Exploring the Clinical Features, Immunopathogenesis and Approach to Diagnosis for Generalized Pustular Psoriasis [Podcast]
Clin Cosmet Investig Dermatol. 2023 Jun 16;16:1553-1558. doi: 10.2147/CCID.S424073. eCollection 2023.ABSTRACTGeneralized pustular psoriasis is a rare presentation of psoriatic disease and is characterized by the acute onset of diffuse superficial pustules on the skin. These pustules can often coalesce, forming what's known as 'lakes of pus' that are most often seen on the trunk and on skin folds. GPP flares are often accompanied by systemic symptoms, including fever, malaise, and edema. The interleukin (IL)-36 pathway plays a central role in the development of GPP, although several other genes may be associated. The rarity...
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Tina Bhutani Jason E Hawkes Source Type: research

In vivo Guinea Pig Model Study for Evaluating Antifungal Effect of a Dual-Diode Laser with Wavelengths of 405 Nm and 635 Nm on Dermatophytosis
CONCLUSION: The guinea pig dermatophytosis model can be used to comparatively evaluate the efficacy and safety of various treatment modalities, including dual-diode lasers, for superficial fungal skin infection.PMID:37351065 | PMC:PMC10284164 | DOI:10.2147/CCID.S415679 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Jin-Chul Ahn Sang Joon Mo Min Choi Bora Kim Sung Bin Cho Source Type: research

Exploring the Clinical Features, Immunopathogenesis and Approach to Diagnosis for Generalized Pustular Psoriasis [Podcast]
Clin Cosmet Investig Dermatol. 2023 Jun 16;16:1553-1558. doi: 10.2147/CCID.S424073. eCollection 2023.ABSTRACTGeneralized pustular psoriasis is a rare presentation of psoriatic disease and is characterized by the acute onset of diffuse superficial pustules on the skin. These pustules can often coalesce, forming what's known as 'lakes of pus' that are most often seen on the trunk and on skin folds. GPP flares are often accompanied by systemic symptoms, including fever, malaise, and edema. The interleukin (IL)-36 pathway plays a central role in the development of GPP, although several other genes may be associated. The rarity...
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Tina Bhutani Jason E Hawkes Source Type: research

In vivo Guinea Pig Model Study for Evaluating Antifungal Effect of a Dual-Diode Laser with Wavelengths of 405 Nm and 635 Nm on Dermatophytosis
CONCLUSION: The guinea pig dermatophytosis model can be used to comparatively evaluate the efficacy and safety of various treatment modalities, including dual-diode lasers, for superficial fungal skin infection.PMID:37351065 | PMC:PMC10284164 | DOI:10.2147/CCID.S415679 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Jin-Chul Ahn Sang Joon Mo Min Choi Bora Kim Sung Bin Cho Source Type: research

Exploring the Clinical Features, Immunopathogenesis and Approach to Diagnosis for Generalized Pustular Psoriasis [Podcast]
Clin Cosmet Investig Dermatol. 2023 Jun 16;16:1553-1558. doi: 10.2147/CCID.S424073. eCollection 2023.ABSTRACTGeneralized pustular psoriasis is a rare presentation of psoriatic disease and is characterized by the acute onset of diffuse superficial pustules on the skin. These pustules can often coalesce, forming what's known as 'lakes of pus' that are most often seen on the trunk and on skin folds. GPP flares are often accompanied by systemic symptoms, including fever, malaise, and edema. The interleukin (IL)-36 pathway plays a central role in the development of GPP, although several other genes may be associated. The rarity...
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Tina Bhutani Jason E Hawkes Source Type: research

In vivo Guinea Pig Model Study for Evaluating Antifungal Effect of a Dual-Diode Laser with Wavelengths of 405 Nm and 635 Nm on Dermatophytosis
CONCLUSION: The guinea pig dermatophytosis model can be used to comparatively evaluate the efficacy and safety of various treatment modalities, including dual-diode lasers, for superficial fungal skin infection.PMID:37351065 | PMC:PMC10284164 | DOI:10.2147/CCID.S415679 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 23, 2023 Category: Dermatology Authors: Jin-Chul Ahn Sang Joon Mo Min Choi Bora Kim Sung Bin Cho Source Type: research

Two Novel and a Recurrent < em > ATP2C1 < /em > Mutations in Chinese Population with Hailey-Hailey Disease
CONCLUSION: c.1402C>T mutation in the ATP2C1 gene was considered a regional highly prevalent mutation in the Chinese population with HHD. The results added new variants to the database of ATP2C1 mutations associated with HHD.PMID:37342538 | PMC:PMC10278650 | DOI:10.2147/CCID.S417792 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Deng Zhang Zhen Xiao Xiaoliang Ouyang Xiuping Wang Yunxia Zhu Simin Yu Chunming Li Source Type: research

