Cellular and Molecular Biology Letters 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma
CONCLUSION: These findings establish a preclinical foundation for the combined use of an anti-HER2 drug conjugate and a BRAF inhibitor in the treatment of BRAF-mutant cutaneous melanoma.PMID:38594618 | PMC:PMC11005275 | DOI:10.1186/s11658-024-00555-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Weisong Li Chao Zheng Xi Xu Yujie Xia Kai Zhang Ao Huang Xinyu Zhang Yong Zheng Guofang Chen Shuyong Zhang Source Type: research
Correction: A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Cell Mol Biol Lett. 2024 Apr 9;29(1):49. doi: 10.1186/s11658-024-00567-9.NO ABSTRACTPMID:38594613 | DOI:10.1186/s11658-024-00567-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research
Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma
CONCLUSION: These findings establish a preclinical foundation for the combined use of an anti-HER2 drug conjugate and a BRAF inhibitor in the treatment of BRAF-mutant cutaneous melanoma.PMID:38594618 | DOI:10.1186/s11658-024-00555-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 9, 2024 Category: Biochemistry Authors: Weisong Li Chao Zheng Xi Xu Yujie Xia Kai Zhang Ao Huang Xinyu Zhang Yong Zheng Guofang Chen Shuyong Zhang Source Type: research
Escaping from CRISPR-Cas-mediated knockout: the facts, mechanisms, and applications
Cell Mol Biol Lett. 2024 Apr 8;29(1):48. doi: 10.1186/s11658-024-00565-x.ABSTRACTClustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR-Cas), a powerful genome editing tool, has revolutionized gene function investigation and exhibits huge potential for clinical applications. CRISPR-Cas-mediated gene knockout has already become a routine method in research laboratories. However, in the last few years, accumulating evidences have demonstrated that genes knocked out by CRISPR-Cas may not be truly silenced. Functional residual proteins could be generated in such knockout organisms to compe...
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ying Wang Yujing Zhai Mingzhe Zhang Chunlin Song Yuqing Zhang Gang Zhang Source Type: research
G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1-Bax-mediated mitochondrial apoptosis pathway
CONCLUSION: Our study showed that the G6PD-VDAC1-Bax axis is a vital switch in VSMC apoptosis and is essential for VSMC phenotypic switching and neointimal hyperplasia, providing mechanistic insight into early VRDs.PMID:38589823 | PMC:PMC11003121 | DOI:10.1186/s11658-024-00566-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ting Zhang Rui-Jie Cao Jiang-Ling Niu Zhi-Huan Chen Shi-Qing Mu Tong Cao Jie-Xin Pang Li-Hua Dong Source Type: research
Escaping from CRISPR-Cas-mediated knockout: the facts, mechanisms, and applications
Cell Mol Biol Lett. 2024 Apr 8;29(1):48. doi: 10.1186/s11658-024-00565-x.ABSTRACTClustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR-Cas), a powerful genome editing tool, has revolutionized gene function investigation and exhibits huge potential for clinical applications. CRISPR-Cas-mediated gene knockout has already become a routine method in research laboratories. However, in the last few years, accumulating evidences have demonstrated that genes knocked out by CRISPR-Cas may not be truly silenced. Functional residual proteins could be generated in such knockout organisms to compe...
