Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cytotoxic activity and gene expression during in vitro adaptive cell-mediated cytotoxicity of head-kidney cells from betanodavirus-infected European sea bass
Dev Comp Immunol. 2023 Dec 23:105124. doi: 10.1016/j.dci.2023.105124. Online ahead of print.ABSTRACTCell-mediated cytotoxicity (CMC) is essential in eradicating virus-infected cells, involving CD8+ T lymphocytes (CTLs) and natural killer (NK) cells, through the activation of different pathways. This immune response is well-studied in mammals but scarcely in teleost fish. Our aim was to investigate the adaptive CMC using head-kidney (HK) cells from European sea bass infected at different times with nodavirus (NNV), as effector cells, and the European sea bass brain cell line (DLB-1) infected with different NNV genotypes, as...
Source: Developmental and Comparative Immunology - December 25, 2023 Category: Allergy & Immunology Authors: Miguel A Garc ía-Álvarez Elena Chaves-Pozo Alberto Cuesta Source Type: research

Counteracting immunotyrosine-based signaling motifs augment zebrafish leukocyte immune-type receptor-mediated phagocytic activity
Dev Comp Immunol. 2023 Dec 20:105121. doi: 10.1016/j.dci.2023.105121. Online ahead of print.ABSTRACTLeukocyte immune-type receptors (LITRs) represent a polymorphic and polygenic family of immunoregulatory proteins originally discovered in channel catfish (Ictalurus punctatus; IpLITRs). Belonging to the immunoglobulin superfamily (IgSF), IpLITRs are generally classified as stimulatory or inhibitory types based on their utilization of various intracellular tyrosine-based signaling motifs. While research has shown that IpLITRs can activate as well as abrogate different immune cell effector responses including phagocytosis, re...
Source: Developmental and Comparative Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Rikus R Niemand James L Stafford Source Type: research

Identification of the NOD-like receptor family of golden pompano and expression in response to bacterial and parasitic exposure reveal its key role in innate immunity
This study presents a genome-wide identification of NOD-like receptors (NLRs) in the golden pompano, key to its innate immunity. We identified 30 ToNLRs, analyzing their chromosomal positions, characteristics, evolutionary relationships, evidence of positive selection, and synteny with the yellowtail kingfish. Our findings categorize these NLRs into three main subgroups: NLRA, NLRC, and the distinct ToNLRX1. Post-exposure to Streptococcus agalactiae, most ToNLRs increased expression in the spleen, whereas NLRC3like13, NLRC3like16, and NLRC3like19 so in the kidneys. Upon Cryptocaryon irritans exposure, we categorized our gr...
Source: Developmental and Comparative Immunology - December 22, 2023 Category: Allergy & Immunology Authors: Jin-Min Pan Yu Liang Ke-Cheng Zhu Hua-Yang Guo Bao-Suo Liu Nan Zhang Dian-Chang Zhang Source Type: research

Low-dose of formalin-inactivated Vibrio alginolyticus protects Crassostrea gigas from secondary infection and confers broad-spectrum Vibrio resistance on offspring
Dev Comp Immunol. 2023 Dec 16;152:105122. doi: 10.1016/j.dci.2023.105122. Online ahead of print.ABSTRACTAn increasing number of evidences have shown that invertebrate taxa can be primed to produce immune memory to resist the secondary infection of pathogens, which was considered as a viable option to protect invertebrates from pathogens. In this work, we compared the protective effect of several different immune priming methods on the Vibrio alginolyticus secondary infection of the Crassostrea gigas. The results showed that C. gigas primed with live V. alginolyticus had higher ROS level, which led to hemocytes necrosis and...
Source: Developmental and Comparative Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Hebing Wang Ben Yang Qi Li Shikai Liu Source Type: research

Low-dose of formalin-inactivated Vibrio alginolyticus protects Crassostrea gigas from secondary infection and confers broad-spectrum Vibrio resistance on offspring
Dev Comp Immunol. 2023 Dec 15:105122. doi: 10.1016/j.dci.2023.105122. Online ahead of print.ABSTRACTAn increasing number of evidences have shown that invertebrate taxa can be primed to produce immune memory to resist the secondary infection of pathogens, which was considered as a viable option to protect invertebrates from pathogens. In this work, we compared the protective effect of several different immune priming methods on the Vibrio alginolyticus secondary infection of the Crassostrea gigas. The results showed that C. gigas primed with live V. alginolyticus had higher ROS level, which led to hemocytes necrosis and hig...
Source: Developmental and Comparative Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Hebing Wang Ben Yang Qi Li Shikai Liu Source Type: research