Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate
Eur J Cell Biol. 2023 Aug 15;102(4):151354. doi: 10.1016/j.ejcb.2023.151354. Online ahead of print.ABSTRACTAlendronate (ALN) is a second-generation bisphosphonate widely used for osteoporosis and cancer-induced bone lesions. Many studies have confirmed a strong relationship between osteonecrosis of the jaws (ONJ) development and oral bisphosphonates, especially ALN, although the molecular mechanisms underlying this pathology have not yet been elucidated. The reduction in bone turnover and vascularization usually observed in ONJ are the result of ALN action on different cell types harboured in oral microenvironment, such as...
Source: European Journal of Cell Biology - August 21, 2023 Category: Cytology Authors: Anna Di Vito Emanuela Chiarella Jessica Sovereto Jessica Bria Ida Daniela Perrotta Alessandro Salatino Francesco Baudi Alessandro Sacco Alessandro Antonelli Flavia Biamonte Tullio Barni Amerigo Giudice Source Type: research
Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate
Eur J Cell Biol. 2023 Aug 15;102(4):151354. doi: 10.1016/j.ejcb.2023.151354. Online ahead of print.ABSTRACTAlendronate (ALN) is a second-generation bisphosphonate widely used for osteoporosis and cancer-induced bone lesions. Many studies have confirmed a strong relationship between osteonecrosis of the jaws (ONJ) development and oral bisphosphonates, especially ALN, although the molecular mechanisms underlying this pathology have not yet been elucidated. The reduction in bone turnover and vascularization usually observed in ONJ are the result of ALN action on different cell types harboured in oral microenvironment, such as...
Source: European Journal of Cell Biology - August 21, 2023 Category: Cytology Authors: Anna Di Vito Emanuela Chiarella Jessica Sovereto Jessica Bria Ida Daniela Perrotta Alessandro Salatino Francesco Baudi Alessandro Sacco Alessandro Antonelli Flavia Biamonte Tullio Barni Amerigo Giudice Source Type: research
Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate
Eur J Cell Biol. 2023 Aug 15;102(4):151354. doi: 10.1016/j.ejcb.2023.151354. Online ahead of print.ABSTRACTAlendronate (ALN) is a second-generation bisphosphonate widely used for osteoporosis and cancer-induced bone lesions. Many studies have confirmed a strong relationship between osteonecrosis of the jaws (ONJ) development and oral bisphosphonates, especially ALN, although the molecular mechanisms underlying this pathology have not yet been elucidated. The reduction in bone turnover and vascularization usually observed in ONJ are the result of ALN action on different cell types harboured in oral microenvironment, such as...
Source: European Journal of Cell Biology - August 21, 2023 Category: Cytology Authors: Anna Di Vito Emanuela Chiarella Jessica Sovereto Jessica Bria Ida Daniela Perrotta Alessandro Salatino Francesco Baudi Alessandro Sacco Alessandro Antonelli Flavia Biamonte Tullio Barni Amerigo Giudice Source Type: research
Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate
Eur J Cell Biol. 2023 Aug 15;102(4):151354. doi: 10.1016/j.ejcb.2023.151354. Online ahead of print.ABSTRACTAlendronate (ALN) is a second-generation bisphosphonate widely used for osteoporosis and cancer-induced bone lesions. Many studies have confirmed a strong relationship between osteonecrosis of the jaws (ONJ) development and oral bisphosphonates, especially ALN, although the molecular mechanisms underlying this pathology have not yet been elucidated. The reduction in bone turnover and vascularization usually observed in ONJ are the result of ALN action on different cell types harboured in oral microenvironment, such as...
