Essential Oil of < em > Matricaria chamomilla < /em > Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway

CONCLUSION: MCEO inhibited inflammation in HaCaT keratinocytes induced by IL-22/TNF-α/LPS, the potential mechanisms associated with inhibiting excessive activation and crosstalk between PI3K/Akt/mTOR and p38MAPK pathways. MCEO ameliorated skin injury in IMQ-induced psoriatic-like skin inflammation of mice by downregulating the levels of inflammatory cytokines but not IL-17A. Thus, anti-inflammatory plant drugs with different targets with combined applications were a potential therapeutic strategy in psoriasis.PMID:38222858 | PMC:PMC10785696 | DOI:10.2147/CCID.S445008

Source: Clinical, Cosmetic and Investigational Dermatology - January 15, 2024 Category: Dermatology Authors: Guang Chen Caohua Lv Qing Nie Xin Li Yinyi Lv Guoyan Liao Shuangchun Liu Weiwei Ge Jinguang Chen Yunting Du Source Type: research