lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization

CONCLUSION: Our results unveil a lnc-Helf/PTBP1/PIK3R5/AKT feedforward, amplifying signaling that exacerbates the process of hepatic inflammation and fibrosis, thus providing a possible therapeutic strategy for hepatic fibrosis.PMID:37805473 | DOI:10.1186/s11658-023-00492-3

Source: Cellular and Molecular Biology Letters - October 7, 2023 Category: Biochemistry Authors: Xiaohui Han Beichen Guo Sicong Zhao Yehua Li Jing Zhu Yifan He Jiajun Wang Qingbin Yao Shuai Shao Lina Zheng Zhemin Shi Tao Han Wei Hong Kun Zhang Source Type: research