An Unusual Case of Cutaneous Pili Migrans in a 45-Day-Old Infant
Clin Cosmet Investig Dermatol. 2023 Jun 15;16:1549-1552. doi: 10.2147/CCID.S415566. eCollection 2023.ABSTRACTCutaneous Pili Migrans (CPM), a rare skin condition, is composed of hair fragments embedded in the skin epidermis and dermis after skin trauma or for unknown reasons. To the best of our knowledge, there are few reports on cases of CPM in which hair is exposed outside of the skin. Herein, we report an unusual and rare case of 45 days old Chinese male infant with CPM.PMID:37342539 | PMC:PMC10278651 | DOI:10.2147/CCID.S415566 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Dingbin Yang Renheng Zhu Xuejun Yang Shuqiong Huang Menglu Guo Source Type: research

Transversely Sectioned Mini-Punch Grafting: A Novel Technique for Effective Treatment of Hairline Vitiligo
CONCLUSION: Our report can help to manage hairline vitiligo or hairy areas vitiligo. This method can be considered a potential method for the treatment of hairline vitiligo, thus providing a simple solution to complex problems.PMID:37342540 | PMC:PMC10278645 | DOI:10.2147/CCID.S412948 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Qiaochu Zhou Wei Wang Qi Yu Jinhui Wang Wenzheng Zhu Source Type: research

Two Novel and a Recurrent < em > ATP2C1 < /em > Mutations in Chinese Population with Hailey-Hailey Disease
CONCLUSION: c.1402C>T mutation in the ATP2C1 gene was considered a regional highly prevalent mutation in the Chinese population with HHD. The results added new variants to the database of ATP2C1 mutations associated with HHD.PMID:37342538 | PMC:PMC10278650 | DOI:10.2147/CCID.S417792 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Deng Zhang Zhen Xiao Xiaoliang Ouyang Xiuping Wang Yunxia Zhu Simin Yu Chunming Li Source Type: research

An Unusual Case of Cutaneous Pili Migrans in a 45-Day-Old Infant
Clin Cosmet Investig Dermatol. 2023 Jun 15;16:1549-1552. doi: 10.2147/CCID.S415566. eCollection 2023.ABSTRACTCutaneous Pili Migrans (CPM), a rare skin condition, is composed of hair fragments embedded in the skin epidermis and dermis after skin trauma or for unknown reasons. To the best of our knowledge, there are few reports on cases of CPM in which hair is exposed outside of the skin. Herein, we report an unusual and rare case of 45 days old Chinese male infant with CPM.PMID:37342539 | PMC:PMC10278651 | DOI:10.2147/CCID.S415566 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Dingbin Yang Renheng Zhu Xuejun Yang Shuqiong Huang Menglu Guo Source Type: research

Transversely Sectioned Mini-Punch Grafting: A Novel Technique for Effective Treatment of Hairline Vitiligo
CONCLUSION: Our report can help to manage hairline vitiligo or hairy areas vitiligo. This method can be considered a potential method for the treatment of hairline vitiligo, thus providing a simple solution to complex problems.PMID:37342540 | PMC:PMC10278645 | DOI:10.2147/CCID.S412948 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 21, 2023 Category: Dermatology Authors: Qiaochu Zhou Wei Wang Qi Yu Jinhui Wang Wenzheng Zhu Source Type: research

Post-Treatment of Micro-Needling with a Dexpanthenol-Containing Ointment Accelerates Epidermal Wound Healing in Human 3D Skin Models
CONCLUSION: Post-treatment with DCO accelerates epidermal wound healing after micro-needling of 3D skin models without impairing the immunostimulatory properties of micro-needling. These findings can help to optimise the aftercare routine after micro-needling procedures and to shorten the downtime for the patient after treatment.PMID:37337567 | PMC:PMC10276988 | DOI:10.2147/CCID.S409310 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 20, 2023 Category: Dermatology Authors: Katharina We ├čollek Yvonne Marquardt Sylvia Wagner-Schiffler Jens Malte Baron Sebastian Huth Source Type: research

Assessment and Treatment Strategies for the Aesthetic Improvement of the Lower Face and Neck
CONCLUSION: The lower face and neck are important but underrecognized areas of aesthetic concern. This article provides expert guidance and a suggested algorithm for assessment and treatment aimed at achieving satisfying and harmonious facial aesthetic results.PMID:37337568 | PMC:PMC10276991 | DOI:10.2147/CCID.S405639 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 20, 2023 Category: Dermatology Authors: Annie Chiu Vince Bertucci Daniel Dal'Asta Coimbra Dan Li Source Type: research

Identification of a Novel Mutation of Extracellular Matrix Protein 1 Gene in a Chinese Family with Lipoid Proteinosis
Clin Cosmet Investig Dermatol. 2023 Jun 14;16:1515-1519. doi: 10.2147/CCID.S415682. eCollection 2023.ABSTRACTLipoid proteinosis (LP) is a rare autosomal recessive disorder caused by mutations in extracellular matrix protein 1 (ECM1), a glycoprotein expressed in skin. Whole-exome sequencing (WES) was used to investigate two Chinese siblings with suggestive clinical features of LP. They shared one known (c.960G>A) and one novel (c.1081G>T) pathogenic variant in ECM1 gene, inherited from their unaffected parents. The novel mutation (c.1081G>T) led to a termination codon at position 361 and caused nonsense-mediated mR...
Source: Clinical, Cosmetic and Investigational Dermatology - June 20, 2023 Category: Dermatology Authors: Mengjun Xu Jiong Zhou Jianliang Yan Jianyou Wang Source Type: research