Clinical, Cosmetic and Investigational Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Recalcitrant Pyoderma Gangrenosum: Clinical Burden and Unmet Needs
Clin Cosmet Investig Dermatol. 2023 Aug 9;16:2143-2152. doi: 10.2147/CCID.S381490. eCollection 2023.ABSTRACTPyoderma gangrenosum (PG) is a rare, autoinflammatory disease leading to aseptic ulcers which carries a significant disease burden and is often difficult to treat, with many patients failing first-line treatment and requiring additional therapies. Such cases are typically referred to in the literature as "recalcitrant", "refractory", or "resistant", though little is known about the clinical characteristics of such cases. We performed a narrative literature review to characterize patient demographics and clinical cour...
Source: Clinical, Cosmetic and Investigational Dermatology - August 15, 2023 Category: Dermatology Authors: Sarah L Becker Rose Velasco Alex G Ortega-Loayza Source Type: research

Cemiplimab for the Treatment of Advanced Cutaneous Squamous Cell Carcinoma: Appropriate Patient Selection and Perspectives
Clin Cosmet Investig Dermatol. 2023 Aug 9;16:2135-2142. doi: 10.2147/CCID.S381471. eCollection 2023.ABSTRACTFive percent of patients with cutaneous squamous cell carcinoma develop locally advanced or metastatic disease that is not amenable to definitive surgical or radiation therapy. Cemiplimab, an antibody against programmed death receptor-1, was approved in the United States for the treatment of locally advanced and metastatic cutaneous squamous cell carcinoma in 2018. We performed a literature review on the use of cemiplimab in cutaneous squamous cell carcinoma, with an emphasis on efficacy, safety and tolerability, pat...
Source: Clinical, Cosmetic and Investigational Dermatology - August 15, 2023 Category: Dermatology Authors: Layna Mager Samantha Gardeen David R Carr Kathryn T Shahwan Source Type: research

Identification of Critical Biomarkers and Mechanisms of < em > Fructus Ligustri Lucidi < /em > on Vitiligo Using Integrated Bioinformatics Analysis
CONCLUSION: TYRP1, as a melanocyte molecular biomarker, may be closely related to the underlying mechanism of FLL in the treatment of vitiligo via the inhibition of melanocyte death.PMID:37575147 | PMC:PMC10416786 | DOI:10.2147/CCID.S413733 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 14, 2023 Category: Dermatology Authors: Tian-Shan Liang Nan Tang Ming-Hua Xian Wei-Lun Wen Chang-Jin Huang Lan-Hua Cai Qi-Lin Li Yan-Hua Wu Source Type: research

Dermatosis Neglecta Based on Exanthematous Drug Eruption Following Head Trauma: A Case Report and Literature Review
We report a 68-year-old Chinese male patient who presented with thick, yellowish-brown crusting on his face and scalp and scaly skin for 6 days. Dermoscopy revealed diffusely distributed yellow-green serescrust-like plaques with different sizes and uneven thickness on a red background, and some demonstrated dot or globular hemorrhages. We considered DN and exanthematous drug eruptions based on the combination of the clinical medication and the history before the rash.PMID:37575148 | PMC:PMC10417696 | DOI:10.2147/CCID.S419092 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 14, 2023 Category: Dermatology Authors: Liping Shi Jiaqing Zhao Linxi Zeng Lihong Wang Guoqiang Zhang Source Type: research

Emollients "Plus" are Beneficial in Both the Short and Long Term in Mild Atopic Dermatitis
CONCLUSION: Emollient+ is highly beneficial and well tolerated in mild AD with early benefits in improving AD signs and symptoms and skin hydration as well as the QoL of subjects as soon as D28.CLINICALTRIALSGOV IDENTIFIER: NCT05783453.PMID:37575149 | PMC:PMC10422989 | DOI:10.2147/CCID.S417622 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 14, 2023 Category: Dermatology Authors: Silmara Cestari Priscila Correia Delphine Kerob Source Type: research