Developmental and Comparative Immunology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Immuno-molecular profile for Biomphalaria glabrata/Schistosoma mansoni interaction
Dev Comp Immunol. 2023 Oct 16:105083. doi: 10.1016/j.dci.2023.105083. Online ahead of print.ABSTRACTThe complex innate immune defense of Biomphalaria glabrata, the intermediate host of Schistosoma mansoni, governs the successful development of the intramolluscan stages of the parasite. The interaction between the snail and the parasite involves a complex immune molecular crosstalk between several parasite antigens and the snail immune recognition receptors, evoking different signals and effector molecules. This work seeks to discuss the immune-related molecules that influence compatibility in Biomphalaria glabrata/Schistos...
Source: Developmental and Comparative Immunology - October 18, 2023 Category: Allergy & Immunology Authors: Iman Fathy Abou-El-Naga Nermine Mogahed Fawzy Hussein Mogahed Source Type: research
Monitoring platelet function in marine mammals: Intracellular Ca < sup > 2+ < /sup > mobilization as a biomarker of platelet activation
Dev Comp Immunol. 2023 Oct 14:105080. doi: 10.1016/j.dci.2023.105080. Online ahead of print.ABSTRACTPlatelet functionality plays a crucial role in marine mammals. Alterations in platelet function can result from stress, pathologies, or exposure to xenobiotics, among others. The early detection of platelet function abnormalities is essential in these species to prevent advanced pathology and mitigate potential risks. Our main objective was to establish a range of physiological values of platelet function in bottlenose dolphins (Tursiops truncatus), beluga whales (Delphinapterus leucas), sea lions (Otaria flavescens) and wal...
Source: Developmental and Comparative Immunology - October 16, 2023 Category: Allergy & Immunology Authors: Mar Felipo-Benavent Jos é-Enrique O'Connor Teresa Álvaro-Álvarez M ónica Valls-Torres Carlos Rojo Daniel Garc ía-Párraga Alicia Mart ínez-Romero Consuelo Rubio-Guerri Source Type: research
Monitoring platelet function in marine mammals: Intracellular Ca < sup > 2+ < /sup > mobilization as a biomarker of platelet activation
Dev Comp Immunol. 2023 Oct 14:105080. doi: 10.1016/j.dci.2023.105080. Online ahead of print.ABSTRACTPlatelet functionality plays a crucial role in marine mammals. Alterations in platelet function can result from stress, pathologies, or exposure to xenobiotics, among others. The early detection of platelet function abnormalities is essential in these species to prevent advanced pathology and mitigate potential risks. Our main objective was to establish a range of physiological values of platelet function in bottlenose dolphins (Tursiops truncatus), beluga whales (Delphinapterus leucas), sea lions (Otaria flavescens) and wal...
Source: Developmental and Comparative Immunology - October 16, 2023 Category: Allergy & Immunology Authors: Mar Felipo-Benavent Jos é-Enrique O'Connor Teresa Álvaro-Álvarez M ónica Valls-Torres Carlos Rojo Daniel Garc ía-Párraga Alicia Mart ínez-Romero Consuelo Rubio-Guerri Source Type: research
Monitoring platelet function in marine mammals: Intracellular Ca < sup > 2+ < /sup > mobilization as a biomarker of platelet activation
Dev Comp Immunol. 2023 Oct 14:105080. doi: 10.1016/j.dci.2023.105080. Online ahead of print.ABSTRACTPlatelet functionality plays a crucial role in marine mammals. Alterations in platelet function can result from stress, pathologies, or exposure to xenobiotics, among others. The early detection of platelet function abnormalities is essential in these species to prevent advanced pathology and mitigate potential risks. Our main objective was to establish a range of physiological values of platelet function in bottlenose dolphins (Tursiops truncatus), beluga whales (Delphinapterus leucas), sea lions (Otaria flavescens) and wal...
Source: Developmental and Comparative Immunology - October 16, 2023 Category: Allergy & Immunology Authors: Mar Felipo-Benavent Jos é-Enrique O'Connor Teresa Álvaro-Álvarez M ónica Valls-Torres Carlos Rojo Daniel Garc ía-Párraga Alicia Mart ínez-Romero Consuelo Rubio-Guerri Source Type: research
Effects of dietary Vibrio sp. 33 on growth, innate immunity, gut microbiota profile and disease resistance against Vibrio splendidus of juvenile sea cucumber Apostichopus japonicus
Dev Comp Immunol. 2023 Oct 13:105081. doi: 10.1016/j.dci.2023.105081. Online ahead of print.ABSTRACTTo investigate the ability of Vibrio sp. V33 supplementation on the growth performance, innate immunity, intestinal microbiota, and disease resistance of the juvenile sea cucumber Apostichopus japonicus, a feeding experiment was conducted. Our results revealed that dietary Vibrio sp. V33 could significantly enhanced sea cucumber growth rate, and the immune parameters including total coelomocytes counts (TCC), phagocytosis, respiratory burst, immune-related enzyme activities (acid phosphatase, alkaline phosphatase, superoxide...
