Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

High-content image screening to identify chemical modulators for peroxisome and ferroptosis
CONCLUSIONS: Our findings pinpoint novel cellular targets that might be involved in peroxisome homeostasis and indicate that compounds promoting peroxisomal abundance could be jointly applied with ferroptosis inducers to potentiate anticancer effect.PMID:38368371 | PMC:PMC10874541 | DOI:10.1186/s11658-024-00544-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 17, 2024 Category: Biochemistry Authors: Daheng Zheng Fei Li Shanshan Wang Pu-Ste Liu Xin Xie Source Type: research

High-content image screening to identify chemical modulators for peroxisome and ferroptosis
CONCLUSIONS: Our findings pinpoint novel cellular targets that might be involved in peroxisome homeostasis and indicate that compounds promoting peroxisomal abundance could be jointly applied with ferroptosis inducers to potentiate anticancer effect.PMID:38368371 | DOI:10.1186/s11658-024-00544-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 17, 2024 Category: Biochemistry Authors: Daheng Zheng Fei Li Shanshan Wang Pu-Ste Liu Xin Xie Source Type: research

CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
CONCLUSIONS: CircMAST1 plays a major suppressive role in the tumor growth and metastasis of CCa. In particular, circMAST1 can serve as a potential biomarker and novel target for CCa.PMID:38331765 | PMC:PMC10854152 | DOI:10.1186/s11658-024-00540-6 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 8, 2024 Category: Biochemistry Authors: Chunyu Zhang Li Yuan Qiaojian Zou Caixia Shao Yan Jia Jiaying Li Yan Liao Xueyuan Zhao Weijia Wen Xu Jing Guofen Yang Wei Wang Hongye Jiang Shuzhong Yao Source Type: research

The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds
CONCLUSIONS: AW1 modulates inflammation and the wound healing process by the TLR4/NF-κB molecular axis, thus facilitating reepithelialization, granulation regeneration, and angiogenesis. These findings not only provided a promising multifunctional prohealing drug candidate for chronic nonhealing skin wounds but also highlighted the unique roles of "small" peptides in the elucidation of "big" human disease mechanisms.PMID:38317065 | PMC:PMC10845795 | DOI:10.1186/s11658-024-00542-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 5, 2024 Category: Biochemistry Authors: Chao Li Yuxin Xiong Zhe Fu Yuxin Ji Jiayi Yan Yan Kong Ying Peng Zeqiong Ru Yubing Huang Yilin Li Ying Yang Li He Jing Tang Ying Wang Xinwang Yang Source Type: research

Ubiquitous protein lactylation in health and diseases
Cell Mol Biol Lett. 2024 Feb 5;29(1):23. doi: 10.1186/s11658-024-00541-5.ABSTRACTFor decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism but also cellular communications, which can transcend compartment barriers and can occur within and among different cells, tissues and organs. Recently, the discovery that lactate can induce a novel post-translational modification, named lysine lactylation (Kla), brings forth a new avenue to study nonmetabolic functions for lactate, whic...
Source: Cellular and Molecular Biology Letters - February 5, 2024 Category: Biochemistry Authors: Junyong Wang Ziyi Wang Qixu Wang Xiao Li Yaping Guo Source Type: research

IP < sub > 3 < /sub > R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin
CONCLUSION: Melatonin prevents the formation of MAMs via the MR-ERK1/2-FoxO1-IP3R1 pathway, thereby alleviating the development of MT-induced liver injury. Melatonin-modulated MAMs may be a promising therapeutic therapy for traumatic hepatic injury.PMID:38308199 | PMC:PMC10836028 | DOI:10.1186/s11658-023-00509-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - February 2, 2024 Category: Biochemistry Authors: Rui Shi Zhenhua Liu Huan Yue Man Li Simin Liu Dema De Runjing Li Yunan Chen Shuli Cheng Xiaoming Gu Min Jia Jun Li Juan Li Shumiao Zhang Na Feng Rong Fan Feng Fu Yali Liu Mingge Ding Jianming Pei Source Type: research

