Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis
In this study, we employed Illumina-based RNA sequencing (RNAseq) to profile the genome-wide transcriptome of Bulinus globosus, one of the most important intermediate hosts for S. haematobium in Africa. A total of 179,221 transcripts (N50 = 1235) were assembled and the benchmarking universal single-copy orthologs (BUSCO) was estimated to be 97.7%. The analysis revealed a substantial number of transcripts encoding evolutionarily conserved immune-related proteins, particularly C-type lectin (CLECT) domain-containing proteins (n = 316), Toll/Interleukin 1-receptor (TIR)-containing proteins (n = 75), and fibrinogen related dom...
Source: Developmental and Comparative Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Lijing Bu Mohamed R Habib Lijun Lu Martin W Mutuku Eric S Loker Si-Ming Zhang Source Type: research

Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family
In this study, we aimed to analyze the regulation of diel oscillations in the expression of TLR genes in Japanese medaka (Oryzias latipes). The expression analysis revealed diel expression patterns of tlr1, tlr5m, tlr21, and clock genes (bmal1 and clock1) under a 12 h light:12 h dark cycle. The clock gene response element (E-box) was identified in the transcriptional regulatory regions of tlr1, tlr5m, and tlr21. Moreover, overexpressed bmal1 and clock1 enhanced expression levels of tlr1, tlr5m, and tlr21 in medaka embryo (OLHdrR-e3) cells. The expression of tlr1, tlr5m, and tlr21 was significantly decreased in OLHdrR-e3 af...
Source: Developmental and Comparative Immunology - February 10, 2024 Category: Allergy & Immunology Authors: Takahiko Hata Hidetoshi Shimawaki Suzuka Setoguchi Natsuki Morimoto Jun-Ichi Hikima Masahiro Sakai Tomoya Kono Source Type: research

A family of olfactory receptors uniquely expanded in marsupial and monotreme genomes are expressed by a T cell subset also unique to marsupials and monotremes
Dev Comp Immunol. 2024 Feb 8;154:105149. doi: 10.1016/j.dci.2024.105149. Online ahead of print.ABSTRACTOlfactory receptors (OR), expressed on olfactory neurons, mediate the sense of smell. Recently, OR have also been shown to be expressed in non-olfactory tissues, including cells of the immune system. An analysis of single-cell transcriptomes of splenocytes of the grey short-tailed opossum (Monodelphis domestica) found OR are expressed on a subset of T cells, the γμ T cells, that are unique to marsupials and monotremes. A majority of opossum γμ T cells transcriptomes contain OR family 14 transcripts, specifically, from...
Source: Developmental and Comparative Immunology - February 10, 2024 Category: Allergy & Immunology Authors: Jordan M Sampson Kimberly A Morrissey Daniel C Douek Robert D Miller Source Type: research

A family of olfactory receptors uniquely expanded in marsupial and monotreme genomes are expressed by a T cell subset also unique to marsupials and monotremes
Dev Comp Immunol. 2024 Feb 8:105149. doi: 10.1016/j.dci.2024.105149. Online ahead of print.ABSTRACTOlfactory receptors (OR), expressed on olfactory neurons, mediate the sense of smell. Recently, OR have also been shown to be expressed in non-olfactory tissues, including cells of the immune system. An analysis of single-cell transcriptomes of splenocytes of the grey short-tailed opossum (Monodelphis domestica) found OR are expressed on a subset of T cells, the γμ T cells, that are unique to marsupials and monotremes. A majority of opossum γμ T cells transcriptomes contain OR family 14 transcripts, specifically, from the...
Source: Developmental and Comparative Immunology - February 10, 2024 Category: Allergy & Immunology Authors: Jordan M Sampson Kimberly A Morrissey Daniel C Douek Robert D Miller Source Type: research

Cleavage of gasdermin by apoptotic caspases triggers pyroptosis restricting bacterial colonization in Hydra
In conclusion, these results suggest that GSDME-dependent pyroptosis may be an ancient and conserved host defense mechanism, which may contribute to better understanding on the origin and evolution of GSDMs.PMID:38325499 | DOI:10.1016/j.dci.2024.105139 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - February 7, 2024 Category: Allergy & Immunology Authors: Shuxin Li Xiaoyang Lu Xiuqing Lin Yuanxing Zhang Qin Liu Shouwen Chen Source Type: research

Caenorhabditis elegans immune responses to microsporidia and viruses
Dev Comp Immunol. 2024 Feb 6;154:105148. doi: 10.1016/j.dci.2024.105148. Online ahead of print.ABSTRACTThe model organism Caenorhabditis elegans is susceptible to infection by obligate intracellular pathogens, specifically microsporidia and viruses. These intracellular pathogens infect intestinal cells, or, for some microsporidia, epidermal cells. Strikingly, intestinal cell infections by viruses or microsporidia trigger a common transcriptional response, activated in part by the ZIP-1 transcription factor. Among the strongest activated genes in this response are ubiquitin-pathway members and members of the pals family, an...
Source: Developmental and Comparative Immunology - February 7, 2024 Category: Allergy & Immunology Authors: Rub én González Marie-Anne F élix Source Type: research

Natural selection directing molecular evolution in vertebrate viral sensors
Dev Comp Immunol. 2024 Feb 5:105147. doi: 10.1016/j.dci.2024.105147. Online ahead of print.ABSTRACTDiseases caused by pathogens contribute to molecular adaptations in host immunity. Variety of viral pathogens challenging animal immunity can drive positive selection diversifying receptors recognising the infections. However, whether distinct virus sensing systems differ across animals in their evolutionary modes remains unclear. Our review provides a comparative overview of natural selection shaping molecular evolution in vertebrate viral-binding pattern recognition receptors (PRRs). Despite prevailing negative selection ar...
Source: Developmental and Comparative Immunology - February 7, 2024 Category: Allergy & Immunology Authors: Balraj Melepat Tao Li Michal Vinkler Source Type: research

