Cellular and Molecular Biology Letters 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
CONCLUSION: As a result, we found that varicocele-induced oxidative stress promoted PLOD2 expression level via m6A methylation modification. In addition, targeting m6A demethylation of PLOD2 by CRISPR/dCas13b-ALKBH5 system can regulate GC-2 cell proliferation and apoptosis under oxidative stress. Taken together, our study has acquired a better understanding of the mechanisms underlying male infertility associated with oxidative stress, as well as a novel therapeutic target for male infertility.PMID:37670228 | PMC:PMC10481479 | DOI:10.1186/s11658-023-00475-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 5, 2023 Category: Biochemistry Authors: Huan Li Jun Zhao Hao Deng YuCheng Zhong Mian Chen LinSheng Chi GuoQun Luo Cong Cao Cong Yu Honghai Liu Xinzong Zhang Source Type: research
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
CONCLUSION: As a result, we found that varicocele-induced oxidative stress promoted PLOD2 expression level via m6A methylation modification. In addition, targeting m6A demethylation of PLOD2 by CRISPR/dCas13b-ALKBH5 system can regulate GC-2 cell proliferation and apoptosis under oxidative stress. Taken together, our study has acquired a better understanding of the mechanisms underlying male infertility associated with oxidative stress, as well as a novel therapeutic target for male infertility.PMID:37670228 | DOI:10.1186/s11658-023-00475-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 5, 2023 Category: Biochemistry Authors: Huan Li Jun Zhao Hao Deng YuCheng Zhong Mian Chen LinSheng Chi GuoQun Luo Cong Cao Cong Yu Honghai Liu Xinzong Zhang Source Type: research
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
In this study, UGCG was induced in response to pressure overload in vivo and phenylephrine stimulation in vitro. Additionally, UGCG downregulation ameliorated cardiomyocyte hypertrophy, improved cardiomyocyte mitochondrial oxidative stress, and reduced the ERK signaling pathway. Conversely, UGCG overexpression in cardiomyocytes promoted heart hypertrophy development, aggravated mitochondrial oxidative stress, and stimulated ERK signaling. Furthermore, the interaction between beta-1,4-galactosyltransferase 5 (B4GalT5), which catalyses the synthesis of lactosylceramide, and UGCG was identified, which also functions as a syne...
Source: Cellular and Molecular Biology Letters - September 1, 2023 Category: Biochemistry Authors: Shengyu Cui Xutao Zhang Yuhua Li Shan Hu Bing Wu Zhao Fang Jixian Gao Ming Li Haoliang Wu Bo Tao Hao Xia Lin Xu Source Type: research
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
In this study, UGCG was induced in response to pressure overload in vivo and phenylephrine stimulation in vitro. Additionally, UGCG downregulation ameliorated cardiomyocyte hypertrophy, improved cardiomyocyte mitochondrial oxidative stress, and reduced the ERK signaling pathway. Conversely, UGCG overexpression in cardiomyocytes promoted heart hypertrophy development, aggravated mitochondrial oxidative stress, and stimulated ERK signaling. Furthermore, the interaction between beta-1,4-galactosyltransferase 5 (B4GalT5), which catalyses the synthesis of lactosylceramide, and UGCG was identified, which also functions as a syne...
Source: Cellular and Molecular Biology Letters - September 1, 2023 Category: Biochemistry Authors: Shengyu Cui Xutao Zhang Yuhua Li Shan Hu Bing Wu Zhao Fang Jixian Gao Ming Li Haoliang Wu Bo Tao Hao Xia Lin Xu Source Type: research
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
In this study, UGCG was induced in response to pressure overload in vivo and phenylephrine stimulation in vitro. Additionally, UGCG downregulation ameliorated cardiomyocyte hypertrophy, improved cardiomyocyte mitochondrial oxidative stress, and reduced the ERK signaling pathway. Conversely, UGCG overexpression in cardiomyocytes promoted heart hypertrophy development, aggravated mitochondrial oxidative stress, and stimulated ERK signaling. Furthermore, the interaction between beta-1,4-galactosyltransferase 5 (B4GalT5), which catalyses the synthesis of lactosylceramide, and UGCG was identified, which also functions as a syne...
