Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
CONCLUSIONS: The aforementioned results indicate that exosomal miR-155-5p drives widespread macrophage inflammation and M1 polarization in hvKp-induced ALI through the MSK1/p38-MAPK Axis.PMID:37953267 | PMC:PMC10641976 | DOI:10.1186/s11658-023-00505-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 12, 2023 Category: Biochemistry Authors: Yihan Xu Chunying Zhang Danni Cai Rongping Zhu Yingping Cao Source Type: research

Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
CONCLUSIONS: Irf7 transcriptionally activates the expression of Srg3, which can promote ferroptosis and activate classical activation phenotype (M1) macrophage polarization by regulating the NF-κB signaling pathway, thereby exacerbating the symptoms of septic lung injury.PMID:37946128 | PMC:PMC10634032 | DOI:10.1186/s11658-023-00495-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 10, 2023 Category: Biochemistry Authors: Xinyu Ling Shiyou Wei Dandan Ling Siqi Cao Rui Chang Qiuyun Wang Zhize Yuan Source Type: research

GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
CONCLUSIONS: In summary, our study identified GCN5L1 as a new regulator of pulmonary surfactant that plays a role in the biogenesis and positioning/trafficking of surfactant-containing LBs.PMID:37936104 | PMC:PMC10631113 | DOI:10.1186/s11658-023-00506-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 7, 2023 Category: Biochemistry Authors: Wenqin Xu Xiaocui Ma Qing Wang Jingjing Ye Nengqian Wang Zhenzhen Ye Tianbing Chen Source Type: research

GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
CONCLUSIONS: In summary, our study identified GCN5L1 as a new regulator of pulmonary surfactant that plays a role in the biogenesis and positioning/trafficking of surfactant-containing LBs.PMID:37936104 | DOI:10.1186/s11658-023-00506-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 7, 2023 Category: Biochemistry Authors: Wenqin Xu Xiaocui Ma Qing Wang Jingjing Ye Nengqian Wang Zhenzhen Ye Tianbing Chen Source Type: research

Cellular senescence in skeletal disease: mechanisms and treatment
Cell Mol Biol Lett. 2023 Oct 27;28(1):88. doi: 10.1186/s11658-023-00501-5.ABSTRACTThe musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the balance of bone homeostasis is disrupted, leading to bone loss and degenerative diseases, such as osteoporosis, osteoarthritis, and intervertebral disc degeneration. Skeletal diseases have a profound impact on the motor and cognitive abilities of the elderly, thus creating a major challenge for both global health and the economy. Cellular senescence is caused by various genotoxic stressors and r...
Source: Cellular and Molecular Biology Letters - October 27, 2023 Category: Biochemistry Authors: Xu He Wei Hu Yuanshu Zhang Mimi Chen Yicheng Ding Huilin Yang Fan He Qiaoli Gu Qin Shi Source Type: research

N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2'-O methylation
CONCLUSIONS: This study identified an oncofetal lncRNA MIR4435-2HG, characterized the role of MIR4435-2HG/NOP58 in stemness maintenance and proliferation of HCC cells, and confirmed m6A as a 'driver' that reactivated MR4435-2HG expression in HCC.PMID:37891494 | PMC:PMC10612268 | DOI:10.1186/s11658-023-00493-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 27, 2023 Category: Biochemistry Authors: Yiqing Zhu Bang Xiao Meng Liu Meiting Chen Ningqi Xia Haiyan Guo Jinfeng Huang Zhiyong Liu Fang Wang Source Type: research