Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2'-O methylation
CONCLUSIONS: This study identified an oncofetal lncRNA MIR4435-2HG, characterized the role of MIR4435-2HG/NOP58 in stemness maintenance and proliferation of HCC cells, and confirmed m6A as a 'driver' that reactivated MR4435-2HG expression in HCC.PMID:37891494 | PMC:PMC10612268 | DOI:10.1186/s11658-023-00493-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 27, 2023 Category: Biochemistry Authors: Yiqing Zhu Bang Xiao Meng Liu Meiting Chen Ningqi Xia Haiyan Guo Jinfeng Huang Zhiyong Liu Fang Wang Source Type: research

Cellular senescence in skeletal disease: mechanisms and treatment
Cell Mol Biol Lett. 2023 Oct 27;28(1):88. doi: 10.1186/s11658-023-00501-5.ABSTRACTThe musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the balance of bone homeostasis is disrupted, leading to bone loss and degenerative diseases, such as osteoporosis, osteoarthritis, and intervertebral disc degeneration. Skeletal diseases have a profound impact on the motor and cognitive abilities of the elderly, thus creating a major challenge for both global health and the economy. Cellular senescence is caused by various genotoxic stressors and r...
Source: Cellular and Molecular Biology Letters - October 27, 2023 Category: Biochemistry Authors: Xu He Wei Hu Yuanshu Zhang Mimi Chen Yicheng Ding Huilin Yang Fan He Qiaoli Gu Qin Shi Source Type: research

Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Cell Mol Biol Lett. 2023 Oct 27;28(1):87. doi: 10.1186/s11658-023-00498-x.ABSTRACTMitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival. However, the role and mechanism of mitochondrial transfer in Cd-induced nonalcoholic fatty liver disease (NAFLD) are unclear. The present study shows that mitochondria can be transferred between hepatocytes via microtubule-dependent tunneling nanotubes. After Cd treatment, mitochondria exhibit perinuclear aggregation in hepatocytes and blocked intercellular mitochondrial transfer. The different movement directions of mito...
Source: Cellular and Molecular Biology Letters - October 26, 2023 Category: Biochemistry Authors: Jian Sun Yan Chen Tao Wang Waseem Ali Yonggang Ma Yan Yuan Jianhong Gu Jianchun Bian Zongping Liu Hui Zou Source Type: research

EFR3A: a new raft domain organizing protein?
CONCLUSIONS: Altogether, our results suggest hitherto unreported flotillin-2-EFR3A interaction, which might be responsible for membrane raft organization and regulation. This implies participation of this interaction in the regulation of multiple cellular processes, including those connected with cell signaling which points to the possible role in human health, in particular human cancer biology.PMID:37880612 | PMC:PMC10601247 | DOI:10.1186/s11658-023-00497-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 25, 2023 Category: Biochemistry Authors: Magdalena Trybus Anita Hryniewicz-Jankowska Karolina W ójtowicz Tomasz Trombik Aleksander Czogalla Aleksander F Sikorski Source Type: research

EFR3A: a new raft domain organizing protein?
CONCLUSIONS: Altogether, our results suggest hitherto unreported flotillin-2-EFR3A interaction, which might be responsible for membrane raft organization and regulation. This implies participation of this interaction in the regulation of multiple cellular processes, including those connected with cell signaling which points to the possible role in human health, in particular human cancer biology.PMID:37880612 | DOI:10.1186/s11658-023-00497-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 25, 2023 Category: Biochemistry Authors: Magdalena Trybus Anita Hryniewicz-Jankowska Karolina W ójtowicz Tomasz Trombik Aleksander Czogalla Aleksander F Sikorski Source Type: research