Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The interactions between CpG oligodeoxynucleotides and Toll-like receptors in Pacific white shrimp Litopenaeus vannamei
Dev Comp Immunol. 2024 Feb 27:105157. doi: 10.1016/j.dci.2024.105157. Online ahead of print.ABSTRACTCpG oligodeoxynucleotides (ODNs), as a novel type of adjuvant with immunomodulatory effects, are recognized by Toll-like receptors (TLRs) in Litopenaeus vannamei. In the present study, eleven LvTLRs-pCMV recombinants (rLvTLRs) were constructed to investigate the relationships between various CpG ODNs and different LvTLRs in human embryonic kidney 293T (HEK293T) cells, which was further confirmed by bio-layer interferometry (BLI) technique. The results of dual luciferase reporter assay showed that every LvTLR could activate m...
Source: Developmental and Comparative Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Xuerui Gong Feng Hu Jingjie Hu Zhenmin Bao Mengqiang Wang Source Type: research

The cytokine genes of Oncorhynchus masou formosanus include a defective interleukin-4/13A gene
Dev Comp Immunol. 2024 Feb 27:105156. doi: 10.1016/j.dci.2024.105156. Online ahead of print.ABSTRACTOncorhynchus masou formosanus (Formosa landlocked salmon) is a critically endangered salmonid fish endemic to Taiwan. To begin to understand how its drastic change in lifestyle from anadromous to exclusively river-dwelling is reflected in its immune genes, we characterized the genes encoding six cytokines (IL-2A, IL-2B, IL-4/13A, IL-4/13B1, IL-4/13B2, and IL-17A/F2a) important for T cell responses as no genomic data is available for this fish. Interestingly, all genes appeared homozygous indicative of a genetic bottleneck. T...
Source: Developmental and Comparative Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ying-Hsuan Yen De Yu Zheng Shu Yuan Yang Jin-Chywan Gwo Sebastian D Fugmann Source Type: research

Characterization of extracellular trap production and release by equine neutrophils in response to different stimuli
This study explores Neutrophil Extracellular Trap (NET) formation in equine neutrophils, which is crucial for eliminating infections and is implicated in various equine inflammatory diseases. We investigated the molecular pathways involved in NET release by equine neutrophils in response to stimuli. We use PMA, A23187, LPS, PAF, OZ, and cytokines, observing NET release in response to PMA, PAF, and A23187. In contrast, LPS, OZ, and the cytokines tested did not induce DNA release or did not consistently induce citrullination of histone 4. Peptidyl-arginine deiminase inhibition completely halted NET release, while NADPH oxida...
Source: Developmental and Comparative Immunology - February 29, 2024 Category: Allergy & Immunology Authors: John Quiroga Bayron Cortes Jos é Sarmiento Gabriel Mor án Claudio Henr íquez Source Type: research

Interferon regulatory factors inhibit TiLV replication by activating interferon-a3 in tilapia (Oreochromis niloticus)
Dev Comp Immunol. 2024 Feb 24:105152. doi: 10.1016/j.dci.2024.105152. Online ahead of print.ABSTRACTTilapia lake virus (TiLV) is an emerging virus that seriously threatens the tilapia industries worldwide. Interferon regulatory factors (IRFs), which are the crucial mediators regulating the response of interferon (IFN) to combat invading viruses, have not yet been reported in tilapia during TiLV infection. Here, six IRF (IRF1, IRF2, IRF4, IRF7, IRF8, and IRF9) homologs from tilapia were characterized and analyzed. These IRFs typically shared the conserved domains and phylogenetic relationship with IRF homologs of other spec...
Source: Developmental and Comparative Immunology - February 26, 2024 Category: Allergy & Immunology Authors: Zishan Ke Jing Wen Yingying Wang Bo Li Siyu Wu Defeng Zhang Xubing Mo Yingying Li Yan Ren Jiyuan Yin Cunbin Shi Shucheng Zheng Qing Wang Source Type: research

Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis
In this study, we employed Illumina-based RNA sequencing (RNAseq) to profile the genome-wide transcriptome of Bulinus globosus, one of the most important intermediate hosts for S. haematobium in Africa. A total of 179,221 transcripts (N50 = 1,235) were assembled and the benchmarking universal single-copy orthologs (BUSCO) was estimated to be 97.7%. The analysis revealed a substantial number of transcripts encoding evolutionarily conserved immune-related proteins, particularly C-type lectin (CLECT) domain-containing proteins (n = 316), Toll/Interleukin 1-receptor (TIR)-containing proteins (n = 75), and fibrinogen related do...
Source: Developmental and Comparative Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Lijing Bu Mohamed R Habib Lijun Lu Martin W Mutuku Eric S Loker Si-Ming Zhang Source Type: research

Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis
In this study, we employed Illumina-based RNA sequencing (RNAseq) to profile the genome-wide transcriptome of Bulinus globosus, one of the most important intermediate hosts for S. haematobium in Africa. A total of 179,221 transcripts (N50 = 1235) were assembled and the benchmarking universal single-copy orthologs (BUSCO) was estimated to be 97.7%. The analysis revealed a substantial number of transcripts encoding evolutionarily conserved immune-related proteins, particularly C-type lectin (CLECT) domain-containing proteins (n = 316), Toll/Interleukin 1-receptor (TIR)-containing proteins (n = 75), and fibrinogen related dom...
Source: Developmental and Comparative Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Lijing Bu Mohamed R Habib Lijun Lu Martin W Mutuku Eric S Loker Si-Ming Zhang Source Type: research