Characterization of the antibacterial and opsonic functions of the antimicrobial peptide LvCrustinVI from Litopenaeus vannamei
In conclusion, LvCrustinVI played important roles as antimicrobial peptide and opsonin in the innate immune defense of L. vannamei. The study enriched our understanding of the functional activity of Crustin and provides an important basis for the development and utilization of antimicrobial peptides.PMID:38316231 | DOI:10.1016/j.dci.2024.105146 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Jie Hu Shihao Li Miao Miao Fuhua Li Source Type: research

The effects of four paralogous piscidin antimicrobial peptides on the chemotaxis, macrophage respiratory burst, phagocytosis and expression of immune-related genes in orange-spotted grouper (Epinephelus coicodes)
This study makes a significant contribution to the field of fish AMPs immunology by elucidating the novel mechanisms through which members of the piscidin family exert their immunomodulatory effects. Moreover, it provides valuable insights for further exploration of fish immunomodulating agents.PMID:38316232 | DOI:10.1016/j.dci.2024.105144 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Xiazi Huang Wei Mao Yonghao Yi Yubin Lu Feihong Liu Li Deng Source Type: research

Effects on viral suppression and the early-immune expression of ribavirin against spring viremia of carp virus in vitro
Dev Comp Immunol. 2024 Feb 3;154:105145. doi: 10.1016/j.dci.2024.105145. Online ahead of print.ABSTRACTSpring viremia of carp virus (SVCV) is a globally distributed virus that causes severe clinical symptoms and high mortality in fish belonging to the families Cyprinidae and Siluridae. To protect the host against viral infection, understanding the relatedness between viral susceptibility and antiviral mechanisms must be crucial. Thus, we evaluated the viral suppression efficacy of ribavirin by measuring the transcription levels of viral and immune genes in vitro. The results showed that following ribavirin treatment after ...
Source: Developmental and Comparative Immunology - February 5, 2024 Category: Allergy & Immunology Authors: Eun Jin Baek Ye Jin Jeong Guk Hyun Kim Min Jae Kim Kwang Il Kim Source Type: research

SfMBP: A novel microbial binding protein and pattern recognition receptor in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
In this study, we identified a novel microbial binding protein, SfMBP, in S. frugiperda. However, the specific role of SfMBP in the immune response of S. frugiperda remains elusive. Encoded by the LOC118269163 gene, SfMBP shows significant induction in S. frugiperda larvae infected with the entomopathogen Beauveria bassiana. Consisting of 115 amino acids with a signal peptide, an N-terminal flexible region and a C-terminal β-sheet, SfMBP lacks any known functional domains. It is expressed predominantly during early larval stages and in the larval epidermis. Notably, SfMBP is significantly induced in larvae infected with b...
Source: Developmental and Comparative Immunology - February 3, 2024 Category: Allergy & Immunology Authors: Bang-Xian Zhang Fang-Fang Liu Feng Liu Wen-Xuan Qi Yan-Qin Si Hai-Yan Ren Xiang-Jun Rao Source Type: research

Klebsiella aerogenes ingestion elicits behavioral changes and innate immunity in the host, Caenorhabditis elegans
Dev Comp Immunol. 2024 Jan 27;154:105138. doi: 10.1016/j.dci.2024.105138. Online ahead of print.ABSTRACTKlebsiella aerogenes (previously known as Enterobacter aerogenes) is a common opportunistic pathogen that infect the respiratory tract and central nervous system. However, how it interferes the host regulatory mechanism has not been previously described. When C. elegans were exposed to K. aerogenes, they exhibited a shorter lifespan compared to those fed with E. coli OP50. The time required for 50 % of L4 hermaphrodite nematodes to die when exposed to K. aerogenes was approximately 9 days, whereas it was about 18 days wh...
Source: Developmental and Comparative Immunology - January 29, 2024 Category: Allergy & Immunology Authors: Thirumugam Gowripriya Radhakrishnan Yashwanth Bhaskar James Prabhanand Ramamurthi Suresh Krishnaswamy Balamurugan Source Type: research

Aeromonas veronii tolC modulates its virulence and the immune response of freshwater pearl mussels, Hyriopsis cumingii
Dev Comp Immunol. 2024 Apr;153:105137. doi: 10.1016/j.dci.2024.105137. Epub 2024 Jan 14.ABSTRACTAeromonas veronii is an opportunistic pathogen that causes diseases in aquatic animals, but its key virulence factors remain unclear. We screened the gene tolC with significantly different expression levels in the two isolates, A. veronii GL2 (higher virulence) and A. veronii FO1 (lower virulence). Therefore, we constructed mutant strain ΔtolC and analyzed its immunological properties. ΔtolC exhibited the reduced ability of biofilms formation, inhibited envelope stress response mediated by several antibiotics except cefuroxime...
Source: Developmental and Comparative Immunology - January 15, 2024 Category: Allergy & Immunology Authors: Sichun Zheng Xiaoqi Tang Qinglin Yang Xicheng Zhou Yanhong Li Zhengli Wu Source Type: research

In Memoriam: Bradley Gregg Magor, 1960-2023
Dev Comp Immunol. 2024 Jan 12:105133. doi: 10.1016/j.dci.2024.105133. Online ahead of print.NO ABSTRACTPMID:38218675 | DOI:10.1016/j.dci.2024.105133 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - January 13, 2024 Category: Allergy & Immunology Source Type: research