Cellular and Molecular Biology Letters 
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CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | PMC:PMC10560431 | DOI:10.1186/s11658-023-00492-3 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | PMC:PMC10560431 | DOI:10.1186/s11658-023-00492-3 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | PMC:PMC10560431 | DOI:10.1186/s11658-023-00492-3 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | PMC:PMC10560431 | DOI:10.1186/s11658-023-00492-3 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | DOI:10.1186/s11658-023-00492-3 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.ABSTRACTDuring aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess d...
Source: Cellular and Molecular Biology Letters - September 30, 2023 Category: Biochemistry Authors: Jana Riegger Astrid Schoppa Leonie Ruths Melanie Haffner-Luntzer Anita Ignatius Source Type: research
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.ABSTRACTDuring aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess d...
Source: Cellular and Molecular Biology Letters - September 30, 2023 Category: Biochemistry Authors: Jana Riegger Astrid Schoppa Leonie Ruths Melanie Haffner-Luntzer Anita Ignatius Source Type: research
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.ABSTRACTDuring aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess d...
Source: Cellular and Molecular Biology Letters - September 30, 2023 Category: Biochemistry Authors: Jana Riegger Astrid Schoppa Leonie Ruths Melanie Haffner-Luntzer Anita Ignatius Source Type: research
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.ABSTRACTDuring aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess d...
Source: Cellular and Molecular Biology Letters - September 30, 2023 Category: Biochemistry Authors: Jana Riegger Astrid Schoppa Leonie Ruths Melanie Haffner-Luntzer Anita Ignatius Source Type: research
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Cell Mol Biol Lett. 2023 Sep 30;28(1):76. doi: 10.1186/s11658-023-00489-y.ABSTRACTDuring aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess d...
Source: Cellular and Molecular Biology Letters - September 30, 2023 Category: Biochemistry Authors: Jana Riegger Astrid Schoppa Leonie Ruths Melanie Haffner-Luntzer Anita Ignatius Source Type: research
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Cell Mol Biol Lett. 2023 Sep 28;28(1):75. doi: 10.1186/s11658-023-00485-2.ABSTRACTOsteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and disability worldwide. Despite current treatments, the overall treatment outcome is unsatisfactory. Thus, patients with severe OA often require joint replacement surgery. In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for preclinical and clinical palliation of OA. MSC-derived exosomes (MSC-Exos) carrying bioactive molecules of the parental cells, includ...
Source: Cellular and Molecular Biology Letters - September 28, 2023 Category: Biochemistry Authors: Zehao Zhang Sheng Zhao Zhaofeng Sun Chuanxing Zhai Jiang Xia Caining Wen Yuge Zhang Yuanmin Zhang Source Type: research
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Cell Mol Biol Lett. 2023 Sep 28;28(1):75. doi: 10.1186/s11658-023-00485-2.ABSTRACTOsteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and disability worldwide. Despite current treatments, the overall treatment outcome is unsatisfactory. Thus, patients with severe OA often require joint replacement surgery. In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for preclinical and clinical palliation of OA. MSC-derived exosomes (MSC-Exos) carrying bioactive molecules of the parental cells, includ...
Source: Cellular and Molecular Biology Letters - September 28, 2023 Category: Biochemistry Authors: Zehao Zhang Sheng Zhao Zhaofeng Sun Chuanxing Zhai Jiang Xia Caining Wen Yuge Zhang Yuanmin Zhang Source Type: research
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Cell Mol Biol Lett. 2023 Sep 28;28(1):75. doi: 10.1186/s11658-023-00485-2.ABSTRACTOsteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and disability worldwide. Despite current treatments, the overall treatment outcome is unsatisfactory. Thus, patients with severe OA often require joint replacement surgery. In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for preclinical and clinical palliation of OA. MSC-derived exosomes (MSC-Exos) carrying bioactive molecules of the parental cells, includ...
Source: Cellular and Molecular Biology Letters - September 28, 2023 Category: Biochemistry Authors: Zehao Zhang Sheng Zhao Zhaofeng Sun Chuanxing Zhai Jiang Xia Caining Wen Yuge Zhang Yuanmin Zhang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