Source: Developmental and Comparative Immunology - October 15, 2023 Category: Allergy & Immunology Authors: Tianyu Lu Chengyang Wang Ming Guo Chenghua Li Yina Shao Source Type: research
Recent selection created distinctive variability patters on MHC class II loci in three dolphin species from the Mediterranean Sea
Dev Comp Immunol. 2023 Oct 11:105079. doi: 10.1016/j.dci.2023.105079. Online ahead of print.ABSTRACTThe major histocompatibility complex (MHC) includes highly polymorphic genes involved in antigen presentation, which is crucial for adaptive immune response. They represent fitness related genetic markers particularly informative for populations exposed to environmental challenges. Here we analyse the diversity and evolutionary traits of MHC class II DQA and DQB genes in the dolphins Stenella coeruleoalba and Grampus griseus from the Mediterranean Sea. We found substantial nucleotide and functional diversity, as well as stro...
Source: Developmental and Comparative Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Haidi Arbanasi ć Luis Medrano-Gonz ález Tomica Hrenar Ana Mikeli ć Tomislav Gomer čić Ida Svetli čić Željko Pavlinec Martina Đuras Ana Galov Source Type: research
Recent selection created distinctive variability patters on MHC class II loci in three dolphin species from the Mediterranean Sea
Dev Comp Immunol. 2023 Oct 11:105079. doi: 10.1016/j.dci.2023.105079. Online ahead of print.ABSTRACTThe major histocompatibility complex (MHC) includes highly polymorphic genes involved in antigen presentation, which is crucial for adaptive immune response. They represent fitness related genetic markers particularly informative for populations exposed to environmental challenges. Here we analyse the diversity and evolutionary traits of MHC class II DQA and DQB genes in the dolphins Stenella coeruleoalba and Grampus griseus from the Mediterranean Sea. We found substantial nucleotide and functional diversity, as well as stro...
Source: Developmental and Comparative Immunology - October 13, 2023 Category: Allergy & Immunology Authors: Haidi Arbanasi ć Luis Medrano-Gonz ález Tomica Hrenar Ana Mikeli ć Tomislav Gomer čić Ida Svetli čić Željko Pavlinec Martina Đuras Ana Galov Source Type: research
Involvement of transcriptional co-activator p300 in upregulated expression of HSP70 by aquareovirus non-structural protein NS31
In this study, we further found that either the N- or C-terminal domain of GCRV NS31 is responsible for enhancing fish HSP70 promoter transcription, and recombinant NS31 protein purified from baculovirus expression system seems to not directly bind HSP70 basic promoter in vitro by an electrophoretic mobility shift assay. However, the transcriptional co-activator p300 was identified as a potential interacting partner for NS31 by pull-down assay. Moreover, knock-down of p300 or addition of p300 inhibitor resulted in obviously reduced HSP70 expression by NS31 or GCRV infection suggesting that the well-characterized heat-shock...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Yu Fei Guangyao Hu Jiehua Xu Siyang Song Zhe Zhao Liqun Lu Source Type: research
NLRC3 negatively regulates Pasteurella multocida-induced NF- κB signaling in rabbits
In this study, we aimed to explore the role of rabbit NLRC3 (rNLRC3) in P. multocida infection. Our findings revealed a negative correlation between the expression of rNLRC3 and inflammatory cytokines during P. multocida infection. The expression of rNLRC3 was reduced at the initial stage of P. multocida infection and then recovered. Furthermore, rNLRC3 significantly inhibited the activation of NF-κB by reducing phosphorylation and nuclear import of p65 in response to P. multocida infection. Additionally, overexpression of rNLRC3 attenuated the expression of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α. Moreo...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Mengjiao Guo Jiaqi Zhang Mingtao Li Xiaorong Zhang Yantao Wu Source Type: research
Involvement of transcriptional co-activator p300 in upregulated expression of HSP70 by aquareovirus non-structural protein NS31
In this study, we further found that either the N- or C-terminal domain of GCRV NS31 is responsible for enhancing fish HSP70 promoter transcription, and recombinant NS31 protein purified from baculovirus expression system seems to not directly bind HSP70 basic promoter in vitro by an electrophoretic mobility shift assay. However, the transcriptional co-activator p300 was identified as a potential interacting partner for NS31 by pull-down assay. Moreover, knock-down of p300 or addition of p300 inhibitor resulted in obviously reduced HSP70 expression by NS31 or GCRV infection suggesting that the well-characterized heat-shock...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Yu Fei Guangyao Hu Jiehua Xu Siyang Song Zhe Zhao Liqun Lu Source Type: research
