Developmental and Comparative Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The goldfish primary kidney macrophage system
Dev Comp Immunol. 2023 Nov 15:105100. doi: 10.1016/j.dci.2023.105100. Online ahead of print.ABSTRACTMiodrag (Mike) Belosevic and collaborators profoundly influenced the development of primary kidney macrophage culturing system (PKM) to study fish immunology in various aspects of comparative immunology. Their application of using PKM model, opened a new path for studying the development of macrophages, regulation of hematopoiesis, and cell specific response against various pathogens. By measuring histopathological and immunological outcomes, the biological implications of a variety of cytokines and signal transduction molec...
Source: Developmental and Comparative Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Xionglin Li Xinyuan Yue Jiasong Xie Source Type: research

Corrigendum to "Receptor complex and signalling pathway of the two type II IFNs, IFN- γ and IFN-γrel in mandarin fish or the so-called Chinese perch Siniperca chuatis" [Dev. Comp. Immunol. 97 (2019) 98-112]
Dev Comp Immunol. 2023 Nov 14:105092. doi: 10.1016/j.dci.2023.105092. Online ahead of print.NO ABSTRACTPMID:37973478 | DOI:10.1016/j.dci.2023.105092 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Li Li Shan Nan Chen Zubair Ahmed Laghari Bei Huang Hui Jun Huo P Nie Source Type: research

The antiviral effects of TRIM23 and TRIM32 proteins in rainbow trout (Oncorhynchus mykiss)
In this study, we found that TRIM proteins exhibited the highest expression levels in immune organs such as spleen and kidney during IHNV infection in rainbow trout, meanwhile, we successfully amplified TRIM23 and TRIM32 from diseased rainbow trout and analyzed their gene sequences, revealing that rainbow trout TRIM23 and TRIM32 proteins are closely related to Atlantic salmon and Chinook salmon; In this experiment, the TRIM23 and TRIM32 protein genes were resoundingly constructed as a recombinant plasmids and expressed in CHSE-214 cells. Upon transfected with the recombinant plasmid, followed by viral infection, significan...
Source: Developmental and Comparative Immunology - November 15, 2023 Category: Allergy & Immunology Authors: Mengmeng Zhang Jinhui Sun Yanxue Shi Futing Zhang Shuaibo Li Dandan Zhao Guangqing Wu Linsong Li Zhiruo Miao Min Liu Source Type: research

Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters
In this study, we identified that the overexpression of lncRNA-CR11538 inhibits the expression of antimicrobial peptides (AMPs) Dpt and AttA in Drosophila upon Escherichia coli (E. coli) infection, and influences the survival rate of flies after E. cloacae infection. Mechanically, lncRNA-CR11538 decoys Relish away from AMPs promoter region. We further revealed that Relish can promote the transcription of lncRNA-CR11538. After analyzing the dynamic expression profile of lncRNA-CR11538 during Imd immune response, we put forward a hypothesis that in the late stage of Imd immune response, lncRNA-CR11538 can be activated by Rel...
Source: Developmental and Comparative Immunology - November 13, 2023 Category: Allergy & Immunology Authors: Yu Huang Tan Wang Chun Jiang Shengjie Li Hongjian Zhou Ruimin Li Source Type: research

Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract
Dev Comp Immunol. 2023 Nov 10:105096. doi: 10.1016/j.dci.2023.105096. Online ahead of print.ABSTRACTChickens exhibit a distinct immune architecture characterised by the absence of draining lymph nodes and the presence of a well-developed mucosa-associated lymphoid tissue. The structure and spatiotemporal development of chicken lymphoid tissues in the intestine are poorly documented. The macroscopically indistinct structure of chicken Peyer's patches has impeded studies into their development. The generation of CSF1R-eGFP reporter transgenic chickens enables visualisation of the development, organisation and extent of chick...
Source: Developmental and Comparative Immunology - November 12, 2023 Category: Allergy & Immunology Authors: Safieh Zeinali Kate Sutton Lonneke Vervelde Source Type: research

