Superficial Acral Fibromyxoma: A Report of Two Cases with CD68 Expression

Clin Cosmet Investig Dermatol. 2024 Jan 17;17:117-123. doi: 10.2147/CCID.S441055. eCollection 2024.ABSTRACTSuperficial Acral fibroma (SAF), also known as osteofibroma, is a rare fibromatous tumor primarily involving superficial soft tissues. Clinically, SAF typically manifests as a slow-growing, solitary, well-defined nodule or mass. Although these lesions are generally asymptomatic, some cases may present with associated pain, often linked to a history of trauma. SAF lesions commonly exhibit hemispherical, polypoid, or warty growths, with occasional occurrences of ulceration and bleeding.The majority of SAFs express CD34 and CD99, but in the two cases we report, there was diffuse expression of CD34 and focal positive expression of CD68. CD68 positivity suggests a propensity for tumor cells to metastasize to secondary sites. Notably, previously reported cases of single SAF did not display positive CD68 expression, indicating a potential association with other aggressive tumors. However, the current clinical and pathological manifestations do not clarify the diagnosis of additional malignant tumors. Consequently, regular postoperative monitoring of the patient from the aforementioned two cases is essential to detect the presence of other malignant tumors. The significance of CD68-positive expression in this case lies in its potential association with such tumors.PMID:38250638 | PMC:PMC10800112 | DOI:10.2147/CCID.S441055
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research