Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
This article further discusses different approaches to specifically target cGAS/STING signaling in cancer cells to inhibit tumor growth and metastasis in conjunction with existing anticancer therapies.PMID:37423035 | DOI:10.1016/j.ejcb.2023.151338 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Vijay Kumar Caitlin Bauer John H Stewart Source Type: research
Clones of aging: When better fitness can be dangerous
Eur J Cell Biol. 2023 Jul 6;102(3):151340. doi: 10.1016/j.ejcb.2023.151340. Online ahead of print.ABSTRACTThe biological and clinical significance of aberrant clonal expansions in aged tissues is being intensely discussed. Evidence is accruing that these clones often result from the normal dynamics of cell turnover in our tissues. The aged tissue microenvironment is prone to favour the emergence of specific clones with higher fitness partly because of an overall decline in cell intrinsic regenerative potential of surrounding counterparts. Thus, expanding clones in aged tissues need not to be mechanistically associated with...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Fabio Marongiu Samuele Cheri Ezio Laconi Source Type: research
Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
Eur J Cell Biol. 2023 Jul 6;102(3):151339. doi: 10.1016/j.ejcb.2023.151339. Online ahead of print.ABSTRACTDespite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size and number. While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics in a methodological and quantitative manner. Herein we apply quantitative fluorescence microscopy to measure the size a...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Naava Naslavsky Steve Caplan Source Type: research
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
This article further discusses different approaches to specifically target cGAS/STING signaling in cancer cells to inhibit tumor growth and metastasis in conjunction with existing anticancer therapies.PMID:37423035 | DOI:10.1016/j.ejcb.2023.151338 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Vijay Kumar Caitlin Bauer John H Stewart Source Type: research
Clones of aging: When better fitness can be dangerous
Eur J Cell Biol. 2023 Jul 6;102(3):151340. doi: 10.1016/j.ejcb.2023.151340. Online ahead of print.ABSTRACTThe biological and clinical significance of aberrant clonal expansions in aged tissues is being intensely discussed. Evidence is accruing that these clones often result from the normal dynamics of cell turnover in our tissues. The aged tissue microenvironment is prone to favour the emergence of specific clones with higher fitness partly because of an overall decline in cell intrinsic regenerative potential of surrounding counterparts. Thus, expanding clones in aged tissues need not to be mechanistically associated with...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Fabio Marongiu Samuele Cheri Ezio Laconi Source Type: research
Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
Eur J Cell Biol. 2023 Jul 6;102(3):151339. doi: 10.1016/j.ejcb.2023.151339. Online ahead of print.ABSTRACTDespite their significance in receptor-mediated internalization and continued signal transduction in cells, early/sorting endosomes (EE/SE) remain incompletely characterized, with many outstanding questions that surround the dynamics of their size and number. While several studies have reported increases in EE/SE size and number resulting from endocytic events, few studies have addressed such dynamics in a methodological and quantitative manner. Herein we apply quantitative fluorescence microscopy to measure the size a...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Naava Naslavsky Steve Caplan Source Type: research
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
This article further discusses different approaches to specifically target cGAS/STING signaling in cancer cells to inhibit tumor growth and metastasis in conjunction with existing anticancer therapies.PMID:37423035 | DOI:10.1016/j.ejcb.2023.151338 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Vijay Kumar Caitlin Bauer John H Stewart Source Type: research
Clones of aging: When better fitness can be dangerous
Eur J Cell Biol. 2023 Jul 6;102(3):151340. doi: 10.1016/j.ejcb.2023.151340. Online ahead of print.ABSTRACTThe biological and clinical significance of aberrant clonal expansions in aged tissues is being intensely discussed. Evidence is accruing that these clones often result from the normal dynamics of cell turnover in our tissues. The aged tissue microenvironment is prone to favour the emergence of specific clones with higher fitness partly because of an overall decline in cell intrinsic regenerative potential of surrounding counterparts. Thus, expanding clones in aged tissues need not to be mechanistically associated with...
Source: European Journal of Cell Biology - July 9, 2023 Category: Cytology Authors: Fabio Marongiu Samuele Cheri Ezio Laconi Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
Eur J Cell Biol. 2023 Jun 26;102(3):151337. doi: 10.1016/j.ejcb.2023.151337. Online ahead of print.ABSTRACTDifferent studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the de...
Source: European Journal of Cell Biology - July 1, 2023 Category: Cytology Authors: Javad Alizadeh Simone C da Silva Rosa Xiaohui Weng Joadi Jacobs Shahrokh Lorzadeh Amir Ravandi Rui Vitorino Stevan Pecic Aleksandra Zivkovic Holger Stark Shahla Shojaei Saeid Ghavami Source Type: research