The expression, function, and network regulation of circDNAJB6 in chicken macrophages under lipopolysaccharide (LPS) stimulation
This study has provided and broadened a better understanding the function of circDNAJB6, which may exert potential biomarkers and act as potential targets for the treatment of bacterial infection.PMID:37951323 | DOI:10.1016/j.dci.2023.105095 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Jishuang Tan Paizelaiti Sahaer Huan Li Wei Han Hongyan Sun Source Type: research

Mechanisms of type I interferon production by chicken TLR21
In this study, we focused on TLR21, an avian TLR that recognizes DNA motifs commonly found in bacterial genomic DNA, specifically unmethylated CpG motifs. TLR21 is believed to act as a functional homologue to mammalian TLR9. By analysing TLR21 signalling in chickens, we sought to elucidate avian TLR21 activation outputs in parallel to that of other nucleic acid species. Our analyses revealed that chicken TLR21 (chTLR21) triggers the activation of NF-κB and induces a potent type-I interferon response in chicken macrophages, similar to the signalling cascades observed in mammalian TLR9 activation. Notably, the transcription...
Source: Developmental and Comparative Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Rodrigo Guabiraba Damaris Ribeiro Rodrigues Paul T Manna M élanie Chollot Vincent Saint-Martin Sascha Trapp Marisa Oliveira Clare E Bryant Brian J Ferguson Source Type: research

Dietary supplementation with pseudostellaria heterophylla polysaccharide enhanced immunity and changed mRNA expression of spleen in chicks
Dev Comp Immunol. 2023 Nov 9:105094. doi: 10.1016/j.dci.2023.105094. Online ahead of print.ABSTRACTIn recent years, increasing interest has focused on natural components extracted from plants, among which plant polysaccharides as natural immunomodulators that can promote animal immunity. The present study was performed to investigate the effect of feed supplement Pseudostellaria Heterophylla Polysaccharide (PHP) on serum Immunoglobulins, T lymphocyte subpopulations, Cytokines and Lysozyme (LZM) activity in chicks. In addition, the influence of PHP on splenic gene expression was investigated by transcriptome sequencing. Fou...
Source: Developmental and Comparative Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Zhaoyan Zhu Yange Yu Bingxin Wang Mengxia Ding Yadong Tian Ruirui Jiang Guirong Sun Ruili Han Xiangtao Kang Fengbin Yan Yujie Guo Source Type: research

Recent contributions to mechanisms of Innate Immunity of Fish
Dev Comp Immunol. 2023 Nov 2:105089. doi: 10.1016/j.dci.2023.105089. Online ahead of print.NO ABSTRACTPMID:37923097 | DOI:10.1016/j.dci.2023.105089 (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - November 3, 2023 Category: Allergy & Immunology Authors: Pin Nie Source Type: research

Identification of an essential role against shrimp pathogens of prophenoloxidase activating enzyme 1 (PPAE1) from Fenneropenaeus merguiensis hemocytes
Dev Comp Immunol. 2023 Nov 3;151:105088. doi: 10.1016/j.dci.2023.105088. Online ahead of print.ABSTRACTProphenoloxidase (proPO) activating enzymes, known as PPAEs, are pivotal in activating the proPO system within invertebrate immunity. A cDNA encoding a PPAE derived from the hemocytes of banana shrimp, Fenneropenaeus merguiensis have cloned and analyzed, referred to as FmPPAE1. The open reading frame of FmPPAE1 encompasses 1392 base pairs, encoding a 464-amino acid peptide featuring a presumed 19-amino acid signal peptide. The projected molecular mass and isoelectric point of this protein stand at 50.5 kDa and 7.82, respe...
Source: Developmental and Comparative Immunology - November 3, 2023 Category: Allergy & Immunology Authors: Ratiporn Thongsoi Siriluk Maskaew Panumas Puechpon Benjaporn Noppradit Napassawan Inaek Prapaporn Utarabhand Phanthipha Runsaeng Source Type: research