Clinical, Cosmetic and Investigational Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rosacea: Practical Guidance and Challenges for Clinical Management
Clin Cosmet Investig Dermatol. 2024 Jan 23;17:175-190. doi: 10.2147/CCID.S391705. eCollection 2024.ABSTRACTRosacea is a common chronic dermatosis. Clinically, rosacea can present with flushing, erythema, papules, pustules, telangiectasias, phymatous changes, pruritus, burning, and stinging. In 2017, the National Rosacea Society Expert Committee recommended a phenotype-based classification for therapy. In this review, we identify monotherapies and multimodal treatment approaches for the clinical management of rosacea including topical, systemic, laser and light, alternative, and combination therapies.PMID:38283794 | PMC:PMC...
Source: Clinical, Cosmetic and Investigational Dermatology - January 29, 2024 Category: Dermatology Authors: Cassidy Nguyen Guilherme Kuceki Michael Birdsall Dev Ram Sahni Vikram Nath Sahni Christopher M Hull Source Type: research

Two Novel and Three Recurrent Mutations in the Mevalonate Pathway Genes in Chinese Patients with Porokeratosis
CONCLUSION: Our results extended the mutation spectrum of mevalonate pathway genes in porokeratosis and provided useful strategies for a more accurate diagnosis and genetic counseling.PMID:38283795 | PMC:PMC10822103 | DOI:10.2147/CCID.S444985 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 29, 2024 Category: Dermatology Authors: Xiuping Wang Xiaoliang Ouyang Deng Zhang Yunxia Zhu Liang Wu Zhen Xiao Simin Yu Wei Li Chunming Li Source Type: research

Erzhiwan Ameliorates Restraint Stress- and Monobenzone-Induced Depigmentation in Mice by Inhibiting Macrophage Migration Inhibitory Factor and 8-Hydroxy-2-Deoxyguanosine
CONCLUSION: EZW ameliorates restraint stress- and monobenzone-induced depigmentation via the inhibition of MIF and 8-OHdG signaling. The findings provide a data basis of an utilization of EZW in vitiligo.PMID:38283796 | PMC:PMC10812780 | DOI:10.2147/CCID.S420385 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 29, 2024 Category: Dermatology Authors: Nan Tang Xiao-Ting Liu Xiao-Li Lin Wen-Xiu Yang Qi-Lin Li Guo-En Wang Yan-Hua Wu Source Type: research

Etanercept Combined with Glucocorticoid and Gamma Globulin for Treating Children with Toxic Epidermal Necrolysis: A Case Report
This study reports on a 7-year-old girl with TEN who did not respond to traditional therapy, such as methylprednisolone combined with gamma globulin, but was finally cured with an additional low-dose etanercept. The results showed that etanercept therapy in paediatric TEN is safe, reliable and worth recommending.PMID:38283797 | PMC:PMC10821656 | DOI:10.2147/CCID.S440476 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 29, 2024 Category: Dermatology Authors: Yanhua Fu Yuanyuan Xiao Tianji Gao Junxiu Zhang Tianjiao Wang Source Type: research

Secukinumab in Hidradenitis Suppurativa Patients Who Failed Adalimumab: A 52-Week Real-Life Study
CONCLUSION: The results of our study highlight that treatment with secukinumab in patients with severe HS who failed adalimumab may be a safe and effective therapeutic weapon.PMID:38283798 | PMC:PMC10821645 | DOI:10.2147/CCID.S449367 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 29, 2024 Category: Dermatology Authors: Fabrizio Martora Claudio Marasca Sara Cacciapuoti Federica Fariello Luca Potestio Teresa Battista Massimiliano Scalvenzi Matteo Megna Source Type: research

Effects of Parallel Contact Cooling on Pulsed-Type, Bipolar Radiofrequency-Induced Tissue Reactions in an in vivo Porcine Model
CONCLUSION: PCC-assisted RF treatment, utilizing an invasive bipolar microneedling device, enhanced RF-induced skin reactions in the mid to deep dermis while preserving the epidermis and upper papillary dermis from excessive thermal tissue injury.PMID:38259431 | PMC:PMC10802173 | DOI:10.2147/CCID.S446814 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 23, 2024 Category: Dermatology Authors: Sung Bin Cho Yea-Jin Lee Sun Young Kang Min Choi Bora Kim Jin-Chul Ahn Source Type: research

