Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Pentraxins in invertebrates and vertebrates: From structure, function and evolution to clinical applications
Dev Comp Immunol. 2023 Sep 19:105064. doi: 10.1016/j.dci.2023.105064. Online ahead of print.ABSTRACTThe immune system is divided into two broad categories, consisting of innate and adaptive immunity. As recognition and effector factors of innate immunity and regulators of adaptive immune responses, lectins are considered to be important defense chemicals against microbial pathogens, cell trafficking, immune regulation, and prevention of autoimmunity. Pentraxins, important members of animal lectins, play a significant role in protecting the body from pathogen infection and regulating inflammatory reactions. They can recogni...
Source: Developmental and Comparative Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Yuying Wang Wei Chen Shuo Ding Wenjun Wang Changliu Wang Source Type: research

Evolution of the gasdermin family and pyroptosis
Dev Comp Immunol. 2023 Sep 19:105060. doi: 10.1016/j.dci.2023.105060. Online ahead of print.ABSTRACTGasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane. Although pyroptosis has been widely described in mammals, the importance of gasdermins and gasdermin-like proteins in inducing cell death in other vertebrates, in invertebrates and in other taxa including fungi and bacteria is still being determin...
Source: Developmental and Comparative Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Diego Angosto-Bazarra Adriana Guijarro Pablo Pelegr ín Source Type: research

A galectin-9 involved in the microbial recognition and haemocyte autophagy in the Pacific oyster Crassostrea gigas
Dev Comp Immunol. 2023 Sep 18:105063. doi: 10.1016/j.dci.2023.105063. Online ahead of print.ABSTRACTGalectin-9 is a tandem-repeat type member of galectin family participating in various immune responses, such as cell agglutination, phagocytosis, and autophagy. In the present study, a tandem repeat galectin-9 (defined as CgGal-9) was identified from Pacific oyster Crassostrea gigas, which consisted of two conserved carbohydrate recognition domains (CRDs) joined by a linker peptide. CgGal-9 was closely clustered with CaGal-9 from C. angulata, and they were assigned into the branch of invertebrate galectin-9s in the phylogene...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Yang Jiejie Sun Wei Wu Zhen Xing Xiaoxue Yan Xiaoqian Lv Lingling Wang Linsheng Song Source Type: research

Discovery of BbX transcription factor in the patagonian blennie: Exploring expression changes following combined bacterial and thermal stress exposure
Dev Comp Immunol. 2023 Sep 18:105056. doi: 10.1016/j.dci.2023.105056. Online ahead of print.ABSTRACTHigh-Mobility Group (HMG) proteins are involved in different processes such as transcription, replication, DNA repair, and immune response. The role of HMG proteins in the immune response of fish has been studied mainly for HMGB1, where its expression can be induced by the stimulation of viral/bacterial PAMPs and can act as a proinflammatory mediator and as a global regulator of transcription in response to temperature. However, for BbX this role remains to be discovered. In this work, we identified the BbX of E. maclovinus ...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Danixa Mart ínez Daniela Nualart Carlos Loncoman Juan C Opazo Kattina Zabala Francisco J Morera Gonzalo A Mardones Luis Vargas-Chacoff Source Type: research

Alternative splicing variants of stimulator of interferon genes (STING) from Asian seabass (Lates calcarifer) and their immune response against red spotted grouper nervous necrosis virus (RGNNV)
Dev Comp Immunol. 2023 Sep 17:105062. doi: 10.1016/j.dci.2023.105062. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING, also known as MITA/ERYS/MPYS) is an adaptor molecule that plays a crucial role in the RLR pathway and responds to DNA and RNA viruses. In the present study, we have identified two novel isoforms of STING (the canonical form named as LcSTINGa and its alternative splicing isoform named as LcSTINGb) from teleost Lates calcarifer. LcSTINGa has an ORF of 1230 bp, encoding a 409 amino acid protein, while its alternative splicing variant, LcSTINGb, features an ORF of 987 bp, encoding 328 a...
Source: Developmental and Comparative Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Krishnapriya Raji Sathyan Avinash Premraj Mansi Chaudhary Rajesh Ramachandran Sajeevan Thavarool Puthiyedathu Source Type: research

Black carp RIOK3 suppresses MDA5-mediated IFN signaling in the antiviral innate immunity
Dev Comp Immunol. 2023 Sep 16:105059. doi: 10.1016/j.dci.2023.105059. Online ahead of print.ABSTRACTIn mammals, right open reading frame kinase 3 (RIOK3) is related with cancer development and immune regulation. To explore the role of teleost RIOK3 in the antiviral innate immunity, the homolog of RIOK3 (bcRIOK3) from black carp (Mylopharyngodon piceus) has been cloned and characterized in this study. Sequence analysis revealed that bcRIOK3 is conserved in vertebrates. The transcription of bcRIOK3 varied in host cells in response to the stimulation of spring viremia of carp virus (SVCV), poly (I:C), and LPS. Immunoblotting ...
Source: Developmental and Comparative Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Qian Li Lixia Xie Jiaji Pan Yixuan He Enhui Wang Hui Wu Jun Xiao Hao Feng Source Type: research

Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology
Dev Comp Immunol. 2023 Sep 15:105061. doi: 10.1016/j.dci.2023.105061. Online ahead of print.ABSTRACTCamelids are economically and socially important in several parts of the world and might carry pathogens with epizootic or zoonotic potential. However, biological research in these species is limited due to lack of reagents. Here, we developed RT-qPCR assays to quantify a panel of camelid innate and adaptive immune response genes, which can be monitored in a single run. The assays were validated with PHA, PMA-ionomycin, and Poly I:C-stimulated PBMCs from alpaca, dromedary camel and llama, including normalization by multiple ...
Source: Developmental and Comparative Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Jordi Rodon Nigeer Te Maria Ballester Joaquim Segal és J úlia Vergara-Alert Albert Bensaid Source Type: research

Salmonella delivers H9N2 influenza virus antigens via a prokaryotic and eukaryotic dual-expression vector and elicits bivalent protection against avian influenza and fowl typhoid
Dev Comp Immunol. 2023 Sep 13:105058. doi: 10.1016/j.dci.2023.105058. Online ahead of print.ABSTRACTThe H9N2 avian influenza virus significantly affects the health of poultry and humans. We identified a prokaryotic and eukaryotic dual-expression vector system, pJHL270, that can provide simultaneous MHC class I and II stimulation of the host immune system, and we designed vaccine antigens by selecting the consensus HA1 sequence and M2e antigens from H9N2 virus circulating in South Korea from 2000 to 2021. The genes were cloned into the pJHL270 vector, and the cloned plasmid was delivered by a live-attenuated Salmonella Gall...
Source: Developmental and Comparative Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Chamith Hewawaduge Jun Kwon Chandran Sivasankar Ji-Young Park Amal Senevirathne John Hwa Lee Source Type: research