Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
CONCLUSION: ORs might be promising drug target candidates for lung diseases with non-type 2 inflammation. Their stimulation might reduce inflammation or prevent tissue remodeling by promoting wound healing.PMID:38583306 | DOI:10.1016/j.ejcb.2024.151408 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - April 7, 2024 Category: Cytology Authors: Daniel Weidinger Julian Jacobsen Desiree Alisch Hendrik Uebner Natalie Heinen Lea Greune Saskia Westhoven Kaschin Jamal Jameel Juliane Kronsbein Stephanie Pfaender Christian Taube Sebastian Reuter Marcus Peters Hanns Hatt J ürgen Knobloch Source Type: research
Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
CONCLUSION: ORs might be promising drug target candidates for lung diseases with non-type 2 inflammation. Their stimulation might reduce inflammation or prevent tissue remodeling by promoting wound healing.PMID:38583306 | DOI:10.1016/j.ejcb.2024.151408 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - April 7, 2024 Category: Cytology Authors: Daniel Weidinger Julian Jacobsen Desiree Alisch Hendrik Uebner Natalie Heinen Lea Greune Saskia Westhoven Kaschin Jamal Jameel Juliane Kronsbein Stephanie Pfaender Christian Taube Sebastian Reuter Marcus Peters Hanns Hatt J ürgen Knobloch Source Type: research
Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
CONCLUSION: ORs might be promising drug target candidates for lung diseases with non-type 2 inflammation. Their stimulation might reduce inflammation or prevent tissue remodeling by promoting wound healing.PMID:38583306 | DOI:10.1016/j.ejcb.2024.151408 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - April 7, 2024 Category: Cytology Authors: Daniel Weidinger Julian Jacobsen Desiree Alisch Hendrik Uebner Natalie Heinen Lea Greune Saskia Westhoven Kaschin Jamal Jameel Juliane Kronsbein Stephanie Pfaender Christian Taube Sebastian Reuter Marcus Peters Hanns Hatt J ürgen Knobloch Source Type: research
Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
CONCLUSION: ORs might be promising drug target candidates for lung diseases with non-type 2 inflammation. Their stimulation might reduce inflammation or prevent tissue remodeling by promoting wound healing.PMID:38583306 | DOI:10.1016/j.ejcb.2024.151408 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - April 7, 2024 Category: Cytology Authors: Daniel Weidinger Julian Jacobsen Desiree Alisch Hendrik Uebner Natalie Heinen Lea Greune Saskia Westhoven Kaschin Jamal Jameel Juliane Kronsbein Stephanie Pfaender Christian Taube Sebastian Reuter Marcus Peters Hanns Hatt J ürgen Knobloch Source Type: research
Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles
Eur J Cell Biol. 2024 Apr 5;103(2):151411. doi: 10.1016/j.ejcb.2024.151411. Online ahead of print.ABSTRACTEfficient degradation of phagocytic cargo in lysosomes is crucial to maintain cellular homeostasis and defending cells against pathogens. However, the mechanisms underlying the degradation and recycling of macromolecular cargo within the phagolysosome remain incompletely understood. We previously reported that the phagolysosome containing the corpse of the polar body in C. elegans tubulates into small vesicles to facilitate corpse clearance, a process that requires cargo protein degradation and amino acid export. Here ...
Source: European Journal of Cell Biology - April 6, 2024 Category: Cytology Authors: Rebecca Holzapfel Agata Prell Fabian Schumacher Veronika Perschin Jos é Pedro Friedmann Angeli Burkhard Kleuser Christian Stigloher Gholamreza Fazeli Source Type: research
Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles
Eur J Cell Biol. 2024 Apr 5;103(2):151411. doi: 10.1016/j.ejcb.2024.151411. Online ahead of print.ABSTRACTEfficient degradation of phagocytic cargo in lysosomes is crucial to maintain cellular homeostasis and defending cells against pathogens. However, the mechanisms underlying the degradation and recycling of macromolecular cargo within the phagolysosome remain incompletely understood. We previously reported that the phagolysosome containing the corpse of the polar body in C. elegans tubulates into small vesicles to facilitate corpse clearance, a process that requires cargo protein degradation and amino acid export. Here ...