Source: European Journal of Cell Biology - August 21, 2023 Category: Cytology Authors: Anna Di Vito Emanuela Chiarella Jessica Sovereto Jessica Bria Ida Daniela Perrotta Alessandro Salatino Francesco Baudi Alessandro Sacco Alessandro Antonelli Flavia Biamonte Tullio Barni Amerigo Giudice Source Type: research
Recent advances in plant cell biology
Eur J Cell Biol. 2023 Aug 2:151345. doi: 10.1016/j.ejcb.2023.151345. Online ahead of print.NO ABSTRACTPMID:37596137 | DOI:10.1016/j.ejcb.2023.151345 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - August 18, 2023 Category: Cytology Authors: B énédicte Desvoyes Crisanto Gutierrez Source Type: research
Recent advances in plant cell biology
Eur J Cell Biol. 2023 Aug 2:151345. doi: 10.1016/j.ejcb.2023.151345. Online ahead of print.NO ABSTRACTPMID:37596137 | DOI:10.1016/j.ejcb.2023.151345 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - August 18, 2023 Category: Cytology Authors: B énédicte Desvoyes Crisanto Gutierrez Source Type: research
Recent advances in plant cell biology
Eur J Cell Biol. 2023 Aug 2:151345. doi: 10.1016/j.ejcb.2023.151345. Online ahead of print.NO ABSTRACTPMID:37596137 | DOI:10.1016/j.ejcb.2023.151345 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - August 18, 2023 Category: Cytology Authors: B énédicte Desvoyes Crisanto Gutierrez Source Type: research
Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H < sub > 2 < /sub > O < sub > 2 < /sub > and iron
Eur J Cell Biol. 2023 Aug 3;102(4):151346. doi: 10.1016/j.ejcb.2023.151346. Online ahead of print.ABSTRACTCold atmospheric plasmas and plasma-treated solutions (PTSs) have emerged as promising approaches in cancer treatment because of their tumor-selective actions. While oxidative stress is critical for their effects, the precise mechanisms, including chemical mediators, remain obscure. Previously, we reported that air plasma-activated medium (APAM) exhibited tumor-selective anticancer activity. The fragmentation of mitochondria and their asymmetrical assembly around the peripheral regions of the damaged nucleus, namely, m...
Source: European Journal of Cell Biology - August 12, 2023 Category: Cytology Authors: Manami Suzuki-Karasaki Yushi Ochiai Shizuka Innami Hiroshi Okajima Miki Suzuki-Karasaki Hideki Nakayama Yoshihiro Suzuki-Karasaki Source Type: research
Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H < sub > 2 < /sub > O < sub > 2 < /sub > and iron
Eur J Cell Biol. 2023 Aug 3;102(4):151346. doi: 10.1016/j.ejcb.2023.151346. Online ahead of print.ABSTRACTCold atmospheric plasmas and plasma-treated solutions (PTSs) have emerged as promising approaches in cancer treatment because of their tumor-selective actions. While oxidative stress is critical for their effects, the precise mechanisms, including chemical mediators, remain obscure. Previously, we reported that air plasma-activated medium (APAM) exhibited tumor-selective anticancer activity. The fragmentation of mitochondria and their asymmetrical assembly around the peripheral regions of the damaged nucleus, namely, m...
Source: European Journal of Cell Biology - August 12, 2023 Category: Cytology Authors: Manami Suzuki-Karasaki Yushi Ochiai Shizuka Innami Hiroshi Okajima Miki Suzuki-Karasaki Hideki Nakayama Yoshihiro Suzuki-Karasaki Source Type: research
Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H < sub > 2 < /sub > O < sub > 2 < /sub > and iron
Eur J Cell Biol. 2023 Aug 3;102(4):151346. doi: 10.1016/j.ejcb.2023.151346. Online ahead of print.ABSTRACTCold atmospheric plasmas and plasma-treated solutions (PTSs) have emerged as promising approaches in cancer treatment because of their tumor-selective actions. While oxidative stress is critical for their effects, the precise mechanisms, including chemical mediators, remain obscure. Previously, we reported that air plasma-activated medium (APAM) exhibited tumor-selective anticancer activity. The fragmentation of mitochondria and their asymmetrical assembly around the peripheral regions of the damaged nucleus, namely, m...
