inflammatory response and cell apoptosis through the JAK1/STAT3 signaling pathway, thereby mitigating LPS-induced lung injury. Gp130 may be a potential therapeutic target for ALI/ARDS. (Source: Inflammation Research)
Source: Inflammation Research - January 8, 2023 Category: Research Source Type: research
Inflammation, coagulation, and cellular injury in heat-induced shock
ConclusionsMultiple mechanisms are involved in the pathogenesis of heat-induced shock. In addition to dehydration, heat stress-induced cardiomyopathy due to the thermal damage of mitochondria, upregulated inflammation via damage-associated molecular patterns released from oncotic cells, unbalanced coagulation/fibrinolysis, and endothelial damage are the major factors that are related to circulatory shock. (Source: Inflammation Research)
Source: Inflammation Research - January 7, 2023 Category: Research Source Type: research
