Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Peripheral inflammation-induced changes in songbird brain gene expression: 3' mRNA transcriptomic approach
Dev Comp Immunol. 2023 Nov 25:105106. doi: 10.1016/j.dci.2023.105106. Online ahead of print.ABSTRACTSpecies-specific neural inflammation can be induced by profound immune signalling from periphery to brain. Recent advances in transcriptomics offer cost-effective approaches to study this regulation. In a population of captive zebra finch (Taeniopygia guttata), we compare the differential gene expression patterns in lipopolysaccharide (LPS)-triggered peripheral inflammation revealed by RNA-seq and QuantSeq. The RNA-seq approach identified more differentially expressed genes but failed to detect any inflammatory markers. In c...
Source: Developmental and Comparative Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Nithya Kuttiyarthu Veetil Haniel Cedraz de Oliveira Mercedes Gom éz Samblas Daniel Div ín Balraj Melepat Eleni Voukali Zuzana Świderská Tereza Krajzingrov á Martin T ěšický Ferris Jung Vladim ír Beneš Ole Madsen Michal Vinkler Source Type: research

The identification of regulatory ceRNA network involved in Drosophila Toll immune responses
This study provides evidence of a ceRNA regulatory network in Drosophila Toll immune responses and offers novel insights into understanding the regulatory networks involved in the innate immunity of other animals.PMID:38013113 | DOI:10.1016/j.dci.2023.105105 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Yu Huang Yujia Pang Yina Xu Li Liu Hongjian Zhou Source Type: research

Comprehensive analysis of circRNA-miRNA-mRNA networks in the kidney of snakehead (Channa argus) response to Nocardia seriolae challenge
Dev Comp Immunol. 2023 Nov 23:105099. doi: 10.1016/j.dci.2023.105099. Online ahead of print.ABSTRACTThe non-coding RNAs (ncRNAs) play vital roles in regulating the expression levels of genes that control essential biological functions, including immune response to bacterial infections in teleost. To dissect the roles of ncRNAs in the Channa argus (snakehead), a systematic analysis of the expression profiles of circRNA, miRNA and mRNA, as well as competing endogenous RNAs (ceRNA) regulatory networks in the kidney of snakehead following Nocardia seriolae infection were performed in the present study. A total of 111 different...
Source: Developmental and Comparative Immunology - November 25, 2023 Category: Allergy & Immunology Authors: Xiaoyan Zhang Yanliang Jiang Haohui Yu Ningning Wang Xiantong Liu Min Cao Chao Li Source Type: research

Molecular cloning and functional characterization of pigeon IKK ε
In this study, we successfully cloned pigeon IKKε (piIKKε) from pigeon embryo fibroblasts (PEFs) for the first time. This gene encodes 722 amino acids and shares high amino acid similarity with its duck and goose counterparts. piIKKε showed a diffuse cytoplasmic distribution and broad expression in all tissues examined. Overexpression of piIKKε in PEFs significantly activated the IFN-β promoter, with both the kinase and CC domains of piIKKε playing key roles in initiating IFN-β expression. Knockdown of piIKKε using small interfering RNA significantly reduced the levels of IFN-β induced by NDV, AIV, poly (I:C), or ...
Source: Developmental and Comparative Immunology - November 24, 2023 Category: Allergy & Immunology Authors: Peng Zhou Aixin Liu Dong Chen Wanrong Wu Qingxiang Zhang Huanchun Chen Hongbo Zhou Rui Luo Source Type: research

The Lrp transcriptional factor of an entomopathogenic bacterium, Xenorhabdus hominickii, activates non-ribosomal peptide synthetases to suppress insect immunity
This study investigated the bacterial genes regulated by Lrp and the subsequent production of secondary metabolites in Xenorhabdus hominickii. Lrp expression occurred at the early infection stage of the bacteria in a target insect, Spodoptera exigua. A preliminary in silico screening indicated that 3.7% genes among 4075 predicted genes encoded in X. hominickii had the Lrp-response element on their promoters, including two non-ribosomal peptide synthetases (NRPSs). Eight NRPS (NRPS1-NRPS8) genes were predicted in the bacterial genome, in which six NRPS (NRPS3-NRPS8) expressions were positively correlated with Lrp expression...
Source: Developmental and Comparative Immunology - November 24, 2023 Category: Allergy & Immunology Authors: Gahyeon Jin Il-Hwan Kim Yonggyun Kim Source Type: research

Identification and expression analysis of Oxfibrillin gene involved in the regeneration process of Ophryotrocha xiamen (Annelida, Dorcilleidae)
Dev Comp Immunol. 2023 Nov 21:105102. doi: 10.1016/j.dci.2023.105102. Online ahead of print.ABSTRACTRegeneration of lost body parts is a widespread phenomenon across annelids. However, the molecular inducers of the cell sources for this reparative morphogenesis have not been identified. We have identified a regeneration-related gene Oxfibrillin from the transcriptome analysis of a polychaeta, Ophryotrocha xiamen, which is found to be a well-suited model to study the mechanisms of regeneration. Fibrillins are large glycoproteins that assemble to form the microfibrils and regulate growth factors or other transfer processes. ...
Source: Developmental and Comparative Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ruanni Chen Yunying Cheng Yuting Zhang Jianming Chen Source Type: research

The goldfish primary kidney macrophage system
Dev Comp Immunol. 2023 Nov 15:105100. doi: 10.1016/j.dci.2023.105100. Online ahead of print.ABSTRACTMiodrag (Mike) Belosevic and collaborators profoundly influenced the development of primary kidney macrophage culturing system (PKM) to study fish immunology in various aspects of comparative immunology. Their application of using PKM model, opened a new path for studying the development of macrophages, regulation of hematopoiesis, and cell specific response against various pathogens. By measuring histopathological and immunological outcomes, the biological implications of a variety of cytokines and signal transduction molec...
Source: Developmental and Comparative Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Xionglin Li Xinyuan Yue Jiasong Xie Source Type: research