Source: Cellular and Molecular Biology Letters - September 1, 2023 Category: Biochemistry Authors: Shengyu Cui Xutao Zhang Yuhua Li Shan Hu Bing Wu Zhao Fang Jixian Gao Ming Li Haoliang Wu Bo Tao Hao Xia Lin Xu Source Type: research
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
In this study, UGCG was induced in response to pressure overload in vivo and phenylephrine stimulation in vitro. Additionally, UGCG downregulation ameliorated cardiomyocyte hypertrophy, improved cardiomyocyte mitochondrial oxidative stress, and reduced the ERK signaling pathway. Conversely, UGCG overexpression in cardiomyocytes promoted heart hypertrophy development, aggravated mitochondrial oxidative stress, and stimulated ERK signaling. Furthermore, the interaction between beta-1,4-galactosyltransferase 5 (B4GalT5), which catalyses the synthesis of lactosylceramide, and UGCG was identified, which also functions as a syne...
Source: Cellular and Molecular Biology Letters - September 1, 2023 Category: Biochemistry Authors: Shengyu Cui Xutao Zhang Yuhua Li Shan Hu Bing Wu Zhao Fang Jixian Gao Ming Li Haoliang Wu Bo Tao Hao Xia Lin Xu Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
This study aimed to investigate the role and mechanism of the serine protease GZMA in osteoclasts during chronic apical periodontitis. To address this, we employed crRNA/Cas13d to inhibit GZMA expression and examined its impact on osteoclast behavior. Our findings revealed that GZMA plays a significant role in promoting osteoclast cell proliferation while inhibiting cell apoptosis. Additionally, the inhibition of GZMA led to a notable increase in miR-25-3p expression, which, in turn, downregulated the expression of TGF-β. Consequently, the reduction in TGF-β expression led to a decrease in PAR1 expression within the PARs...
Source: Cellular and Molecular Biology Letters - August 25, 2023 Category: Biochemistry Authors: Tingting Jia Fang Yuan Jingqiao Tao Gang Wang Xianhua Zhang Bin Zhang Hongbo Li Source Type: research
Correction: Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway
Cell Mol Biol Lett. 2023 Aug 24;28(1):69. doi: 10.1186/s11658-023-00478-1.NO ABSTRACTPMID:37620770 | DOI:10.1186/s11658-023-00478-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 24, 2023 Category: Biochemistry Authors: Yanchun Li Bing Xu Xueying Ren Luyang Wang Yaqing Xu Yefeng Zhao Chen Yang Chen Yuan Huanjuan Li Xiangmin Tong Ying Wang Jing Du Source Type: research
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
CONCLUSIONS: Our systems biology data indicate that DSC1 is connected to mechanisms of cell cycle regulation in luminal A breast cancer cells, and can be effectively modulated by parthenolide.PMID:37620794 | DOI:10.1186/s11658-023-00481-6 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 24, 2023 Category: Biochemistry Authors: Petr Lapcik Petr Sulc Lucia Janacova Katerina Jilkova David Potesil Pavla Bouchalova Petr M üller Pavel Bouchal Source Type: research
Correction: Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62-Keap1-NRF2 pathway
Cell Mol Biol Lett. 2023 Aug 24;28(1):69. doi: 10.1186/s11658-023-00478-1.NO ABSTRACTPMID:37620770 | DOI:10.1186/s11658-023-00478-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - August 24, 2023 Category: Biochemistry Authors: Yanchun Li Bing Xu Xueying Ren Luyang Wang Yaqing Xu Yefeng Zhao Chen Yang Chen Yuan Huanjuan Li Xiangmin Tong Ying Wang Jing Du Source Type: research