The Application of Modified Kite Flap: A Novel Technique for Reconstruction of Defects in Areas with High Tension
CONCLUSION: The modified method enables a significantly shortened advancement distance of flaps, more flexible flap movement, and sacrifice of healthy tissue to be minimal, and significantly diminished tension for closure. Approximately half the width and length of traditional V-Y flaps were used in this flap donor. Preserving the flap limbs, which were often removed with the traditional V-Y flaps, was also applied to fill defects. Modified kite flaps are a suitable option for the repair of defects in areas with high tension.PMID:38250637 | PMC:PMC10798051 | DOI:10.2147/CCID.S440669 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 22, 2024 Category: Dermatology Authors: Qiaochu Zhou Source Type: research

Superficial Acral Fibromyxoma: A Report of Two Cases with CD68 Expression
Clin Cosmet Investig Dermatol. 2024 Jan 17;17:117-123. doi: 10.2147/CCID.S441055. eCollection 2024.ABSTRACTSuperficial Acral fibroma (SAF), also known as osteofibroma, is a rare fibromatous tumor primarily involving superficial soft tissues. Clinically, SAF typically manifests as a slow-growing, solitary, well-defined nodule or mass. Although these lesions are generally asymptomatic, some cases may present with associated pain, often linked to a history of trauma. SAF lesions commonly exhibit hemispherical, polypoid, or warty growths, with occasional occurrences of ulceration and bleeding.The majority of SAFs express CD34 ...
Source: Clinical, Cosmetic and Investigational Dermatology - January 22, 2024 Category: Dermatology Authors: Qingan Huang Yuan Li Mu Niu Gaihe Chen Source Type: research

Giant Ulcer with Necrosis on Right Vulva, Groin, and Thigh-- A Case of Necrotizing Fasciitis Associated with Erythematous Pemphigus
We report a case of a 72-year female with erythematous pemphigus who developed erythema, swelling and ulceration on right vulva, groin, and thigh. The early clinical manifestations of the patient were nonspecific and easily misdiagnosed as cellulitis. However, upon the occurrence of ulceration and necrosis, deep fungal infection, pyoderma gangrenosum or lymphoproliferative disorders were considered. The pathology suggested IgG4-related diseases, plasmacytoma et al. But at last, surgical exploration and postoperative pathology confirmed the diagnosis of necrotizing fasciitis. The patient recovered after multiple aggressive ...
Source: Clinical, Cosmetic and Investigational Dermatology - January 18, 2024 Category: Dermatology Authors: Miao Wan Xiangrong Xu Xiaojiao Zhao Xia You Guiying Zhang Hai Long Ping He Jian Long Jianjian Zhu Source Type: research

Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation
CONCLUSIONS: The hydrophilicity, cohesivity and particle size distributions vary among HA fillers manufactured with different techniques. The creation of new labels identifying products based on their unique combination of physiochemical and physical characteristics may help guide appropriate selection of HA fillers to optimize patient outcomes.PMID:38230304 | PMC:PMC10790663 | DOI:10.2147/CCID.S446429 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 17, 2024 Category: Dermatology Authors: Kaitlyn M Enright Steven F Weiner Kalpna K Durairaj Mirko S Gilardino Andreas Nikolis Source Type: research

Integrated Bioinformatics Analysis Reveals Diagnostic Biomarkers and Immune Cell Infiltration Characteristics of Solar Lentigines
CONCLUSION: Our study identified diagnostic biomarkers for SLs and explored its immunological features, enhancing the comprehension of its pathogenesis.PMID:38230305 | PMC:PMC10790640 | DOI:10.2147/CCID.S439655 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 17, 2024 Category: Dermatology Authors: Xin Yang Zhikuan Xia Yunlong Fan Yitong Xie Ge Ge Dexiu Lang Junhong Ao Danxia Yue Jiamin Wu Tong Chen Yuekun Zou Mingwang Zhang Rongya Yang Source Type: research

