Biological roles of plant synaptotagmins
Eur J Cell Biol. 2023 Jun 20;102(3):151335. doi: 10.1016/j.ejcb.2023.151335. Online ahead of print.ABSTRACTPlant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They are characterized by an N-terminal transmembrane region and C2 domains at the C-terminus, which tether the ER to the plasma membrane (PM). In addition to their tethering role, SYTs contain a lipid-harboring SMP domain, essential for shuttling lipids between the ER and the PM. There is now abundant literature on Arabidopsis SYT1, the best-characterized family member, which link it to biotic and abiotic responses as well as to ER m...
Source: European Journal of Cell Biology - June 30, 2023 Category: Cytology Authors: Francisco Benitez-Fuente Miguel A Botella Source Type: research
Vitamin D < sub > 3 < /sub > protects against respiratory syncytial virus-induced barrier dysfunction in airway epithelial cells via PKA signaling pathway
Eur J Cell Biol. 2023 Jun 22;102(3):151336. doi: 10.1016/j.ejcb.2023.151336. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants and young children globally and is responsible for hospitalization and mortality in the elderly population. Virus-induced airway epithelial barrier damage is a critical step during RSV infection, and emerging studies suggest that RSV disrupts the tight junctions (TJs) and adherens junctions (AJs) between epithelial cells, increasing the permeability of the airway epithelial barrier. The lack of commercially ava...
Source: European Journal of Cell Biology - June 24, 2023 Category: Cytology Authors: Nannan Gao Andjela Raduka Fariba Rezaee Source Type: research
Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells
Eur J Cell Biol. 2023 Jun 17;102(3):151334. doi: 10.1016/j.ejcb.2023.151334. Online ahead of print.ABSTRACTThe development of epithelial-to-mesenchymal transition (EMT) like features is emerging as a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However, the extracellular signals and the signalling pathways in AML that may regulate EMT remain largely unstudied. We found that the bone marrow (BM) mesenchymal/fibroblastic cell line HS5 induces an EMT-like migratory phenotype in AML cells. AML cells underwent a strong increase of vimentin (VIM) levels that was not mirrored to the same extent b...
Source: European Journal of Cell Biology - June 24, 2023 Category: Cytology Authors: N Nojszewska O Idilli D Sarkar Z Ahouiyek Y Arroyo-Berdugo C Sandoval M S Amin-Anjum S Bowers D Greaves L Saeed M Khan S Salti S Al-Shami H Topoglu J K Punzalan J G Farias Y Calle Source Type: research
Vitamin D < sub > 3 < /sub > protects against respiratory syncytial virus-induced barrier dysfunction in airway epithelial cells via PKA signaling pathway
Eur J Cell Biol. 2023 Jun 22;102(3):151336. doi: 10.1016/j.ejcb.2023.151336. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants and young children globally and is responsible for hospitalization and mortality in the elderly population. Virus-induced airway epithelial barrier damage is a critical step during RSV infection, and emerging studies suggest that RSV disrupts the tight junctions (TJs) and adherens junctions (AJs) between epithelial cells, increasing the permeability of the airway epithelial barrier. The lack of commercially ava...
Source: European Journal of Cell Biology - June 24, 2023 Category: Cytology Authors: Nannan Gao Andjela Raduka Fariba Rezaee Source Type: research
Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells
Eur J Cell Biol. 2023 Jun 17;102(3):151334. doi: 10.1016/j.ejcb.2023.151334. Online ahead of print.ABSTRACTThe development of epithelial-to-mesenchymal transition (EMT) like features is emerging as a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However, the extracellular signals and the signalling pathways in AML that may regulate EMT remain largely unstudied. We found that the bone marrow (BM) mesenchymal/fibroblastic cell line HS5 induces an EMT-like migratory phenotype in AML cells. AML cells underwent a strong increase of vimentin (VIM) levels that was not mirrored to the same extent b...
Source: European Journal of Cell Biology - June 24, 2023 Category: Cytology Authors: N Nojszewska O Idilli D Sarkar Z Ahouiyek Y Arroyo-Berdugo C Sandoval M S Amin-Anjum S Bowers D Greaves L Saeed M Khan S Salti S Al-Shami H Topoglu J K Punzalan J G Farias Y Calle Source Type: research
