Cleavage of gasdermin by apoptotic caspases triggers pyroptosis restricting bacterial colonization in Hydra

In conclusion, these results suggest that GSDME-dependent pyroptosis may be an ancient and conserved host defense mechanism, which may contribute to better understanding on the origin and evolution of GSDMs.PMID:38325499 | DOI:10.1016/j.dci.2024.105139

Source: Developmental and Comparative Immunology - February 7, 2024 Category: Allergy & Immunology Authors: Shuxin Li Xiaoyang Lu Xiuqing Lin Yuanxing Zhang Qin Liu Shouwen Chen Source Type: research