RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
N-glycosylation at N57/100/110 affects CD44s localization, function and stability in hepatocellular carcinoma
Eur J Cell Biol. 2023 Sep 9;102(4):151360. doi: 10.1016/j.ejcb.2023.151360. Online ahead of print.ABSTRACTThe glycosylation levels of proteins in cancer cells are closely related to cancer invasion and migration. CD44 is a transmembrane glycoprotein that is significantly overexpressed in a variety of tumor cells and has been proven to promote the migration and motility of cancer cells, but the effect of its N-glycosylation modification on CD44 protein function in tumors is less studied. Here, we investigated the effect of six N-glycan chains (N25/57/100/110/120/255) on CD44s localization, function and stability in hepatoca...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Qixiang Cheng Xibo Hu Xiaoqing Zhang Depeng Yang Guiping Zhao Liping Sun Meiyi Jiang Lijun Yang Jialing Cai Bing Wang Mengmeng Zhang Fang Han Yu Li Huan Nie Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
Regulation of integrin α5β1-mediated Staphylococcus aureus cellular invasion by the septin cytoskeleton
Eur J Cell Biol. 2023 Sep 3;102(4):151359. doi: 10.1016/j.ejcb.2023.151359. Online ahead of print.ABSTRACTStaphylococcus aureus, a Gram-positive bacterial pathogen, is an urgent health threat causing a wide range of clinical infections. Originally viewed as a strict extracellular pathogen, accumulating evidence has revealed S. aureus to be a facultative intracellular pathogen subverting host cell signalling to support invasion. The majority of clinical isolates produce fibronectin-binding proteins A and B (FnBPA and FnBPB) to interact with host integrin α5β1, a key component of focal adhesions. S. aureus binding of integ...
Source: European Journal of Cell Biology - September 8, 2023 Category: Cytology Authors: Stevens Robertin Dominik Brokatzky Dami án Lobato-Márquez Serge Mostowy Source Type: research
Regulation of integrin α5β1-mediated Staphylococcus aureus cellular invasion by the septin cytoskeleton
Eur J Cell Biol. 2023 Sep 3;102(4):151359. doi: 10.1016/j.ejcb.2023.151359. Online ahead of print.ABSTRACTStaphylococcus aureus, a Gram-positive bacterial pathogen, is an urgent health threat causing a wide range of clinical infections. Originally viewed as a strict extracellular pathogen, accumulating evidence has revealed S. aureus to be a facultative intracellular pathogen subverting host cell signalling to support invasion. The majority of clinical isolates produce fibronectin-binding proteins A and B (FnBPA and FnBPB) to interact with host integrin α5β1, a key component of focal adhesions. S. aureus binding of integ...
Source: European Journal of Cell Biology - September 8, 2023 Category: Cytology Authors: Stevens Robertin Dominik Brokatzky Dami án Lobato-Márquez Serge Mostowy Source Type: research
