Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Cell Mol Biol Lett. 2023 Dec 11;28(1):103. doi: 10.1186/s11658-023-00514-0.ABSTRACTGlioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM malignancy may have prognostic values in predicting survival outcomes and therapeutic responses, especially in patients with high-grade gliomas. In particular, N6-methyladenine (m6A) mRNA modification is the most abundant form of post-transcriptional RNA m...
Source: Cellular and Molecular Biology Letters - December 10, 2023 Category: Biochemistry Authors: Chunlin Li Bowen Li Hui Wang Linglong Qu Hui Liu Chao Weng Jinming Han Yuan Li Source Type: research

Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
CONCLUSIONS: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung stem cell regeneration.PMID:38066447 | PMC:PMC10709870 | DOI:10.1186/s11658-023-00488-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 9, 2023 Category: Biochemistry Authors: Juan Song Miao Li Cuicui Chen Jian Zhou Linlin Wang Yu Yan Jun She Lin Tong Yuanlin Song Source Type: research

Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
CONCLUSIONS: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung stem cell regeneration.PMID:38066447 | DOI:10.1186/s11658-023-00488-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 9, 2023 Category: Biochemistry Authors: Juan Song Miao Li Cuicui Chen Jian Zhou Linlin Wang Yu Yan Jun She Lin Tong Yuanlin Song Source Type: research

METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
CONCLUSIONS: Our results revealed a novel m6A-modified circRNA3634 promoted the proliferation and differentiation of antler chondrocytes by regulating MAPK1. The nuclear export of circRNA3634 was related to the expression of YTHDC1.PMID:38062349 | PMC:PMC10702069 | DOI:10.1186/s11658-023-00515-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 7, 2023 Category: Biochemistry Authors: Mengmeng Song Haibo Yao Zitong Sun Danyang Chen Xiwen Xu Guohui Long Lei Wu Wei Hu Source Type: research

METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
CONCLUSIONS: Our results revealed a novel m6A-modified circRNA3634 promoted the proliferation and differentiation of antler chondrocytes by regulating MAPK1. The nuclear export of circRNA3634 was related to the expression of YTHDC1.PMID:38062349 | DOI:10.1186/s11658-023-00515-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 7, 2023 Category: Biochemistry Authors: Mengmeng Song Haibo Yao Zitong Sun Danyang Chen Xiwen Xu Guohui Long Lei Wu Wei Hu Source Type: research

Metabolite itaconate in host immunoregulation and defense
Cell Mol Biol Lett. 2023 Dec 2;28(1):100. doi: 10.1186/s11658-023-00503-3.ABSTRACTMetabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively modulate the host immune response. Itaconate, an intermediate metabolite derived from the tricarboxylic acid (TCA) cycle of immune cells, is produced through the decarboxylation of cis-aconitate by cis-aconitate decarboxylase in the mitochondria. The gene encoding cis-aconitate decarboxylase is known as immune response gene 1 (IRG1). In response to external proinflammatory stimulation, macrophages exhib...
Source: Cellular and Molecular Biology Letters - December 2, 2023 Category: Biochemistry Authors: Wenchang Yang Yaxin Wang Kaixiong Tao Ruidong Li Source Type: research

Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
CONCLUSIONS: We reviewed 219 previous publications and conducted the first bibliometric study of CRISPR technology related to extracellular vesicles from 2015 to 2022. This comprehensive summary constructed a knowledge map and demonstrates the trends in this area. The current trends and potential hotpots for this topic are also identified, which will be a great help for researchers in the future.PMID:38041049 | PMC:PMC10693129 | DOI:10.1186/s11658-023-00507-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 1, 2023 Category: Biochemistry Authors: Jianjing Lin Shicheng Jia Zilu Jiao Jiayou Chen Wei Li Fuyang Cao Xintao Zhang Source Type: research

Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
CONCLUSIONS: We reviewed 219 previous publications and conducted the first bibliometric study of CRISPR technology related to extracellular vesicles from 2015 to 2022. This comprehensive summary constructed a knowledge map and demonstrates the trends in this area. The current trends and potential hotpots for this topic are also identified, which will be a great help for researchers in the future.PMID:38041049 | DOI:10.1186/s11658-023-00507-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - December 1, 2023 Category: Biochemistry Authors: Jianjing Lin Shicheng Jia Zilu Jiao Jiayou Chen Wei Li Fuyang Cao Xintao Zhang Source Type: research

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
This study provides a potentially effective anti-cancer strategy for gene therapy of prostate cancer.PMID:38017385 | PMC:PMC10685504 | DOI:10.1186/s11658-023-00508-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Yi Yang Hongbing Mei Xiaohong Han Xintao Zhang Jianli Cheng Zhongfu Zhang Han Wang Haixia Xu Source Type: research

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Cell Mol Biol Lett. 2023 Nov 29;28(1):97. doi: 10.1186/s11658-023-00511-3.ABSTRACTArachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 gene is structurally similar to the orthologous genes of other mammals. However, mouse and human ALOX15 orthologs have different functional characteristics. Human ALOX15 converts C20 polyenoic fatty acids like arachidonic acid mainly to the n-6 hydroperoxide. In contrast, the n-9 hydroperoxide is the major o...
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Florian Reisch Dagmar Heydeck Marjann Sch äfer Michael Rothe Jiaxing Yang Sabine Stehling Gerhard P P üschel Hartmut Kuhn Source Type: research