Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Correction: ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity
Cell Mol Biol Lett. 2024 Jan 18;29(1):16. doi: 10.1186/s11658-024-00534-4.NO ABSTRACTPMID:38238691 | PMC:PMC10797865 | DOI:10.1186/s11658-024-00534-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 18, 2024 Category: Biochemistry Authors: Zhonglin Cai Yao Zhang Lin Yang Chunhui Ma Yi Fei Jing Ding Wei Song Wei-Min Tong Yamei Niu Hongjun Li Source Type: research

SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
CONCLUSIONS: SUMO2 conjugation to eIF5A is a stress-induced response implicated in the adaptation of yeast cells to heat-shock stress and required to promote the growth and migration of pancreatic ductal adenocarcinoma cells.PMID:38229033 | PMC:PMC10790418 | DOI:10.1186/s11658-024-00533-5 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 16, 2024 Category: Biochemistry Authors: Roc ío Seoane Tom ás Lama-Díaz Antonia Mar ía Romero Ahmed El Motiam Arantxa Mart ínez-Férriz Santiago Vidal Yanis H Bouzaher Mar ía Blanquer Roc ío M Tolosa Juan Castillo Mewa Manuel S Rodr íguez Adolfo Garc ía-Sastre Dimitris Xirodimas James D Source Type: research

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review
Cell Mol Biol Lett. 2024 Jan 16;29(1):14. doi: 10.1186/s11658-024-00531-7.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration and worsening symptoms. Adenosine deaminase (ADA), an enzyme in purine metabolism, influences adenosine levels and joint inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases in hypoxic and inflammatory conditions. Lymphocytes with ADA play a role in RA. Inhibiting lymphocytic ADA activity has an immune-regulatory effect. Synovial fluid levels of...
Source: Cellular and Molecular Biology Letters - January 15, 2024 Category: Biochemistry Authors: Amira Atta Maha M Salem Karim Samy El-Said Tarek M Mohamed Source Type: research

Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
Cell Mol Biol Lett. 2024 Jan 16;29(1):13. doi: 10.1186/s11658-023-00528-8.ABSTRACTTRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains. These proteins are efficient regulators of autophagy, apoptosis, and innate immune responses and confer immunity against viruses and bacteria. TRIMs function as receptors or scaffold proteins that target substrates for autophagy-mediated degradation. Most TRIMs interact with the BECN1-ULK1 complex to form TRIMosomes, thereby efficiently targeting substrates to autophagosomes. They regulate the functions of ATG proteins through physical interact...
Source: Cellular and Molecular Biology Letters - January 15, 2024 Category: Biochemistry Authors: Nuzhat Ahsan Mohd Shariq Avadhesha Surolia Reshmi Raj Mohammad Firoz Khan Pramod Kumar Source Type: research

Increased serum extrachromosomal circular DNA SORBS1 < sup > circle < /sup > level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus
CONCLUSIONS: These results provide a preliminary understanding of the circulating eccDNA patterns at the early stage of T2DM and suggest that eccDNA SORBS1circle may be involved in the development of insulin resistance.PMID:38212723 | PMC:PMC10785328 | DOI:10.1186/s11658-023-00530-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 11, 2024 Category: Biochemistry Authors: Xiang Kong Shu-Jun Wan Tian-Bing Chen Lan Jiang Yu-Jie Xing Ya-Ping Bai Qiang Hua Xin-Ming Yao Yong-Li Zhao Hong-Mei Zhang De-Guo Wang Qing Su Kun Lv Source Type: research

Retraction Note: Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice
Cell Mol Biol Lett. 2024 Jan 8;29(1):11. doi: 10.1186/s11658-023-00524-y.NO ABSTRACTPMID:38191329 | PMC:PMC10775655 | DOI:10.1186/s11658-023-00524-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 8, 2024 Category: Biochemistry Authors: Guangzhe Yu Qian Liu Xuening Dong Kaihong Tang Bohui Li Chunmei Liu Wenzheng Zhang Yiduo Wang Yingyu Jin Source Type: research

The efficacy of adipose-derived stem cells in burn injuries: a systematic review
CONCLUSION: In conclusion, it appears that adipose-derived stem cells demonstrate remarkable efficacy in the field of regenerative medicine. However, the usage of ADSCs in the treatment of burns is still at an early experimental stage, and further investigations are required in order to examine the potential usage of ADSCs in future clinical burn care.PMID:38182971 | PMC:PMC10771009 | DOI:10.1186/s11658-023-00526-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 5, 2024 Category: Biochemistry Authors: Michael Kohlhauser Alexandru Tuca Lars-Peter Kamolz Source Type: research

MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken
CONCLUSIONS: Our results reveal a new pattern of the regulation of lncRNA expression at diverse levels and help expound the regulation of m6A methylation on chromatin status.PMID:38177995 | PMC:PMC10765903 | DOI:10.1186/s11658-023-00525-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 4, 2024 Category: Biochemistry Authors: Bolin Cai Manting Ma Rongshuai Yuan Zhen Zhou Jing Zhang Shaofen Kong Duo Lin Ling Lian Juan Li Xiquan Zhang Qinghua Nie Source Type: research

The regulatory relationship between transcription factor STAT3 and noncoding RNA
Cell Mol Biol Lett. 2024 Jan 3;29(1):4. doi: 10.1186/s11658-023-00521-1.ABSTRACTSignal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance. STAT3 is considered a potential subtarget for tumor therapy. Noncoding RNA (ncRNA) is a special type of RNA transcript. Transforming from "junk" transcripts into key molecules involved in cell apoptosis, growth, and functional regulation, ncRNA has been proven to be closely related to various epithelial-mesenchym...
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Siyi Liu Wentao Li Lin Liang Yanhong Zhou Yanling Li Source Type: research

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis
CONCLUSIONS: Our research is the first to report that circPan3 has an antihypertrophic effect in cardiomyocytes and revealed a novel circPan3-modulated signalling pathway involved in cardiac hypertrophy. CircPan3 inhibits cardiac hypertrophy by targeting the miR-320-3p/HSP20 axis and is regulated by ALKBH5-mediated N6-methylation. This pathway could provide potential therapeutic targets for cardiac hypertrophy.PMID:38172650 | PMC:PMC10763352 | DOI:10.1186/s11658-023-00520-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Xinyu Fang Xiang Ao Dandan Xiao Yu Wang Yi Jia Peiyan Wang Mengyang Li Jianxun Wang Source Type: research

Oncogenic activation of EEF1A2 expression: a journey from a putative to an established oncogene
Cell Mol Biol Lett. 2024 Jan 3;29(1):6. doi: 10.1186/s11658-023-00519-9.ABSTRACTProtein synthesis via translation is a central process involving several essential proteins called translation factors. Although traditionally described as cellular "housekeepers," multiple studies have now supported that protein initiation and elongation factors regulate cell growth, apoptosis, and tumorigenesis. One such translation factor is eukaryotic elongation factor 1 alpha 2 (EEF1A2), a member of the eukaryotic elongation factor family, which has a canonical role in the delivery of aminoacyl-tRNA to the A-site of the ribosome in a guano...
Source: Cellular and Molecular Biology Letters - January 3, 2024 Category: Biochemistry Authors: Saket Awadhesbhai Patel Md Khurshidul Hassan Manjusha Dixit Source Type: research