MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | PMC:PMC10571261 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | PMC:PMC10571419 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research

MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | PMC:PMC10571261 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | PMC:PMC10571419 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research

MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | PMC:PMC10571261 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | PMC:PMC10571419 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research

MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | PMC:PMC10571261 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | PMC:PMC10571419 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research

MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research