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Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
CONCLUSIONS: This study shows that inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction. SQSTM1 T269/S272 phosphorylation inhibits the S403 phosphorylation, boosting the aggresome formation of ubiquitinated protein and shielding cells from proteotoxic crisis.PMID:37872526 | PMC:PMC10594750 | DOI:10.1186/s11658-023-00500-6 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 23, 2023 Category: Biochemistry Authors: Chenliang Zhang YiChun Duan Chen Huang Liping Li Source Type: research

Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Cell Mol Biol Lett. 2023 Oct 20;28(1):84. doi: 10.1186/s11658-023-00499-w.NO ABSTRACTPMID:37864186 | PMC:PMC10589975 | DOI:10.1186/s11658-023-00499-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 20, 2023 Category: Biochemistry Authors: Zhitao Zhang Yanzhen Han Guangxin Sun Xiaohong Liu Xiaoyan Jia Xiangjun Yu Source Type: research

A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
CONCLUSION: The present study identified a novel ZFX/WNT3 axis that modulates the growth and IM response of CML stem/progenitor cells.PMID:37864206 | PMC:PMC10589942 | DOI:10.1186/s11658-023-00496-z (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 20, 2023 Category: Biochemistry Authors: Xiuyan Zhang Yu Wang Jinchang Lu Lun Xiao Hui Chen Quanxue Li Yuan-Yuan Li Peng Xu Changgeng Ruan Haixia Zhou Yun Zhao Source Type: research

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
Cell Mol Biol Lett. 2023 Oct 19;28(1):81. doi: 10.1186/s11658-023-00491-4.ABSTRACTEarly and prompt reperfusion therapy has markedly improved the survival rates among patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling and the subsequent onset of heart failure remain formidable clinical management challenges and represent a primary cause of disability in MI patients worldwide. Macrophages play a crucial role in immune system regulation and wield a profound influence over the inflammatory repair process following MI, thereby dictating the degree of myocardial injury and the subsequent ...
Source: Cellular and Molecular Biology Letters - October 19, 2023 Category: Biochemistry Authors: Wenjie Zuo Renhua Sun Zhenjun Ji Genshan Ma Source Type: research

Correction: Profiling the impact of the promoters on CRISPR-Cas12a system in human cells
Cell Mol Biol Lett. 2023 Oct 19;28(1):82. doi: 10.1186/s11658-023-00502-4.NO ABSTRACTPMID:37858095 | PMC:PMC10588130 | DOI:10.1186/s11658-023-00502-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 19, 2023 Category: Biochemistry Authors: Jinhe Li Qingchun Liang HuaPing Zhou Ming Zhou Hongxin Huang Source Type: research

Correction: Profiling the impact of the promoters on CRISPR-Cas12a system in human cells
Cell Mol Biol Lett. 2023 Oct 19;28(1):82. doi: 10.1186/s11658-023-00502-4.NO ABSTRACTPMID:37858095 | DOI:10.1186/s11658-023-00502-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 19, 2023 Category: Biochemistry Authors: Jinhe Li Qingchun Liang HuaPing Zhou Ming Zhou Hongxin Huang Source Type: research

MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
CONCLUSIONS: Together, we identified MCCC2 as a novel mediator between mitochondria and telomeres, and provided an additional biomarker for CRC stratification.PMID:37828426 | PMC:PMC10571261 | DOI:10.1186/s11658-023-00487-0 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Wanjun Liu Si Chen Wenqing Xie Qian Wang Qianxin Luo Minghan Huang Minyi Gu Ping Lan Daici Chen Source Type: research

Activation of BZW1 by CEBPB in macrophages promotes eIF2 α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
CONCLUSION: Transcriptional activation of BZW1 by CEBPB promoted phosphorylation of eIF2α to promote macrophage glycolysis and endoplasmic reticulum stress in the development of LN.PMID:37828427 | PMC:PMC10571419 | DOI:10.1186/s11658-023-00494-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Huimeng Qi Zhaoguo Zheng Qiang Liu Source Type: research

N < sup > 6 < /sup > -methyladenosine modification-a key player in viral infection
Cell Mol Biol Lett. 2023 Oct 12;28(1):78. doi: 10.1186/s11658-023-00490-5.ABSTRACTN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-binding proteins ("readers"). m6A modification and related enzymes could represent an optimal strategy to deepen the epigenetic mechanism. Numerous reports have suggested that aberrant modifications of m6A lead to aberrant expression of important viral genes. Here, we review the role of m6A modific...
Source: Cellular and Molecular Biology Letters - October 12, 2023 Category: Biochemistry Authors: Xiaoyue Zhang Qiu Peng Lujuan Wang Source Type: research