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S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research
CRISPR applications in cancer diagnosis and treatment
Cell Mol Biol Lett. 2023 Sep 6;28(1):73. doi: 10.1186/s11658-023-00483-4.ABSTRACTCancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic options beyond conventional treatments. In this regard, clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as highly promising tools for clinical gene editing applications. The CRISPR family encompasses diverse CRISPR-associated (Cas) proteins that possess the ability to recognize specific target sequences. The initial CRISPR system consisted of the Cas9 protein and a single-guide RNA, w...
Source: Cellular and Molecular Biology Letters - September 6, 2023 Category: Biochemistry Authors: Mingxia Wang Menghui Chen Xia Wu Xinbo Huang Bo Yu Source Type: research