Source: European Journal of Cell Biology - August 12, 2023 Category: Cytology Authors: Manami Suzuki-Karasaki Yushi Ochiai Shizuka Innami Hiroshi Okajima Miki Suzuki-Karasaki Hideki Nakayama Yoshihiro Suzuki-Karasaki Source Type: research
Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H < sub > 2 < /sub > O < sub > 2 < /sub > and iron
Eur J Cell Biol. 2023 Aug 3;102(4):151346. doi: 10.1016/j.ejcb.2023.151346. Online ahead of print.ABSTRACTCold atmospheric plasmas and plasma-treated solutions (PTSs) have emerged as promising approaches in cancer treatment because of their tumor-selective actions. While oxidative stress is critical for their effects, the precise mechanisms, including chemical mediators, remain obscure. Previously, we reported that air plasma-activated medium (APAM) exhibited tumor-selective anticancer activity. The fragmentation of mitochondria and their asymmetrical assembly around the peripheral regions of the damaged nucleus, namely, m...
Source: European Journal of Cell Biology - August 12, 2023 Category: Cytology Authors: Manami Suzuki-Karasaki Yushi Ochiai Shizuka Innami Hiroshi Okajima Miki Suzuki-Karasaki Hideki Nakayama Yoshihiro Suzuki-Karasaki Source Type: research
Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H < sub > 2 < /sub > O < sub > 2 < /sub > and iron
Eur J Cell Biol. 2023 Aug 3;102(4):151346. doi: 10.1016/j.ejcb.2023.151346. Online ahead of print.ABSTRACTCold atmospheric plasmas and plasma-treated solutions (PTSs) have emerged as promising approaches in cancer treatment because of their tumor-selective actions. While oxidative stress is critical for their effects, the precise mechanisms, including chemical mediators, remain obscure. Previously, we reported that air plasma-activated medium (APAM) exhibited tumor-selective anticancer activity. The fragmentation of mitochondria and their asymmetrical assembly around the peripheral regions of the damaged nucleus, namely, m...
Source: European Journal of Cell Biology - August 12, 2023 Category: Cytology Authors: Manami Suzuki-Karasaki Yushi Ochiai Shizuka Innami Hiroshi Okajima Miki Suzuki-Karasaki Hideki Nakayama Yoshihiro Suzuki-Karasaki Source Type: research
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis
In this study, a yeast two-hybrid screen revealed a novel binding partner for USP10, the formin, DAAM1. We found that DAAM1 binds to and inhibits USP10's DUB activity through the FH2 domain of DAAM1 independent of its actin functions. The USP10/DAAM1 interaction was also supported by proximity ligation assay (PLA) in primary human corneal fibroblasts. Treatment with TGFβ1 significantly increased USP10 and DAAM1 protein expression, PLA signal, and co-localization to actin stress fibers. DAAM1 siRNA knockdown significantly reduced co-precipitation of USP10 and DAAM1 on purified actin stress fibers, and β1- and β5-integrin...
Source: European Journal of Cell Biology - August 10, 2023 Category: Cytology Authors: Andrew T Phillips Edward F Boumil Arunkumar Venkatesan Christine Tilstra-Smith Nileyma Castro Barry E Knox Jessica L Henty-Ridilla Audrey M Bernstein Source Type: research
Three-dimensional chromatin architecture in plants - General features and novelties
We present an overview on plant 3D genome organizational features that resemble those in animals and highlight facets that have only been observed in plants to date.PMID:37562220 | DOI:10.1016/j.ejcb.2023.151344 (Source: European Journal of Cell Biology)
Source: European Journal of Cell Biology - August 10, 2023 Category: Cytology Authors: Edouard Tourdot Stefan Grob Source Type: research
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis
In this study, a yeast two-hybrid screen revealed a novel binding partner for USP10, the formin, DAAM1. We found that DAAM1 binds to and inhibits USP10's DUB activity through the FH2 domain of DAAM1 independent of its actin functions. The USP10/DAAM1 interaction was also supported by proximity ligation assay (PLA) in primary human corneal fibroblasts. Treatment with TGFβ1 significantly increased USP10 and DAAM1 protein expression, PLA signal, and co-localization to actin stress fibers. DAAM1 siRNA knockdown significantly reduced co-precipitation of USP10 and DAAM1 on purified actin stress fibers, and β1- and β5-integrin...
Source: European Journal of Cell Biology - August 10, 2023 Category: Cytology Authors: Andrew T Phillips Edward F Boumil Arunkumar Venkatesan Christine Tilstra-Smith Nileyma Castro Barry E Knox Jessica L Henty-Ridilla Audrey M Bernstein Source Type: research