Essential Oil of < em > Matricaria chamomilla < /em > Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway
CONCLUSION: MCEO inhibited inflammation in HaCaT keratinocytes induced by IL-22/TNF-α/LPS, the potential mechanisms associated with inhibiting excessive activation and crosstalk between PI3K/Akt/mTOR and p38MAPK pathways. MCEO ameliorated skin injury in IMQ-induced psoriatic-like skin inflammation of mice by downregulating the levels of inflammatory cytokines but not IL-17A. Thus, anti-inflammatory plant drugs with different targets with combined applications were a potential therapeutic strategy in psoriasis.PMID:38222858 | PMC:PMC10785696 | DOI:10.2147/CCID.S445008 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 15, 2024 Category: Dermatology Authors: Guang Chen Caohua Lv Qing Nie Xin Li Yinyi Lv Guoyan Liao Shuangchun Liu Weiwei Ge Jinguang Chen Yunting Du Source Type: research

Pityriasis Rosea and Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination: A Narrative Review
Clin Cosmet Investig Dermatol. 2024 Jan 8;17:51-57. doi: 10.2147/CCID.S447834. eCollection 2024.ABSTRACTCOVID-19 pandemic completely changed every aspect of human life. Several measures were adopted to limit the spreading of the infection. Among these, vaccination was the main one. Globally, vaccination campaign was a success, showing to be efficient in controlling and preventing the SARS-Cov2 infection, reducing the risk of disease progression, hospitalization, and mortality. However, with the increasing number of vaccines administered, several cutaneous reactions were described, making dermatologists key players in their...
Source: Clinical, Cosmetic and Investigational Dermatology - January 15, 2024 Category: Dermatology Authors: Luca Potestio Fabrizio Martora Sara Cacciapuoti Matteo Megna Alessia Villani Angelo Ruggiero Source Type: research

Abrocitinib as a Novel Treatment for Multiple Skin Disorders: 3 Case Reports and a Scoping Review
Clin Cosmet Investig Dermatol. 2024 Jan 6;17:35-40. doi: 10.2147/CCID.S446369. eCollection 2024.ABSTRACTJanus kinase (JAK) inhibitors are increasingly being used in dermatology due to their broad potential in managing both local and systemic inflammation. More recently, abrocitinib, an oral JAK 1 inhibitor, has shown promising clinical efficacy in the treatment of various skin disorders beyond moderate to severe atopic dermatitis (AD). We firstly presented three cases, each with diagnosis of pyoderma gangrenosum (PG), livedoid vasculopathy (LV), or hidradenitis suppurativa (HS), and conducted a comprehensive scoping review...
Source: Clinical, Cosmetic and Investigational Dermatology - January 11, 2024 Category: Dermatology Authors: Pingjiao Chen Jingyao Liang Changxing Li Qian Li Wenyan Liu Junhui Zhu Weifeng Chen Xibao Zhang Source Type: research

Acute Genital Ulcers in a Woman Secondary to COVID-19 Infection: A Case Report
Clin Cosmet Investig Dermatol. 2024 Jan 5;17:31-34. doi: 10.2147/CCID.S445296. eCollection 2024.ABSTRACTAcute genital ulcers (AGU) have been associated with various pathogens, such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV). However, cases of AGU associated with coronavirus disease 2019 (COVID-19) are rare, and this disease significantly impairs human quality of life. In this case, we report a 37-year-old woman who presented with a five-day history of a painful genital ulcer and fever. A month earlier, she had experienced a COVID-19 infection that resolved without medical therapy. Physical examination revealed t...
Source: Clinical, Cosmetic and Investigational Dermatology - January 10, 2024 Category: Dermatology Authors: Jia Zhang Danni Wang Mingjing Chen Jiajun Li Wenxiang Huang Source Type: research