Source: European Journal of Cell Biology - April 6, 2024 Category: Cytology Authors: Rebecca Holzapfel Agata Prell Fabian Schumacher Veronika Perschin Jos é Pedro Friedmann Angeli Burkhard Kleuser Christian Stigloher Gholamreza Fazeli Source Type: research
Damage control of epithelial barrier function in dynamic environments
Eur J Cell Biol. 2024 Apr 3;103(2):151410. doi: 10.1016/j.ejcb.2024.151410. Online ahead of print.ABSTRACTEpithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged like cobblestones and intricately bind together to form an epithelial sheet that upholds this barrier function. Central to the restriction of solute and fluid diffusion through intercellular spaces are occluding junctions, ti...
Source: European Journal of Cell Biology - April 5, 2024 Category: Cytology Authors: Tomohito Higashi Akira C Saito Hideki Chiba Source Type: research
Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology
Eur J Cell Biol. 2024 Mar 31;103(2):151409. doi: 10.1016/j.ejcb.2024.151409. Online ahead of print.ABSTRACTNeuromuscular junctions transmit signals from the nervous system to skeletal muscles, triggering their contraction, and their proper organization is essential for breathing and voluntary movements. αDystrobrevin-1 is a cytoplasmic component of the dystrophin-glycoprotein complex and has pivotal functions in regulating the integrity of muscle fibers and neuromuscular junctions. Previous studies identified that αDystrobrevin-1 functions in the organization of the neuromuscular junction and that its phosphorylation in ...
Source: European Journal of Cell Biology - April 5, 2024 Category: Cytology Authors: Teresa De Cicco Marcin P ęziński Olga W ójcicka Bhola Shankar Pradhan Margareta Jab łońska Klemens Rottner Tomasz J Pr ószyński Source Type: research
Damage control of epithelial barrier function in dynamic environments
Eur J Cell Biol. 2024 Apr 3;103(2):151410. doi: 10.1016/j.ejcb.2024.151410. Online ahead of print.ABSTRACTEpithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged like cobblestones and intricately bind together to form an epithelial sheet that upholds this barrier function. Central to the restriction of solute and fluid diffusion through intercellular spaces are occluding junctions, ti...
Source: European Journal of Cell Biology - April 5, 2024 Category: Cytology Authors: Tomohito Higashi Akira C Saito Hideki Chiba Source Type: research
Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology
Eur J Cell Biol. 2024 Mar 31;103(2):151409. doi: 10.1016/j.ejcb.2024.151409. Online ahead of print.ABSTRACTNeuromuscular junctions transmit signals from the nervous system to skeletal muscles, triggering their contraction, and their proper organization is essential for breathing and voluntary movements. αDystrobrevin-1 is a cytoplasmic component of the dystrophin-glycoprotein complex and has pivotal functions in regulating the integrity of muscle fibers and neuromuscular junctions. Previous studies identified that αDystrobrevin-1 functions in the organization of the neuromuscular junction and that its phosphorylation in ...
Source: European Journal of Cell Biology - April 5, 2024 Category: Cytology Authors: Teresa De Cicco Marcin P ęziński Olga W ójcicka Bhola Shankar Pradhan Margareta Jab łońska Klemens Rottner Tomasz J Pr ószyński Source Type: research
Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)
Eur J Cell Biol. 2024 Mar 26;103(2):151407. doi: 10.1016/j.ejcb.2024.151407. Online ahead of print.ABSTRACTWe analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly. NET-formation by dHL-60 cells and neutrophils was induced by Ionomycin or phorbol-12-myristat-13-acetate (PMA). Subsequent staining with anti-actin and TRITC-phalloidin showed depolymerization of the cortical F-actin at spatially confined areas, the NET extrusion sites, effected by transient activati...