New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation
CONCLUSIONS: This study presents a comprehensive mitochondrial metabolism and immune infiltration landscape in SCM, providing a potential novel direction for the pathogenesis and medical intervention of SCM.PMID:38291374 | PMC:PMC10826082 | DOI:10.1186/s11658-024-00536-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 30, 2024 Category: Biochemistry Authors: Yukun Li Jiachi Yu Ruibing Li Hao Zhou Xing Chang Source Type: research

Role of microRNA-4739 in enhancing cisplatin chemosensitivity by negative regulation of RHBDD2 in human cervical cancer cells
CONCLUSIONS: In summary, our study revealed that miR-4739 can reverse DDP resistance by modulating RHBDD2 in CC cells.PMID:38267862 | PMC:PMC10809578 | DOI:10.1186/s11658-024-00532-6 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 24, 2024 Category: Biochemistry Authors: Yuling Li Zhengtong Zhou Jinfeng Qu Peiling Gong Yuyan Wei Yaping Sun Source Type: research

Regulation of tumor metastasis and CD8 < sup > + < /sup > T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer
CONCLUSIONS: Here, we provide novel mechanistic insight revealing how circRNF216 functioned in CRC metastasis and TIME via the circRNF216/miR-576-5p/ZC3H12C pathway. Therefore, circRNF216 holds promise as a potential therapeutic target and novel diagnostic marker for CRC.PMID:38267865 | PMC:PMC10809481 | DOI:10.1186/s11658-024-00539-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 24, 2024 Category: Biochemistry Authors: Wenqi Du Xin Quan Chaoqun Wang Qiuya Song Jie Mou Dongsheng Pei Source Type: research

Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium
CONCLUSIONS: Pro-inflammatory cytokines enhance CFTR-dependent anion secretion across pancreatic ductal epithelium. We propose that up-regulation of CFTR in the early stages of the inflammatory response, may serve to promote the removal of pathogenic stimuli from the ductal tree, and limit tissue injury.PMID:38262945 | PMC:PMC10807165 | DOI:10.1186/s11658-024-00537-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 23, 2024 Category: Biochemistry Authors: Dora Angyal Tessa A Groeneweg Anny Leung Max Desain Kalyan Dulla Hugo R de Jonge Marcel J C Bijvelds Source Type: research

FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism
The objective of this study is to ascertain whether a correlation exists between FFAR4, which functions as the primary receptor for dietary fatty acids, and various characteristics of LUAD, while also delving into the potential underlying mechanism. The findings of this study indicate a decrease in FFAR4 expression in LUAD, with a positive correlation (P < 0.01) between FFAR4 levels and overall patient survival (OS). Receiver operating characteristic (ROC) curve analysis demonstrated a significant diagnostic value [area under the curve (AUC) of 0.933] associated with FFAR4 expression. Functional investigations revealed ...
Source: Cellular and Molecular Biology Letters - January 19, 2024 Category: Biochemistry Authors: Zhe Wang Jinyou Li LongFei Wang Yaowei Liu Wei Wang JiaYao Chen HuiJun Liang Y Q Chen ShengLong Zhu Source Type: research

Correction: ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity
Cell Mol Biol Lett. 2024 Jan 18;29(1):16. doi: 10.1186/s11658-024-00534-4.NO ABSTRACTPMID:38238691 | PMC:PMC10797865 | DOI:10.1186/s11658-024-00534-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 18, 2024 Category: Biochemistry Authors: Zhonglin Cai Yao Zhang Lin Yang Chunhui Ma Yi Fei Jing Ding Wei Song Wei-Min Tong Yamei Niu Hongjun Li Source Type: research

SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
CONCLUSIONS: SUMO2 conjugation to eIF5A is a stress-induced response implicated in the adaptation of yeast cells to heat-shock stress and required to promote the growth and migration of pancreatic ductal adenocarcinoma cells.PMID:38229033 | PMC:PMC10790418 | DOI:10.1186/s11658-024-00533-5 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - January 16, 2024 Category: Biochemistry Authors: Roc ío Seoane Tom ás Lama-Díaz Antonia Mar ía Romero Ahmed El Motiam Arantxa Mart ínez-Férriz Santiago Vidal Yanis H Bouzaher Mar ía Blanquer Roc ío M Tolosa Juan Castillo Mewa Manuel S Rodr íguez Adolfo Garc ía-Sastre Dimitris Xirodimas James D Source Type: research