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Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F 1 F O -ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells
Eur J Cell Biol. 2024 Feb 15;103(2):151398. doi: 10.1016/j.ejcb.2024.151398. Online ahead of print.ABSTRACTNaringenin (NRG) was characterized for its ability to counteract mitochondrial dysfunction which is linked to cardiovascular diseases. The F1FO-ATPase can act as a molecular target of NRG. The interaction of NRG with this enzyme can avoid the energy transmission mechanism of ATP hydrolysis, especially in the presence of Ca2+ cation used as cofactor. Indeed, NRG was a selective inhibitor of the hydrophilic F1 domain displaying a binding site overlapped with quercetin in the inside surface of an annulus made by the thre...
Source: European Journal of Cell Biology - February 18, 2024 Category: Cytology Authors: Salvatore Nesci Cristina Algieri Matteo Antonio Tallarida Rosita Stanzione Saverio Marchi Donatella Pietrangelo Fabiana Trombetti Luca D'Ambrosio Maurizio Forte Maria Cotugno Ilaria Nunzi Rachele Bigi Loredana Maiuolo Antonio De Nino Paolo Pinton Giovanni Source Type: research

Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma
Eur J Cell Biol. 2024 Feb 12;103(2):151396. doi: 10.1016/j.ejcb.2024.151396. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy that accounts for more than 90% of pancreatic cancer diagnoses. Our research is focused on the physico-chemical properties of the tumour microenvironment (TME), including its tumoural extracellular matrix (tECM), as they may have an important impact on the success of cancer therapies. PDAC xenografts and their decellularized tECM offer a great material source for research in terms of biomimicry with the original human tumour. Our aim was ...
Source: European Journal of Cell Biology - February 15, 2024 Category: Cytology Authors: Elena Garc ía-Gareta Alejandro Calder ón-Villalba Pilar Alam án-Díez Carlos Gracia Costa Pedro Enrique Guerrero Carlota Mur Ana Rueda Flores Nerea Olivera Jurjo Patricia Sancho Mar ía Ángeles Pérez Jos é Manuel García-Aznar Source Type: research

Thrombospondin 4, a mediator and candidate indicator of pain
Eur J Cell Biol. 2024 Feb 6;103(2):151395. doi: 10.1016/j.ejcb.2024.151395. Online ahead of print.ABSTRACTPain is the most common symptom for which patients seek medical attention. Existing treatments for pain control are largely ineffective due to the lack of an accurate way to objectively measure pain intensity and a poor understanding of the etiology of pain. Thrombospondin 4(TSP4), a member of the thrombospondin gene family, is expressed in neurons and astrocytes and induces pain by interacting with the calcium channel alpha-2-delta-1 subunit (Cavα2δ1). In the present study we show that TSP4 expression level correlat...
Source: European Journal of Cell Biology - February 10, 2024 Category: Cytology Authors: Yanqiong Wu Min Yang Xueqin Xu Yan Gao Xiaohui Li Yang Li Shanchun Su Xianqiao Xie Zeyong Yang Changbin Ke Source Type: research

The nexus of nuclear envelope dynamics, circular economy and cancer cell pathophysiology
Eur J Cell Biol. 2024 Feb 6;103(2):151394. doi: 10.1016/j.ejcb.2024.151394. Online ahead of print.ABSTRACTThe nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis. Nuclear architecture construction and deconstruction is a prime example of a circular economy, as it fulfills a highly efficient recycling program bound to continuous assessment of the quality and functionality of the building blocks. Alterations in the nuclear dynamics and lamina structure have emerged as important co...
Source: European Journal of Cell Biology - February 10, 2024 Category: Cytology Authors: Kristina Keuper Jiri Bartek Apolinar Maya-Mendoza Source Type: research

High throughput methods to study protein-protein interactions during host-pathogen interactions
Eur J Cell Biol. 2024 Jan 24;103(2):151393. doi: 10.1016/j.ejcb.2024.151393. Online ahead of print.ABSTRACTThe ability of a pathogen to survive and cause an infection is often determined by specific interactions between the host and pathogen proteins. Such interactions can be both intra- and extracellular and may define the outcome of an infection. There are a range of innovative biochemical, biophysical and bioinformatic techniques currently available to identify protein-protein interactions (PPI) between the host and the pathogen. However, the complexity and the diversity of host-pathogen PPIs has led to the development ...
Source: European Journal of Cell Biology - February 2, 2024 Category: Cytology Authors: Giridhar Chandrasekharan Meera Unnikrishnan Source Type: research

