SS-31 inhibits mtDNA –cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
ConclusionsSS-31 conferred neuroprotection against POCD by promoting PHB2-mediated mitophagy activation to inhibit mtDNA release, which in turn suppressed the cGAS –STING pathway and M1 microglial polarization. (Source: Inflammation Research)
Source: Inflammation Research - February 27, 2024 Category: Research Source Type: research
Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction
ConclusionsCollectively, these studies reveal VMP1 as a negative regulator of inflammatory responses, and we postulate that decreased expression of VMP1 can aggravate the inflammatory sequelae associated with neurodegenerative diseases like PD. (Source: Inflammation Research)
Source: Inflammation Research - February 27, 2024 Category: Research Source Type: research
Interleukin-19 enhances eosinophil infiltration through upregulation of epithelium-derived RANTES expression via the ERK/NF- κB signalling pathway in patients with eosinophilic CRSwNP
ConclusionsOur findings indicate that IL-19 promotes RANTES expression via the ERK/NF- κB pathway in HNECs and is implicated in eosinophil infiltration in patients with Eos CRSwNP. (Source: Inflammation Research)
Source: Inflammation Research - February 23, 2024 Category: Research Source Type: research
Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps
ConclusionsINPP4A deficiency promotes macrophage polarization towards the M2 phenotype, leading to the secretion of chemokines that recruit eosinophils and Th2 cells, thereby amplifying eosinophilic inflammation in E-CRSwNP. INPP4A may exert a suppressive role in eosinophilic inflammation and could potentially serve as a novel therapeutic strategy. (Source: Inflammation Research)
Source: Inflammation Research - February 16, 2024 Category: Research Source Type: research
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
ConclusionsCBL0137 alone or plus inflammatory stimulation induces PANoptosis both in vitro and in vivo, which is associated with systemic inflammatory responses in mice. (Source: Inflammation Research)
Source: Inflammation Research - February 14, 2024 Category: Research Source Type: research
Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice
ConclusionsThese findings reveal that anti-CD20 mAb treatment alleviates Th2 cell responses, possibly by depleting lung FM B cells in a Th2-driven asthma model. This implies a potential therapeutic approach for asthma treatment through the targeting of lung FM B cells. (Source: Inflammation Research)
Source: Inflammation Research - February 12, 2024 Category: Research Source Type: research
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
ConclusionThe latest strides made in research about intestinal organoids help elucidate intricate aspects of IBD pathogenesis, and pave the prospective avenues for novel therapeutic interventions. (Source: Inflammation Research)
Source: Inflammation Research - February 12, 2024 Category: Research Source Type: research
Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk
ConclusionsThis Mendelian randomization analysis underscores the pivotal role of PCSK9 in the etiology of psoriatic arthritis. Inhibition of PCSK9 is associated with reduced psoriatic arthritis risk, highlighting the potential therapeutic benefits of existing PCSK9 inhibitors. (Source: Inflammation Research)
Source: Inflammation Research - February 11, 2024 Category: Research Source Type: research
CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection
ConclusionData suggest a causal link between cytokines (risk factor), lung damage (mediator), and COVID-19 outcomes. (Source: Inflammation Research)
Source: Inflammation Research - February 3, 2024 Category: Research Source Type: research
Identification of inflammatory biomarkers in IgA nephropathy using the NanoString technology: a validation study in Caucasians
ConclusionsOur findings validate our NanoString mRNA profiling by examining protein expression levels of two candidate genes,C3 andTNFRSF1B, in IgAN patients and controls. We also identified several upregulated mRNA transcripts implicated in the development of fibrosis that may be considered fibrotic markers within IgAN patients. (Source: Inflammation Research)
Source: Inflammation Research - January 31, 2024 Category: Research Source Type: research
Identification of RRM2 as a key ferroptosis-related gene in sepsis
ConclusionRRM2 plays an important role in sepsis and may contribute to sepsis through the ferroptosis pathway. This study provides potential therapeutic targets for sepsis. (Source: Inflammation Research)
Source: Inflammation Research - January 29, 2024 Category: Research Source Type: research
Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity
ConclusionsVarious immune components of the innate immune system play critical roles in lung injury after ischemia/reperfusion. Preventing cell death and the release of DAMPs, interrupting DAMPs receptor interactions, disrupting intracellular inflammatory signaling pathways, and minimizing immune cell recruitment are essential for lung protection in LIRI. (Source: Inflammation Research)
Source: Inflammation Research - January 24, 2024 Category: Research Source Type: research
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis
ConclusionsMST1 reduces the survival, migration, invasion and inflammation of FLSs by inhibiting the SIRT3/mTOR axis to reduce mitochondrial autophagy and promote mitochondrial division, thereby achieving the potential role of relieving rheumatoid arthritis. (Source: Inflammation Research)
Source: Inflammation Research - January 24, 2024 Category: Research Source Type: research
Endoplasmic reticulum stress interferes with the development of type 1 regulating T cells
ConclusionsThe synergistic effects of ER stress and MNP interfere with the development of Tr1 cells. The development of Tr1 from CD4+ CD25− T cells in patients with UC is re-established by Rnf20 inhibition. (Source: Inflammation Research)
Source: Inflammation Research - January 24, 2024 Category: Research Source Type: research
A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis
ConclusionsThe results of our study support a significant role of cell adhesion molecules in mediating the interplay between RA and atherosclerosis. Further studies are warranted to determine whether the routine use of these biomarkers can facilitate the detection and management of early atherosclerosis in this patient group.PROSPERO Registration Number: CRD42023466662. (Source: Inflammation Research)
Source: Inflammation Research - January 19, 2024 Category: Research Source Type: research
