Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A novel DM9-containing protein 7 involved in regulating the expression of CgMyD88 and CgIL-17 in oyster Crassostrea gigas
Dev Comp Immunol. 2023 Oct 4:105076. doi: 10.1016/j.dci.2023.105076. Online ahead of print.ABSTRACTThe DM9-containing proteins have been identified as pattern recognition receptors (PRRs) to recognize invading pathogens and subsequently mediate downstream signal pathways, playing essential roles in innate immune responses of molluscs. In the present study, a novel DM9-containing protein (named as CgDM9CP-7) was identified from Pacific oyster Crassostrea gigas, which contained two tandem DM9 repeats similar to the previously identified CgDM9CPs. The mRNA transcripts of CgDM9CP-7 were found to be constitutively expressed in ...
Source: Developmental and Comparative Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yinan Li Xingye Lian Wenwen Yang Jinyuan Leng Jiejie Sun Yu Liu Siqi Fan Lingling Wang Linsheng Song Source Type: research

Histopathological observations and comparative transcriptome analysis of Ophiocordyceps sinensis infection of Hepialus xiaojinensis in the early stage
This study provides a comprehensive resource for analyzing the mechanism of H. xiaojinensis and O. sinensis interaction.PMID:37797777 | DOI:10.1016/j.dci.2023.105067 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - October 5, 2023 Category: Allergy & Immunology Authors: Xiuwen Bao Haoran Song Liying He Yong Li Shuqi Niu Jinlin Guo Source Type: research

Molecular cloning and functional characterization of duck MRE11
In this study, we cloned and characterized the full-length sequence of duck MRE11 (duMRE11) from duck embryo fibroblasts (DEFs) for the first time. The duMRE11 gene encoded a protein of 703 amino acid residues and showed the highest sequence similarity to goose MRE11. Quantitative real-time PCR analysis showed that duMRE11 was ubiquitously expressed in all tissues examined, with particularly high expression levels in the bursa of Fabricius, thymus and spleen. Overexpression of duMRE11 in DEFs led to the activation of IRF1 and NF-κB and the production of IFN-β. Furthermore, knockdown of duMRE11 significantly reduced the a...
Source: Developmental and Comparative Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Jinyue Yang Peng Zhou Wanrong Wu Qingxiang Zhang Dong Chen Rui Luo Source Type: research

Pattern recognition receptors involved in the immune system of hagfish (Eptatretusburgeri)
Dev Comp Immunol. 2023 Sep 21:105065. doi: 10.1016/j.dci.2023.105065. Online ahead of print.ABSTRACTThe initial defense against invading pathogenic microbes is the activation of innate immunity by binding of pattern recognition receptors (PRRs) to pathogen associating molecular patterns (PAMPs). To explain the action of PRRs from hagfish, one of the extant jawless vertebrates, we purified the GlcNAc recognition complex (GRC) from serum using GlcNAc-agarose. The GRC comprises four proteins of varying molecular masses: 19 kDa, 26 kDa, 27 kDa, and 31 kDa. Exposure of Escherichia coli to the GRC led to the phagocytic activatio...
Source: Developmental and Comparative Immunology - September 23, 2023 Category: Allergy & Immunology Authors: Kenya Arata Tomokazu Yamaguchi Kazufumi Takamune Shinya Yasumoto Masakazu Kondo Shin-Ichi Kato Michiyasu Yoshikuni Kaoru Ohno Yoko Kato-Unoki Genya Okada Tamotsu Fujii Source Type: research