Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cloning and expression analysis of Janus activated kinase family genes from spotted seabass (Lateolabrax maculatus)
Dev Comp Immunol. 2024 Mar 22:105169. doi: 10.1016/j.dci.2024.105169. Online ahead of print.ABSTRACTJanus kinases (JAKs) are important components of the JAK-STAT signaling pathway and play vital roles in innate immunity, autoimmune diseases, and inflammation. However, information about JAKs remains largely unknown in the spotted seabass, a fish species of Perciformes with great commercial value in the aquaculture industry. The aims of this study are to obtain the complete cDNA sequences of JAKs (JAK1, JAK2A, JAK2B, JAK3 and TYK2) from spotted seabass and to investigate their roles upon stimulation with lipopolysaccharides ...
Source: Developmental and Comparative Immunology - March 24, 2024 Category: Allergy & Immunology Authors: Ke Fan Qian Gao Chuanguo Cai Yushuai Xie Zhitao Qi Zhaosheng Sun Jiasong Xie Jiaqi Gao Source Type: research

CgPHB2 involved in the haemocyte mitophagy in response to Vibrio splendidus stimulation in Pacific oyster Crassostrea gigas
Dev Comp Immunol. 2024 Mar 22;156:105168. doi: 10.1016/j.dci.2024.105168. Online ahead of print.ABSTRACTProhibitin2 (PHB2) is recently identified as a novel inner membrane mitophagy receptor to mediate mitophagy. In the present study, the function of CgPHB2 in mediating mitophagy in response to Vibrio splendidus stimulation was investigated in Crassostrea gigas. CgPHB2 protein was mainly distributed in the cytoplasm of three subpopulations of haemocytes. After V. splendidus stimulation, the expressions of CgPHB2 mRNA in haemocytes were up-regulated significantly at 6, 12 and 24 h, and the abundance of CgPHB2 protein was al...
Source: Developmental and Comparative Immunology - March 24, 2024 Category: Allergy & Immunology Authors: Shurong Li Jiejie Sun Yinan Li Xiaoqian Lv Lingling Wang Linsheng Song Source Type: research

USP46 promotes the interferon antiviral signaling in black carp by deubiquitinating TBK1
In this study we cloned and identified bcUSP46, a homolog of USP46 from black carp. We discovered that overexpression of bcUSP46 enhanced the transcription of interferon (IFN) promoters and increased the expression of IFN, PKR, and Mx1. In addition, bcUSP46 knockdown significantly inhibited the expression of ISG genes, as well as the antiviral activity of the host cells. Interestingly, when bcUSP46 was co-expressed with the RLR factors, it significantly enhanced the activity of the IFN promoter mediated by these factors, especially TANK-binding kinase 1 (TBK1). The subsequent co-immunoprecipitation (co-IP) and immunofluore...
Source: Developmental and Comparative Immunology - March 24, 2024 Category: Allergy & Immunology Authors: Juanjuan Shu Can Yang Yujia Miao Jinyi Li Tianle Zheng Jun Xiao Weiguang Kong Zhen Xu Hao Feng Source Type: research

CgPHB2 involved in the haemocyte mitophagy in response to Vibrio splendidus stimulation in Pacific oyster Crassostrea gigas
Dev Comp Immunol. 2024 Mar 22:105168. doi: 10.1016/j.dci.2024.105168. Online ahead of print.ABSTRACTProhibitin2 (PHB2) is recently identified as a novel inner membrane mitophagy receptor to mediate mitophagy. In the present study, the function of CgPHB2 in mediating mitophagy in response to Vibrio splendidus stimulation was investigated in Crassostrea gigas. CgPHB2 protein was mainly distributed in the cytoplasm of three subpopulations of haemocytes. After V. splendidus stimulation, the expressions of CgPHB2 mRNA in haemocytes were up-regulated significantly at 6, 12 and 24 h, and the abundance of CgPHB2 protein was also e...
Source: Developmental and Comparative Immunology - March 24, 2024 Category: Allergy & Immunology Authors: Shurong Li Jiejie Sun Yinan Li Xiaoqian Lv Lingling Wang Linsheng Song Source Type: research

A novel C-type lectin protein (BjCTL5) interacts with apoptosis stimulating proteins of p53 (ASPP) to activate NF- κB signaling pathway in primitive chordate
In this study, we examined the composition of CTLs in Branchiostoma japonicum, identifying a total of 272 CTLs. These CTLs underwent further analysis concerning domain arrangement, tandem and segmental duplication events. A multidomain C-type lectin gene, designated as BjCTL5, encompassing CLECT, KR, CUB, MAM, and SR domains, was the focal point of our investigation. BjCTL5 exhibits ubiquitous expression across all detected tissues and is responsive to stimulation by LPS, mannose, and poly (I:C). The recombinant protein of BjCTL5 can bind to Escherichia coli and Staphylococcus aureus, inducing their agglutination and inhib...
Source: Developmental and Comparative Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Wenyu Fan Jianing Chen Yunpeng Cao Jiabo Tan Jinlong Li Su Wang Ping Jin Xiaojun Song Source Type: research

Climate change can impair bacterial pathogen defences in sablefish via hypoxia-mediated effects on adaptive immunity
Dev Comp Immunol. 2024 Mar 21:105161. doi: 10.1016/j.dci.2024.105161. Online ahead of print.ABSTRACTLow-oxygen levels (hypoxia) in aquatic habitats are becoming more common because of global warming and eutrophication. However, the effects on the health/disease status of fishes, the world's largest group of vertebrates, are unclear. Therefore, we assessed how long-term hypoxia affected the immune function of sablefish, an ecologically and economically important North Pacific species, including the response to a formalin-killed Aeromonas salmonicida bacterin. Sablefish were held at normoxia or hypoxia (100% or 40% air satur...
Source: Developmental and Comparative Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Robine H J Leeuwis Jennifer R Hall F ábio S Zanuzzo Nicole Smith Kathy A Clow Surendra Kumar Ignacio Vasquez Frederick W Goetz Stewart C Johnson Matthew L Rise Javier Santander A Kurt Gamperl Source Type: research

Transcriptome profiling of lumpfish (Cyclopterus lumpus) head kidney to Renibacterium salmoninarum at early and chronic infection stages
This study provides a complete depiction of diverse immune mechanisms dysregulated by R. salmoninarum in lumpfish and opens new avenues to develop immune prophylactic tools to prevent BKD.PMID:38499166 | DOI:10.1016/j.dci.2024.105165 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Hajarooba Gnanagobal Setu Chakraborty Ignacio Vasquez Joy Chukwu-Osazuwa Trung Cao Ahmed Hossain My Dang Katherine Valderrama Surendra Kumar Gabriela Bindea Stephen Hill Danny Boyce Jennifer R Hall Javier Santander Source Type: research