Source: European Journal of Cell Biology - March 31, 2024 Category: Cytology Authors: Hans Georg Mannherz Heidi Budde Muhammad Jarkas Roua Hassoun Natalia Malek-Chudzik Antonina J Mazur Jelena Skuljec Refik Pul Markus Napirei Nazha Hamdani Source Type: research
Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)
Eur J Cell Biol. 2024 Mar 26;103(2):151407. doi: 10.1016/j.ejcb.2024.151407. Online ahead of print.ABSTRACTWe analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly. NET-formation by dHL-60 cells and neutrophils was induced by Ionomycin or phorbol-12-myristat-13-acetate (PMA). Subsequent staining with anti-actin and TRITC-phalloidin showed depolymerization of the cortical F-actin at spatially confined areas, the NET extrusion sites, effected by transient activati...
Source: European Journal of Cell Biology - March 31, 2024 Category: Cytology Authors: Hans Georg Mannherz Heidi Budde Muhammad Jarkas Roua Hassoun Natalia Malek-Chudzik Antonina J Mazur Jelena Skuljec Refik Pul Markus Napirei Nazha Hamdani Source Type: research
Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)
Eur J Cell Biol. 2024 Mar 26;103(2):151407. doi: 10.1016/j.ejcb.2024.151407. Online ahead of print.ABSTRACTWe analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly. NET-formation by dHL-60 cells and neutrophils was induced by Ionomycin or phorbol-12-myristat-13-acetate (PMA). Subsequent staining with anti-actin and TRITC-phalloidin showed depolymerization of the cortical F-actin at spatially confined areas, the NET extrusion sites, effected by transient activati...
Source: European Journal of Cell Biology - March 31, 2024 Category: Cytology Authors: Hans Georg Mannherz Heidi Budde Muhammad Jarkas Roua Hassoun Natalia Malek-Chudzik Antonina J Mazur Jelena Skuljec Refik Pul Markus Napirei Nazha Hamdani Source Type: research
Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)
Eur J Cell Biol. 2024 Mar 26;103(2):151407. doi: 10.1016/j.ejcb.2024.151407. Online ahead of print.ABSTRACTWe analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly. NET-formation by dHL-60 cells and neutrophils was induced by Ionomycin or phorbol-12-myristat-13-acetate (PMA). Subsequent staining with anti-actin and TRITC-phalloidin showed depolymerization of the cortical F-actin at spatially confined areas, the NET extrusion sites, effected by transient activati...
Source: European Journal of Cell Biology - March 31, 2024 Category: Cytology Authors: Hans Georg Mannherz Heidi Budde Muhammad Jarkas Roua Hassoun Natalia Malek-Chudzik Antonina J Mazur Jelena Skuljec Refik Pul Markus Napirei Nazha Hamdani Source Type: research
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Eur J Cell Biol. 2024 Mar 21;103(2):151406. doi: 10.1016/j.ejcb.2024.151406. Online ahead of print.ABSTRACTDespite extensive research, targeted delivery of substances to the brain still poses a great challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require either carrier- or receptor-mediated transport systems to reach the central nervous system (CNS). These transport systems form attractive routes for the delivery of therapeutics into the CNS, yet the number of known brain endothelium-enriched receptors allowing the transport of large molecules into the brain is scarce. Therefore, to ident...
Source: European Journal of Cell Biology - March 28, 2024 Category: Cytology Authors: Magdalena Kurtyka Frank Wessely Sarah Bau Eseoghene Ifie Liqun He Nienke M de Wit Alberte Bay Villekj ær Pedersen Maximilian Keller Caleb Webber Helga E de Vries Olaf Ansorge Christer Betsholtz Marijke De Bock Catarina Chaves Birger Brodin Morten S Niels Source Type: research
