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The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson's disease
CONCLUSION: Serum pyroptosis-related ncRNAs and proteins could serve as reliable, inexpensive, and non-invasive diagnostic biomarkers for PD.LIMITATIONS: All participants were from the same region. Additionally, longitudinal studies in the aged population are required to explore the practical application value of the classifier.PMID:38172670 | PMC:PMC10765853 | DOI:10.1186/s11658-023-00516-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Junhan Liang Zhirong Wan Cheng Qian Madiha Rasheed Changling Cao Jingyan Sun Xuezhe Wang Zixuan Chen Yulin Deng Source Type: research

Correction: ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/ β-catenin signaling pathway
Cell Mol Biol Lett. 2024 Jan 3;29(1):1. doi: 10.1186/s11658-023-00527-9.NO ABSTRACTPMID:38172672 | PMC:PMC10762852 | DOI:10.1186/s11658-023-00527-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Jingjing Lu Feng Xu Yingna Zhang Hong Lu Jiewen Zhang Source Type: research

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis
CONCLUSIONS: Deacetylation of IDH1 and MDH1 reduces their activity and promotes the formation of NETs. This change aggravates the progression of acute liver failure.PMID:38172700 | PMC:PMC10765752 | DOI:10.1186/s11658-023-00529-7 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Yukun Wang Chunxia Shi Jin Guo Danmei Zhang Yanqiong Zhang Long Zhang Zuojiong Gong Source Type: research

MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription
CONCLUSION: This study finds that there is a MYCT1-MAX-RUNX1 signaling pathway in diffuse large B-cell lymphoma. And the study provides clues and basis for the in-depth studies of MYCT1 in the diagnosis, treatment and prognosis of lymphoma.PMID:38172714 | PMC:PMC10763471 | DOI:10.1186/s11658-023-00522-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Ying Liang Xin Wei Peng-Jie Yue He-Cheng Zhang Zhen-Ning Li Xiao-Xue Wang Yuan-Yuan Sun Wei-Neng Fu Source Type: research

Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin
In conclusion, tRF-Glu-CTC expression is increased after vascular injury and inhibits FMOD expression in VSMCs, which influences neointima formation. On the other hand, reducing the expression of tRF-Glu-CTC after vascular injury may be a potential approach to prevent vascular stenosis.PMID:38172726 | PMC:PMC10763295 | DOI:10.1186/s11658-023-00523-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Qi-Lan Jiang Jia-Ying Xu Qing-Ping Yao Rui Jiang Qin Xu Bo-Tao Zhang Tao Li Jun Jiang Source Type: research

The regulatory relationship between transcription factor STAT3 and noncoding RNA
Cell Mol Biol Lett. 2024 Jan 3;29(1):4. doi: 10.1186/s11658-023-00521-1.ABSTRACTSignal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance. STAT3 is considered a potential subtarget for tumor therapy. Noncoding RNA (ncRNA) is a special type of RNA transcript. Transforming from "junk" transcripts into key molecules involved in cell apoptosis, growth, and functional regulation, ncRNA has been proven to be closely related to various epithelial-mesenchym...
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Siyi Liu Wentao Li Lin Liang Yanhong Zhou Yanling Li Source Type: research

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis
CONCLUSIONS: Our research is the first to report that circPan3 has an antihypertrophic effect in cardiomyocytes and revealed a novel circPan3-modulated signalling pathway involved in cardiac hypertrophy. CircPan3 inhibits cardiac hypertrophy by targeting the miR-320-3p/HSP20 axis and is regulated by ALKBH5-mediated N6-methylation. This pathway could provide potential therapeutic targets for cardiac hypertrophy.PMID:38172650 | DOI:10.1186/s11658-023-00520-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Xinyu Fang Xiang Ao Dandan Xiao Yu Wang Yi Jia Peiyan Wang Mengyang Li Jianxun Wang Source Type: research

Oncogenic activation of EEF1A2 expression: a journey from a putative to an established oncogene
Cell Mol Biol Lett. 2024 Jan 3;29(1):6. doi: 10.1186/s11658-023-00519-9.ABSTRACTProtein synthesis via translation is a central process involving several essential proteins called translation factors. Although traditionally described as cellular "housekeepers," multiple studies have now supported that protein initiation and elongation factors regulate cell growth, apoptosis, and tumorigenesis. One such translation factor is eukaryotic elongation factor 1 alpha 2 (EEF1A2), a member of the eukaryotic elongation factor family, which has a canonical role in the delivery of aminoacyl-tRNA to the A-site of the ribosome in a guano...
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Saket Awadhesbhai Patel Md Khurshidul Hassan Manjusha Dixit Source Type: research

The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson's disease
CONCLUSION: Serum pyroptosis-related ncRNAs and proteins could serve as reliable, inexpensive, and non-invasive diagnostic biomarkers for PD.LIMITATIONS: All participants were from the same region. Additionally, longitudinal studies in the aged population are required to explore the practical application value of the classifier.PMID:38172670 | DOI:10.1186/s11658-023-00516-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Junhan Liang Zhirong Wan Cheng Qian Madiha Rasheed Changling Cao Jingyan Sun Xuezhe Wang Zixuan Chen Yulin Deng Source Type: research

Correction: ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/ β-catenin signaling pathway
Cell Mol Biol Lett. 2024 Jan 3;29(1):1. doi: 10.1186/s11658-023-00527-9.NO ABSTRACTPMID:38172672 | DOI:10.1186/s11658-023-00527-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Jingjing Lu Feng Xu Yingna Zhang Hong Lu Jiewen Zhang Source Type: research

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis
CONCLUSIONS: Deacetylation of IDH1 and MDH1 reduces their activity and promotes the formation of NETs. This change aggravates the progression of acute liver failure.PMID:38172700 | DOI:10.1186/s11658-023-00529-7 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Yukun Wang Chunxia Shi Jin Guo Danmei Zhang Yanqiong Zhang Long Zhang Zuojiong Gong Source Type: research

MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription
CONCLUSION: This study finds that there is a MYCT1-MAX-RUNX1 signaling pathway in diffuse large B-cell lymphoma. And the study provides clues and basis for the in-depth studies of MYCT1 in the diagnosis, treatment and prognosis of lymphoma.PMID:38172714 | DOI:10.1186/s11658-023-00522-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Ying Liang Xin Wei Peng-Jie Yue He-Cheng Zhang Zhen-Ning Li Xiao-Xue Wang Yuan-Yuan Sun Wei-Neng Fu Source Type: research

Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin
In conclusion, tRF-Glu-CTC expression is increased after vascular injury and inhibits FMOD expression in VSMCs, which influences neointima formation. On the other hand, reducing the expression of tRF-Glu-CTC after vascular injury may be a potential approach to prevent vascular stenosis.PMID:38172726 | DOI:10.1186/s11658-023-00523-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Qi-Lan Jiang Jia-Ying Xu Qing-Ping Yao Rui Jiang Qin Xu Bo-Tao Zhang Tao Li Jun Jiang Source Type: research

CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function
CONCLUSIONS: Our data indicate that circZNF609 is a critical regulator of fibroblast activation and silica-induced lung fibrosis. The circZNF609 and its derived peptides may represent novel promising targets for the treatment of pulmonary fibrosis.PMID:38105235 | PMC:PMC10726587 | DOI:10.1186/s11658-023-00518-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 17, 2023 Category: Biochemistry Authors: Wenqing Sun Siyun Zhou Lan Peng Yi Liu Demin Cheng Yue Wang Chunhui Ni Source Type: research