Regulation of the HIF switch in human endothelial and cancer cells
Eur J Cell Biol. 2024 Jan 20;103(2):151386. doi: 10.1016/j.ejcb.2024.151386. Online ahead of print.ABSTRACTHypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metabolic change facilitates normal cell survival as well as cancer cell survival. The key feature in survival is the transition between acute hypoxia and chronic hypoxia, and this is regulated by the transition between HIF-1 expre...
Source: European Journal of Cell Biology - January 23, 2024 Category: Cytology Authors: Jakub Slawski Maciej Ja śkiewicz Anna Barton Sylwia Kozio ł James F Collawn Rafa ł Bartoszewski Source Type: research

Helical motors and formins synergize to compact chiral filopodial bundles: A theoretical perspective
Eur J Cell Biol. 2024 Mar;103(1):151383. doi: 10.1016/j.ejcb.2023.151383. Epub 2024 Jan 11.ABSTRACTChiral actin bundles have been shown to play an important role in cell dynamics, but our understanding of the molecular mechanisms which combine to generate chirality remains incomplete. To address this, we numerically simulate a crosslinked filopodial bundle under the actions of helical myosin motors and/or formins and examine the collective buckling and twisting of the actin bundle. We first show that a number of proposed mechanisms to buckle polymerizing actin bundles without motor activity fail under biologically-realisti...
Source: European Journal of Cell Biology - January 18, 2024 Category: Cytology Authors: Ondrej Maxian Alex Mogilner Source Type: research

Corrigendum to "Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H 2 O 2 and iron" [Eur. J. Cell Biol. 102 (2023) 151346]
Eur J Cell Biol. 2024 Mar;103(1):151385. doi: 10.1016/j.ejcb.2024.151385. Epub 2024 Jan 15.NO ABSTRACTPMID:38228445 | DOI:10.1016/j.ejcb.2024.151385 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - January 16, 2024 Category: Cytology Authors: M Suzuki-Karasaki Y Ochiai S Innami H Okajima H Nakayama Y Suzuki-Karasaki Source Type: research

A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches
Eur J Cell Biol. 2024 Mar;103(1):151380. doi: 10.1016/j.ejcb.2023.151380. Epub 2023 Dec 28.ABSTRACTBacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been identified, but obtaining the quantitative information needed for a mechanistic understanding can often not be achieved from e...
Source: European Journal of Cell Biology - January 13, 2024 Category: Cytology Authors: Philipp Radler Martin Loose Source Type: research

Controling the cytoskeleton during CEACAM3-mediated phagocytosis
Eur J Cell Biol. 2024 Mar;103(1):151384. doi: 10.1016/j.ejcb.2024.151384. Epub 2024 Jan 5.ABSTRACTPhagocytosis, an innate defense mechanism of multicellular animals, is initiated by specialized surface receptors. A phagocytic receptor expressed by human polymorphonuclear granulocytes, the major professional phagocytes in our body, is one of the fastest evolving human proteins implying a special role in human biology. This receptor, CEACAM3, is a member of the CarcinoEmbryonic Antigen-related Cell Adhesion Molecule (CEACAM) family and dedicated to the immediate recognition and rapid internalization of human-restricted patho...
Source: European Journal of Cell Biology - January 12, 2024 Category: Cytology Authors: Johannes W P Kuiper Helena L Gregg Meike Sch über Jule Klein Christof R Hauck Source Type: research

Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation
Eur J Cell Biol. 2024 Mar;103(1):151381. doi: 10.1016/j.ejcb.2023.151381. Epub 2023 Dec 29.ABSTRACTThe facultative intracellular pathogen Shigella flexneri invades non-phagocytic epithelial gut cells. Through a syringe-like apparatus called type 3 secretion system, it injects effector proteins into the host cell triggering actin rearrangements leading to its uptake within a tight vacuole, termed the bacterial-containing vacuole (BCV). Simultaneously, Shigella induces the formation of large vesicles around the entry site, which we refer to as infection-associated macropinosomes (IAMs). After entry, Shigella ruptures the BCV...
Source: European Journal of Cell Biology - January 6, 2024 Category: Cytology Authors: Lisa Sanchez Arthur Lensen Michael G Connor M élanie Hamon Jost Enninga Camila Valenzuela Source Type: research

Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation
Eur J Cell Biol. 2023 Dec 29;103(1):151381. doi: 10.1016/j.ejcb.2023.151381. Online ahead of print.ABSTRACTThe facultative intracellular pathogen Shigella flexneri invades non-phagocytic epithelial gut cells. Through a syringe-like apparatus called type 3 secretion system, it injects effector proteins into the host cell triggering actin rearrangements leading to its uptake within a tight vacuole, termed the bacterial-containing vacuole (BCV). Simultaneously, Shigella induces the formation of large vesicles around the entry site, which we refer to as infection-associated macropinosomes (IAMs). After entry, Shigella ruptures...
Source: European Journal of Cell Biology - January 6, 2024 Category: Cytology Authors: Lisa Sanchez Arthur Lensen Michael G Connor M élanie Hamon Jost Enninga Camila Valenzuela Source Type: research