Cellular and Molecular Biology Letters This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer's disease
Cell Mol Biol Lett. 2023 Nov 30;28(1):98. doi: 10.1186/s11658-023-00504-2.ABSTRACTAlzheimer's disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no known medication that will stop the course of Alzheimer's disease; instead, most symptoms are treated. Clinical trial failure rates for new drugs remain high, highlighting the urgent need for improved AD modeling for improving understanding of the underlying pathophysiology of disease and improving drug development. The development of induced pluripotent stem cells (iPSCs) has made it possible to mod...
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Hany E Marei Muhammad Umar Aslam Khan Anwarul Hasan Source Type: research

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
This study provides a potentially effective anti-cancer strategy for gene therapy of prostate cancer.PMID:38017385 | PMC:PMC10685504 | DOI:10.1186/s11658-023-00508-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Yi Yang Hongbing Mei Xiaohong Han Xintao Zhang Jianli Cheng Zhongfu Zhang Han Wang Haixia Xu Source Type: research

Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Cell Mol Biol Lett. 2023 Nov 29;28(1):97. doi: 10.1186/s11658-023-00511-3.ABSTRACTArachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 gene is structurally similar to the orthologous genes of other mammals. However, mouse and human ALOX15 orthologs have different functional characteristics. Human ALOX15 converts C20 polyenoic fatty acids like arachidonic acid mainly to the n-6 hydroperoxide. In contrast, the n-9 hydroperoxide is the major o...
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Florian Reisch Dagmar Heydeck Marjann Sch äfer Michael Rothe Jiaxing Yang Sabine Stehling Gerhard P P üschel Hartmut Kuhn Source Type: research

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
This study provides a potentially effective anti-cancer strategy for gene therapy of prostate cancer.PMID:38017385 | DOI:10.1186/s11658-023-00508-y (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 29, 2023 Category: Biochemistry Authors: Yi Yang Hongbing Mei Xiaohong Han Xintao Zhang Jianli Cheng Zhongfu Zhang Han Wang Haixia Xu Source Type: research

Astaxanthin alleviates PM < sub > 2.5 < /sub > -induced cardiomyocyte injury via inhibiting ferroptosis
CONCLUSIONS: Our study suggest that ferroptosis plays a significant role in the pathogenesis of cardiomyocyte injury induced by PM2.5. AST may serve as a potential therapeutic agent for mitigating cardiomyocyte injury caused by PM2.5 through the inhibition of ferroptosis.PMID:38007415 | PMC:PMC10675963 | DOI:10.1186/s11658-023-00513-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 25, 2023 Category: Biochemistry Authors: Jingyi Ren Bowen Yin Zihao Guo Xiaoya Sun Huanting Pei Rui Wen Ziyi Wang Siqi Zhu Jinshi Zuo Yadong Zhang Yuxia Ma Source Type: research

Astaxanthin alleviates PM < sub > 2.5 < /sub > -induced cardiomyocyte injury via inhibiting ferroptosis
CONCLUSIONS: Our study suggest that ferroptosis plays a significant role in the pathogenesis of cardiomyocyte injury induced by PM2.5. AST may serve as a potential therapeutic agent for mitigating cardiomyocyte injury caused by PM2.5 through the inhibition of ferroptosis.PMID:38007415 | DOI:10.1186/s11658-023-00513-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 25, 2023 Category: Biochemistry Authors: Jingyi Ren Bowen Yin Zihao Guo Xiaoya Sun Huanting Pei Rui Wen Ziyi Wang Siqi Zhu Jinshi Zuo Yadong Zhang Yuxia Ma Source Type: research

Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Cell Mol Biol Lett. 2023 Nov 24;28(1):94. doi: 10.1186/s11658-023-00512-2.NO ABSTRACTPMID:38001445 | PMC:PMC10668409 | DOI:10.1186/s11658-023-00512-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 24, 2023 Category: Biochemistry Authors: Ma ša Mavri Sanja Gli šić Milan Sen ćanski Milka Vrecl Mette M Rosenkilde Katja Spiess Valentina Kubale Source Type: research

Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Cell Mol Biol Lett. 2023 Nov 24;28(1):94. doi: 10.1186/s11658-023-00512-2.NO ABSTRACTPMID:38001445 | DOI:10.1186/s11658-023-00512-2 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 24, 2023 Category: Biochemistry Authors: Ma ša Mavri Sanja Gli šić Milan Sen ćanski Milka Vrecl Mette M Rosenkilde Katja Spiess Valentina Kubale Source Type: research

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
CONCLUSION: Overall, manipulating periostin expression may function as a promising strategy in the treatment of DCM.PMID:37993768 | PMC:PMC10666354 | DOI:10.1186/s11658-023-00510-4 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 22, 2023 Category: Biochemistry Authors: Qing-Bo Lu Xiao Fu Yao Liu Zi-Chao Wang Shi-Yi Liu Yu-Chao Li Hai-Jian Sun Source Type: research

Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
CONCLUSIONS: The aforementioned results indicate that exosomal miR-155-5p drives widespread macrophage inflammation and M1 polarization in hvKp-induced ALI through the MSK1/p38-MAPK Axis.PMID:37953267 | PMC:PMC10641976 | DOI:10.1186/s11658-023-00505-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - November 12, 2023 Category: Biochemistry Authors: Yihan Xu Chunying Zhang Danni Cai Rongping Zhu Yingping Cao Source Type: research