Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation

ConclusionsOur results demonstrate thatH. pylori VacA antibody is the only causal determinant associated with the risk of stroke in the spectrum ofH. pylori-related antibodies, in which CRP may mediate the association. This study suggests that inhibition of the CRP signaling pathway may reduce the risk of stroke in patients with VacA-positiveH. pylori infection.
Source: Inflammation Research - Category: Research Source Type: research