NLRC3 negatively regulates Pasteurella multocida-induced NF- κB signaling in rabbits
In this study, we aimed to explore the role of rabbit NLRC3 (rNLRC3) in P. multocida infection. Our findings revealed a negative correlation between the expression of rNLRC3 and inflammatory cytokines during P. multocida infection. The expression of rNLRC3 was reduced at the initial stage of P. multocida infection and then recovered. Furthermore, rNLRC3 significantly inhibited the activation of NF-κB by reducing phosphorylation and nuclear import of p65 in response to P. multocida infection. Additionally, overexpression of rNLRC3 attenuated the expression of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α. Moreo...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Mengjiao Guo Jiaqi Zhang Mingtao Li Xiaorong Zhang Yantao Wu Source Type: research
Involvement of transcriptional co-activator p300 in upregulated expression of HSP70 by aquareovirus non-structural protein NS31
In this study, we further found that either the N- or C-terminal domain of GCRV NS31 is responsible for enhancing fish HSP70 promoter transcription, and recombinant NS31 protein purified from baculovirus expression system seems to not directly bind HSP70 basic promoter in vitro by an electrophoretic mobility shift assay. However, the transcriptional co-activator p300 was identified as a potential interacting partner for NS31 by pull-down assay. Moreover, knock-down of p300 or addition of p300 inhibitor resulted in obviously reduced HSP70 expression by NS31 or GCRV infection suggesting that the well-characterized heat-shock...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Yu Fei Guangyao Hu Jiehua Xu Siyang Song Zhe Zhao Liqun Lu Source Type: research
NLRC3 negatively regulates Pasteurella multocida-induced NF- κB signaling in rabbits
In this study, we aimed to explore the role of rabbit NLRC3 (rNLRC3) in P. multocida infection. Our findings revealed a negative correlation between the expression of rNLRC3 and inflammatory cytokines during P. multocida infection. The expression of rNLRC3 was reduced at the initial stage of P. multocida infection and then recovered. Furthermore, rNLRC3 significantly inhibited the activation of NF-κB by reducing phosphorylation and nuclear import of p65 in response to P. multocida infection. Additionally, overexpression of rNLRC3 attenuated the expression of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α. Moreo...
Source: Developmental and Comparative Immunology - October 11, 2023 Category: Allergy & Immunology Authors: Mengjiao Guo Jiaqi Zhang Mingtao Li Xiaorong Zhang Yantao Wu Source Type: research
A novel DM9-containing protein 7 involved in regulating the expression of CgMyD88 and CgIL-17 in oyster Crassostrea gigas
Dev Comp Immunol. 2023 Oct 4;150:105076. doi: 10.1016/j.dci.2023.105076. Online ahead of print.ABSTRACTThe DM9-containing proteins have been identified as pattern recognition receptors (PRRs) to recognize invading pathogens and subsequently mediate downstream signal pathways, playing essential roles in innate immune responses of molluscs. In the present study, a novel DM9-containing protein (named as CgDM9CP-7) was identified from Pacific oyster Crassostrea gigas, which contained two tandem DM9 repeats similar to the previously identified CgDM9CPs. The mRNA transcripts of CgDM9CP-7 were found to be constitutively expressed...
Source: Developmental and Comparative Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yinan Li Xingye Lian Wenwen Yang Jinyuan Leng Jiejie Sun Yu Liu Siqi Fan Lingling Wang Linsheng Song Source Type: research
A novel DM9-containing protein 7 involved in regulating the expression of CgMyD88 and CgIL-17 in oyster Crassostrea gigas
Dev Comp Immunol. 2023 Oct 4;150:105076. doi: 10.1016/j.dci.2023.105076. Online ahead of print.ABSTRACTThe DM9-containing proteins have been identified as pattern recognition receptors (PRRs) to recognize invading pathogens and subsequently mediate downstream signal pathways, playing essential roles in innate immune responses of molluscs. In the present study, a novel DM9-containing protein (named as CgDM9CP-7) was identified from Pacific oyster Crassostrea gigas, which contained two tandem DM9 repeats similar to the previously identified CgDM9CPs. The mRNA transcripts of CgDM9CP-7 were found to be constitutively expressed...
Source: Developmental and Comparative Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yinan Li Xingye Lian Wenwen Yang Jinyuan Leng Jiejie Sun Yu Liu Siqi Fan Lingling Wang Linsheng Song Source Type: research