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ying Wang Yujing Zhai Mingzhe Zhang Chunlin Song Yuqing Zhang Gang Zhang Source Type: research
G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1-Bax-mediated mitochondrial apoptosis pathway
CONCLUSION: Our study showed that the G6PD-VDAC1-Bax axis is a vital switch in VSMC apoptosis and is essential for VSMC phenotypic switching and neointimal hyperplasia, providing mechanistic insight into early VRDs.PMID:38589823 | DOI:10.1186/s11658-024-00566-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 8, 2024 Category: Biochemistry Authors: Ting Zhang Rui-Jie Cao Jiang-Ling Niu Zhi-Huan Chen Shi-Qing Mu Tong Cao Jie-Xin Pang Li-Hua Dong Source Type: research
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
CONCLUSIONS: Taken together, our findings indicate important functional roles of sialic acids in sEV uptake and reprogramming plasticity of surrounding normal epithelial cells.PMID:38561669 | PMC:PMC10983696 | DOI:10.1186/s11658-024-00562-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 2, 2024 Category: Biochemistry Authors: Meixuan Lin Xiaoqiang Xu Xiaoman Zhou Hui Feng Ruili Wang Yunyun Yang Jing Li Ning Fan Yazhuo Jiang Xiang Li Feng Guan Zengqi Tan Source Type: research
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
CONCLUSIONS: Taken together, our findings indicate important functional roles of sialic acids in sEV uptake and reprogramming plasticity of surrounding normal epithelial cells.PMID:38561669 | PMC:PMC10983696 | DOI:10.1186/s11658-024-00562-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 2, 2024 Category: Biochemistry Authors: Meixuan Lin Xiaoqiang Xu Xiaoman Zhou Hui Feng Ruili Wang Yunyun Yang Jing Li Ning Fan Yazhuo Jiang Xiang Li Feng Guan Zengqi Tan Source Type: research
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
CONCLUSIONS: Taken together, our findings indicate important functional roles of sialic acids in sEV uptake and reprogramming plasticity of surrounding normal epithelial cells.PMID:38561669 | PMC:PMC10983696 | DOI:10.1186/s11658-024-00562-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 2, 2024 Category: Biochemistry Authors: Meixuan Lin Xiaoqiang Xu Xiaoman Zhou Hui Feng Ruili Wang Yunyun Yang Jing Li Ning Fan Yazhuo Jiang Xiang Li Feng Guan Zengqi Tan Source Type: research
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
CONCLUSIONS: Taken together, our findings indicate important functional roles of sialic acids in sEV uptake and reprogramming plasticity of surrounding normal epithelial cells.PMID:38561669 | PMC:PMC10983696 | DOI:10.1186/s11658-024-00562-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 2, 2024 Category: Biochemistry Authors: Meixuan Lin Xiaoqiang Xu Xiaoman Zhou Hui Feng Ruili Wang Yunyun Yang Jing Li Ning Fan Yazhuo Jiang Xiang Li Feng Guan Zengqi Tan Source Type: research
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
CONCLUSIONS: Taken together, our findings indicate important functional roles of sialic acids in sEV uptake and reprogramming plasticity of surrounding normal epithelial cells.PMID:38561669 | DOI:10.1186/s11658-024-00562-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 2, 2024 Category: Biochemistry Authors: Meixuan Lin Xiaoqiang Xu Xiaoman Zhou Hui Feng Ruili Wang Yunyun Yang Jing Li Ning Fan Yazhuo Jiang Xiang Li Feng Guan Zengqi Tan Source Type: research
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
CONCLUSIONS: Mifepristone alone is capable of inducing adipocyte differentiation in 3T3-L1 cells and adipogenesis in vivo. PPARγ plays a critical role in the mifepristone-induced adipocyte differentiation. Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.PMID:38553665 | PMC:PMC10981365 | DOI:10.1186/s11658-024-00559-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 30, 2024 Category: Biochemistry Authors: Takeshi Hashimoto Katsuya Hirano Source Type: research
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
Cell Mol Biol Lett. 2024 Mar 29;29(1):44. doi: 10.1186/s11658-024-00563-z.ABSTRACTAspartate-glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate and is part of the malate-aspartate shuttle, essential for the balance of reducing equivalents in the cells. In the brain, mutations in SLC25A12 gene, encoding for AGC1, cause an ultra-rare genetic disease, reported as a neurodevelopmental encephalopathy, whose symptoms include global hypomyelination, arrested psychomotor development, hypotonia and seizures. Among the biological components most af...
Source: Cellular and Molecular Biology Letters - March 30, 2024 Category: Biochemistry Authors: Nicola Balboni Giorgia Babini Eleonora Poeta Michele Protti Laura Mercolini Maria Chiara Magnifico Simona Nicole Barile Francesca Massenzio Antonella Pignataro Federico M Giorgi Francesco Massimo Lasorsa Barbara Monti Source Type: research
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
CONCLUSIONS: Mifepristone alone is capable of inducing adipocyte differentiation in 3T3-L1 cells and adipogenesis in vivo. PPARγ plays a critical role in the mifepristone-induced adipocyte differentiation. Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.PMID:38553665 | PMC:PMC10981365 | DOI:10.1186/s11658-024-00559-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 30, 2024 Category: Biochemistry Authors: Takeshi Hashimoto Katsuya Hirano Source Type: research
